Protein Alignment SMC2 and Smc6

DIOPT Version :9

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_001101484.1
• Gene: Smc6 / 313961
• RGDID: 1311214
• Length: 1097
• Species: Rattus norvegicus
• Alignment Length: 1258
• Identity: 269/1258 - (21%)
• Similarity: 476/1258 - (37%)
• Gaps: 346/1258 - (27%)

  Fly    23 FDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVYKNGQAGITKATVTIVFDNTN 87
            |......:.|.||||||.:|.::...||...:...|.|:|:..|    :||...|.::|...|
  Rat    73 FGSNVNFVVGNNGSGKSAVLTALIVGLGGKAVATNRGSSLKGFV----KAGQNSADISITLRN-- 131

  Fly    88 PAQCPQGYEKCR------EISVTRQVVVGGKNKFLI---NGKLVQNKK-----VQDFFCSIQLNV 138
                 :|.:..|      .|.|.:.:.|.|...:.:   .|.:|..:|     :.|.|   .:.|
  Rat   132 -----RGDDAFRANVYGDSIVVQQHISVDGSRSYKLKSEKGTVVSTRKEELIAILDHF---NIQV 188

  Fly   139 NNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKE--TKVRETKVLLDE 201
            :||..::.|...:|.|..|.:           ..:||....||: |.:.||  :.:.|||....|
  Rat   189 DNPVSVLTQEMSKQFLQSKNE-----------GDKYKFFMKATQ-LEQMKEDYSYIMETKERTKE 241

  Fly   202 EVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIEDRIANCKAT 266
            ::       .|......|.::.|.:                                     |..
  Rat   242 QI-------NQGEERLTELKRQCLE-------------------------------------KEE 262

  Fly   267 HAKNLAEVESIENSVKEMQQQIDAEMGGSIKN-LETQLSAKRALEATATGSLKAAQGTIQQDEKK 330
            ..:|:|.:.:::.:::.::.    ||..::.| :|.||:|.|
  Rat   263 RFQNIAGLSTMKTNLEYLKH----EMAWAVVNEIEKQLNAIR----------------------- 300

  Fly   331 IRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLSTNENG-E 394
                 .||:..|...||.:..|     |.:.::..||  .|.|:|.|.|||.:|:  .||... |
  Rat   301 -----DNIKIGEERAAKLDRKM-----EEQQVRLNDA--EKKYKDIQDKLEKISE--ETNARAPE 351

  Fly   395 ASTLQEQLIVAKEQFSEAQTTIKTSEIE---LRHTRGVLKQREGETQTNDAAYVKDKKLHDQ--- 453
            ...|:..:|.....|::|:.....|..|   |:.....|.:|..|.:.:....::.::|..|
  Rat   352 CMALKTDVIARTRAFNDAEVLYNRSLNEYKALKKDGEQLCKRIEELKKSTDQSLEPERLERQKRI 416

  Fly   454 --LVVEIKNLERQLQSLDYEGGHFEKL--KQRRNDLHMRKRDL---------KRELDRCNASRYD 505
              |..::|.|:.|..:::.|...||:.  |.::..:.:::.|:         :|:|.....|:.|
  Rat   417 CWLKEKVKALQDQENTVNQEVEQFEQAIEKDKQEHVRIKREDVEVRHTLSYNQRQLKELKDSKTD 481

  Fly   506 -LQYQDP---------EPNFDRR----KVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYV----T 552
             |:...|         :..:.||    |..|.:|....::|.:.::|:.....|.|.:|.    .
  Rat   482 RLKRFGPHVPALLEAIDDAYRRRQFTHKPIGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHA 546

  Fly   553 DDDVTS---KKILQRGNLQRRVTLIPINKIQSGSLNRNVVEYAQNKV------------------ 596
            |:.|..   ||....|..:.::                :|...:|:|
  Rat   547 DERVLQSLMKKFYPPGTSRPQI----------------IVSEFRNEVYDVRLRAAYHPEFPTVLT 595

  Fly   597 --GAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQI--SYDPRINCR-SVTLEGDVVD 656
              ..:|...|.||||. |..|.|        |:.|:..||:.:  |..|..||| :.|.:||.|.
  Rat   596 ALEIDNAVVANSLIDM-RSIETV--------LLIKNNSVARAVMQSQKPPKNCREAFTADGDQVF 651

  Fly   657 PHGTVSG-GAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQALAFNKMKENLDLR 720
            .....|. ...||..:               |::||||:.:|.:|.         ||....::|
  Rat   652 AGRYYSSESTRPKFLS---------------RDVDSEISDLETEIE---------NKKGHIMNL- 691

  Fly   721 QHELTMCENRLA--QTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKLADAKG 783
            ||.|:..|..:.  :...::.|...:|::.:::   :.|.:.||.:...:.:.||| |.|.|
  Rat   692 QHRLSALEKDIKRNEELLKRCQLHYKEIKMKIR---KNISEIRELENIEEHQSVDI-ATLED--- 749

  Fly   784 YRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNLEKF 848
                  .|..|:||:  |..||:....|:..:..:||::|......:|:....|..|:.|.|:
  Rat   750 ------EAEENKIKM--QMVEKNMEQQKENMENLKTLKIEAENKYDTIKLKINQLSELADPLK-- 804

  Fly   849 KAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKEKMLKENQEIELEVKKKEN 913
                |.|.:..|...|:        |..|....|:.||..:.|.||.:        ||::|:||
  Rat   805 ----DELNLADSEVDSQ--------KRGKQHYEDKQKEHMDTLNKKRR--------ELDMKEKE- 848

  Fly   914 EQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKMQEKK-DKM 977
            .|:|:|...:...:|:|.                                 .|.|.:.:|: :::
  Rat   849 LQEKMSQARQICPERIEV---------------------------------KKSASILDKEINRL 880

  Fly   978 ERTLNMNAIMVLDREEENFKETERRRNIVAMD-KEKIKKIIVKMDEEEQDQLNKAATE----VNT 1037
            .:.:........||||...:..|.|...:.:| |.:..:..:|:.||......|...:    :..
  Rat   881 RQKIQAEHASHGDREEIMKQYQEARETYLDLDSKVRTLRRFIKLLEEIMTHRYKTYQQFRRCLTL 945

  Fly  1038 NFSGIFSSLLPGAE--AKLNPVHTNGCLT-----GLEIKVGFNGIWKESLGELSGGQKSLVALSL 1095
            .....|.:||....  .|:|..|.|..|:     |...|..||     .:..||||::|...:..
  Rat   946 RCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQPGEGNKASFN-----DMRALSGGERSFSTVCF 1005

  Fly  1096 VLAMLKFSPAPLYILDEVDAALDMSHTQNIGSML-----KQHFTNSQFLIVSLKDGLFNHANVLF 1155
            :|::...:.:|...|||.|..:||.:.:....|:     .|.|  .||::::.:......::.|.
  Rat  1006 ILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDMILKMADSQRF--RQFILLTPQSMSSLPSSKLI 1068

  Fly  1156 RTLF----EEGVSTIT-RQVSRQ 1173
            |.|.    |.|.:|:. |.|:::
  Rat  1069 RILRMSDPERGQTTLPFRPVTQE 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	267/1251 (21%)
		ABC_SMC2_euk	1..>170	CDD:213240	38/160 (24%)
		SMC_hinge	520..637	CDD:214944	28/143 (20%)
		V_Alix_like	690..933	CDD:187408	62/244 (25%)
		P-loop_NTPase	<1073..1167	CDD:304359	25/102 (25%)
Smc6	NP_001101484.1	Smc	54..1075	CDD:224117	264/1240 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810