Protein Alignment SMC2 and Smc5

DIOPT Version :9

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_006231245.1
• Gene: Smc5 / 293967
• RGDID: 1307492
• Length: 1102
• Species: Rattus norvegicus
• Alignment Length: 1211
• Identity: 248/1211 - (20%)
• Similarity: 477/1211 - (39%)
• Gaps: 277/1211 - (22%)

  Fly     3 VKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVY 67
            :.::.::.|.:|.......|  |....|.|.||:|||:|:.:||  ||::........|  |.|.
  Rat    53 IVRIAMENFLTYDICEVSPG--PHLNMIIGANGTGKSSIVCAIC--LGLAGKPAFMGRA--DKVG 111

  Fly    68 KNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQV-VVGGKNKFLINGKLVQNKKVQDFF 131
            ...:.|.:|..|.|....|:           ..:.:||:: |:..::.:.||.|.|..|.|::..
  Rat   112 FFVKRGCSKGLVEIELFRTS-----------GNLIITREIDVIKNQSFWFINKKPVTQKIVEEQV 165

  Fly   132 CSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRETK 196
            .::.:.|.|....:.|.|:.:...:...|:|...|::.|..:........|...||:  |..||.
  Rat   166 AALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHRYHCELKNFREKE--KQLETS 228

  Fly   197 VLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIEDRIA 261
            .....|.|.|::: |.||  |::      |::   |.:...::|   :.::.:||....:|
  Rat   229 CKEKTEYLDKMIQ-RNER--YKQ------DVE---RFYERKRHL---DLIEMLEAKRPWVE---- 274

  Fly   262 NCKATHAKNLAE----VESIENSVKEMQQQI---DAEMGGSIKNLETQLSAKRALEATATGSLKA 319
                  .:|:.:    |:.:.:.|||..:::   ...|...|:.:|.|   :|.||.
  Rat   275 ------YENVRQEYEGVKLVRDRVKEEVRKLKEGQIPMTRRIEEIERQ---RRTLEV-------- 322

  Fly   320 AQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARD-SKAYEDAQKKLEAV 383
               .|::....|:.||:..:..:..:.:|:..:.::| :..::|:.:.:| .|...:.:|.:|.:
  Rat   323 ---RIKEKATDIKEASQKCKQRQDLIERKDRHIKELQ-QALTVKQNEEQDRQKRISNTRKMIEDL 383

  Fly   384 SQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDK 448
            ...|.|.||.|  .||.|:..........|......|.|:     :.||||.|.
  Rat   384 QNELRTAENCE--NLQPQIDAITNDLRRVQEEKALCEGEI-----IDKQREKEM----------- 430

  Fly   449 KLHDQLVVEIKNLERQLQSLDYEGGHFEKLKQRRND-LHMRKRDLKRELDRCNASRYD--LQYQD 510
                        ||:|.:|:......|:.|..::.| |..|.||           .||  |..::
  Rat   431 ------------LEKQKRSVSDHITRFDNLMNQKEDKLRQRYRD-----------TYDAVLWLRN 472

  Fly   511 PEPNFDRRKVRGLVGKLFQVKDMQNSMALV-QTAGGSLYSYVTDDDVTSKKILQ--RGNLQRRVT 572
            ....|.:|....:: ....:||.:|:..:. ..:...|.::|.:.....:..|:  |.|.:.||.
  Rat   473 NRDRFKQRVCEPIM-LTINMKDNKNAKYVENHISSNDLRAFVFESQEDMEIFLREVRDNKKLRVN 536

  Fly   573 LIPINKIQ------SGSLNR----NVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLI 627
            .:...||.      |.|||.    ....|.:....|.:...:.....|..:..||      ||..
  Rat   537 AVIAPKISYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPV------GTER 595

  Fly   628 CKDLIVAKQISYDPRINCRSVTLEGDVV-----DPHGTVSGGAAPKGANVLEELHAIKQIEKEYR 687
            .::.|  :::..:.|:. :..|.|...|     ..:..:|...:.|.|..|.....::|    .|
  Rat   596 TRERI--ERVIQETRLK-QIYTAEEKYVLKTSFYSNKVISSNTSLKVAQFLTVTVDLEQ----RR 653

  Fly   688 EIDSEIAQVEKQIASIENQALAFNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKT 752
            .::.::.::.:::.::::..:|......:|:|:.:||.:            .:.|:.|.:.:.:.
  Rat   654 HLEEQLKEINRKLEAVDSGLVALRDTNRHLELKDNELRL------------KKKELLERKTKKRQ 706

  Fly   753 LEQQIIDSREKQKTSQAKIVDIEAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEF 817
            |||:|          .:|:..|.....|.....|.|..|:|...::..|:|:.
  Rat   707 LEQKI----------SSKLASIRLMEQDTCNLEEEERKASTKIKEINVQKAKL------------ 749

  Fly   818 ETLQLEITELQKSIETAKKQHQEMIDNL--------EKFKAELDALKVNSSSAASEVTELEQAIK 874
                  :|||...::.....|.:.:|.:        ||.|.|.|.:   :||:...||| :|.|:
  Rat   750 ------VTELTGLVKICTSLHIQKVDLILQNTTVISEKNKLEADYM---ASSSQLRVTE-QQFIE 804

  Fly   875 EQKDKLRDQNKEMRNQLVKKEKMLKENQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWI 939
                  .|.|   |.:|::|.|          |:.|:..:...:|:|....::    .:.:.|.|
  Rat   805 ------LDDN---RQRLLQKCK----------ELMKRARQVCNLSADQAVPQE----FQTQVPTI 846

  Fly   940 PEEKNCFGMKNTRYDYSKEDP---HEAGNKL----AKMQEKKDKMERTLNMNAIMVLDREEENFK 997
            |.            .:|...|   .:..|.|    |.:.|::.:......:|..:|   ||...:
  Rat   847 PN------------GHSSSPPMAFQDLPNTLDEIDALLTEERSRASCFTGLNPSVV---EEYTKR 896

  Fly   998 ETERRRNIVAMDKEKIKKIIVKMDEEEQ----------DQLNKAATEVNTNFSGIFSSLLPGAEA 1052
            |.|     :....|::|...|::||..:          :.|.:...::|..||..|||:....|.
  Rat   897 EIE-----IQQLTEELKGKKVELDEYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEV 956

  Fly  1053 KLNPVHTNG----CLTGLEIKVGFNGIWKESLGEL-----SGGQKSLVALSLVLAMLKFSPAPLY 1108
            .|   ||..    ...|:.|:|.|..  ...|.||     |||::|:..:..::|:.:.:..|..
  Rat   957 DL---HTENEEDYDKYGIRIRVKFRS--STQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFR 1016

  Fly  1109 ILDEVDAALDMSHTQNIGSML-----KQHFTNSQFLIVSLK 1144
            ::||::..:|..:.:.:..|:     |::  .||:..::.|
  Rat  1017 VVDEINQGMDPINERRVFEMVVNTACKEN--TSQYFFITPK 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	248/1211 (20%)
		ABC_SMC2_euk	1..>170	CDD:213240	40/167 (24%)
		SMC_hinge	520..637	CDD:214944	24/129 (19%)
		V_Alix_like	690..933	CDD:187408	47/250 (19%)
		P-loop_NTPase	<1073..1167	CDD:304359	17/82 (21%)
Smc5	XP_006231245.1	ABC_SMC5_euk	51..>196	CDD:213244	38/159 (24%)
		Smc	53..1055	CDD:224117	247/1209 (20%)
		ABC_SMC5_euk	<975..1077	CDD:213244	19/85 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810