Protein Alignment SMC2 and Smc1b

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_001123970.1
• Gene: Smc1b / 300121
• RGDID: 1308791
• Length: 1247
• Species: Rattus norvegicus
• Alignment Length: 1308
• Identity: 280/1308 - (21%)
• Similarity: 562/1308 - (42%)
• Gaps: 270/1308 - (20%)

  Fly     2 YVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLV 66
            :::.|:::.|||:..|..|..| ..||.|.|.|||||||::|::.||:| ....|:|...:|:|:
  Rat     3 HLELLLVENFKSWRGRQVIGPF-KRFTCIIGPNGSGKSNVMDALSFVMG-EKTTNLRVKNIQELI 65

  Fly    67 Y--KNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQD 129
            :  ..|:...:.|:|||::...:      |.||    :.|| ::.||.::|....|.|.......
  Rat    66 HGAHIGKPVSSSASVTIIYVEDS------GEEK----TFTR-IIRGGCSEFHFGDKPVSRSVYVA 119

  Fly   130 FFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKV-- 192
            ...:|.:.|...|.|:.||.::.:...||||.....||.:.:.::..:.:|.|..::|.|...
  Rat   120 QLENIGIIVKAQNCLVFQGTVESISMKKPKERTQFFEEISTSGEFIGEYEAKKKKLQKAEEDAQF 184

  Fly   193 ---RETKVLLDEEVLPKLVKLRQERSAYQEYQKICRDID------FLIRIHISAKYLKQCET-LK 247
               |:..|..:.    |..|:.:|.:  :.||.:..::.      .|.:::.:.:.:....| |:
  Rat   185 HFNRKKNVAAER----KHAKIEKEEA--EHYQSLLEELKTNKIQLMLFQLYYNEEKINVLNTELE 243

  Fly   248 TVEANEHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEAT 312
            .::.|...::|.:     :|.:|:.:.:..:..:...|.|..|:   .:|::|..|:.||
  Rat   244 HMDRNLSVVKDTL-----SHHENIIKAKKKDYGMLTRQLQQTAK---ELKSVEAVLNQKR----- 295

  Fly   313 ATGSLKAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQ 377
             ...:||.:.| ....||:.::.|.|.|:|:..||:|..:..:..|...|       .:|:...:
  Rat   296 -PQYIKAKENT-SHHLKKLDLSKKLITDNEKQCAKQEDGIRALVAELVDL-------DRAWRSFE 351

  Fly   378 KKLE--AVSQG----LSTNENGEASTLQEQLI----VAKEQFSEAQTTIKTSEIEL-----RH-- 425
            |::|  .:.:|    |..::......|:||:.    :..:|..:.|...|..:..|     ||
  Rat   352 KQMEEKILHKGRDIELENSQLDRYKELKEQVRRRVGIMTQQLEKLQWEQKAEKERLAFERRRHGD 416

  Fly   426 TRGVLKQREGETQTND------AAYVK-------DKKLHDQ-LVVEIKNLERQLQSLDYEGGHFE 476
            |:|.|||.:.:.:.:.      ..|.|       |||..:: |:.||.|.:.::..::      |
  Rat   417 TQGNLKQIKEQIEEHKKRIEKLEEYTKTCMDCLEDKKQQEEALIKEIDNTKSRMSEVN------E 475

  Fly   477 KLKQRRNDL-------HMRKRDLKRE--LDRCNASRYDLQYQDPEPNFDR---------RKVRGL 523
            :|...||:|       |..||..||.  |:.       |:...|:..|.|         :|.:..
  Rat   476 ELSLIRNELQNAGIDNHEGKRQRKRAEVLEH-------LKRLYPDSVFGRLLDLCHPIHKKYQLA 533

  Fly   524 VGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQRR--VTLIPINKIQSGSLNR 586
            |.|||               |..:.:.|...:..:|..::....:|.  .|.:.::.:....:|.
  Rat   534 VTKLF---------------GRYMVAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINE 583

  Fly   587 NVVEYAQNKVGAENVQWAMSLIDYDRYYEP----VMKFCFGGTLICKDLIVAKQISYDPRINCRS 647
            .:.|          ::....:||..:...|    |::|..|..|:|:.:..|:.|::......::
  Rat   584 RLRE----------IKGCKMMIDVIKTQFPQLKKVIQFVCGNGLVCETVEEARHIAFGGPERRKA 638

  Fly   648 VTLEGDVVDPHGTVSGGAAPKGANVL----EELHAIK----QIEKEYREI------DSEIAQVEK 698
            |.|:|.:....|.:|||::......|    :|||:::    |:.:|.:|:      ::::.|::.
  Rat   639 VALDGTLFLKSGVISGGSSDLKHKALCWDEKELHSLRDKRNQLVQELKELMKTLRKETDLKQIQA 703

  Fly   699 QIASIENQALAFNKMKENLDLRQHELTMCENRLAQTTFQ---QNQAEIEEMRERVKTLEQQIIDS 760
            .:.....:          |...|:||.|.:.:...|.::   |.|:|:..:..:...|.:.|...
  Rat   704 LVQGTNTR----------LKYSQNELEMIKKKHLATFYREQSQLQSELLNIDSQCTMLSEGINKQ 758

  Fly   761 REKQKTSQAKIVDIEAKL---------------ADAKGYRERELNAATNEIKVTKQRA------E 804
            ::|.:..|.||..:|..:               .:.|..::::.| ....::..||:.      |
  Rat   759 QQKIEEFQDKIDKVEDDIFQDFCEEIGVENIREFENKHVKQQQEN-DQKRLEFEKQKTRLNIQLE 822

  Fly   805 KSRANWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTEL 869
            .||...||:..:.:||:..|.:.::.|:..||..:|.:..:|:...:.:.:|...::.:|.:.::
  Rat   823 YSRNQLKKKLNKIDTLKTTIQKGREDIDNLKKTEEECLKIVEELMVKQEQVKEVLATQSSNIEKI 887

  Fly   870 EQAIKEQKDKLRDQNKE---MRNQLV------KKEKMLKEN-------QEIE-----------LE 907
            ...|:|::.|....::|   ::.::|      :::::.|.|       |:|:           :|
  Rat   888 HIQIEEERKKFLAVDREVGKLQKEVVIIQGSLEQKQLEKHNLLLDCKVQDIDISLMLGSLEDIIE 952

  Fly   908 VKKKENEQKKISSD--AKEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKM 970
            |:..|.|..:.::|  .|||..:::....:..|                .:.:...|....|..:
  Rat   953 VELTETESTQATADIYEKEASIQIDYSPLREDW----------------KALQSDKEVEAHLTLL 1001

  Fly   971 QEKKDKMERTL------------NMNAIMVLDREEEN---FKETERRRNIVAMDKEKIKKIIVKM 1020
            .::....|.||            |:.|  |.|:.:|:   |:.:.:...|...:.|::|:
  Rat  1002 LQQVASQENTLLKTAAPNLRAQENLKA--VRDKFQESADAFEASRKEARICRQEFEQVKR----- 1059

  Fly  1021 DEEEQDQLNKAATEVNTNFSGIFSSLL--PGAEAKLNPVH-TNGCLTGLEIKVGFNGIWKESLGE 1082
              ...|..::....::.:...|:..|.  ..|:|.|:|.: ....|.|:.......|.....:..
  Rat  1060 --RRYDAFSQCFEHISVSIDQIYKKLCRNNSAQAFLSPENPEEPYLDGISYNCVAPGKRFMPMDN 1122

  Fly  1083 LSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNS-QFLIVSLKDG 1146
            ||||:|.:.||:|:.|:..|.|||.::|||||||||.::...:...:|:..... |.:|:|||:.
  Rat  1123 LSGGEKCVAALALLFAVHSFRPAPFFVLDEVDAALDNTNIGKVSGYIKEQSQEQFQMIIISLKEE 1187

  Fly  1147 LFNHANVL 1154
            .::.|:.|
  Rat  1188 FYSRADAL 1195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	280/1308 (21%)
Smc1b	NP_001123970.1	SMC_N	3..1203	CDD:481474	280/1308 (21%)