Protein Alignment SMC2 and cut14

DIOPT Version :9

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_596180.1
• Gene: cut14 / 2541319
• PomBaseID: SPBP4H10.06c
• Length: 1172
• Species: Schizosaccharomyces pombe
• Alignment Length: 1217
• Identity: 427/1217 - (35%)
• Similarity: 685/1217 - (56%)
• Gaps: 99/1217 - (8%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            |.:::|::||||||..||.|..:|.:|.|||||||||||||||:|||||||:|:..|||..||||
pombe     1 MKIEELIIDGFKSYAVRTVISNWDDQFNAITGLNGSGKSNILDAICFVLGITNMSTVRAQNLQDL 65

  Fly    66 VYKNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDF 130
            :||.||||||:|:|||||:|.:||..|.|:|...::|||||:::||.:|:||||.....:.||:.
pombe    66 IYKRGQAGITRASVTIVFNNRDPASSPIGFENHPQVSVTRQIIMGGTSKYLINGHRALQQNVQNL 130

  Fly   131 FCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRET 195
            |.|:|||:||||||||||:|.:|||||..|:|||:|||:||..::.:::.....:::||.||.|.
pombe   131 FQSVQLNINNPNFLIMQGRITKVLNMKATEILSMIEEASGTRMFEERKEKAFRTMQRKEAKVEEI 195

  Fly   196 KVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLK---QCETLKTVEANEHKIE 257
            ..||.||:.|:|.|||.|:..:.|||.|..|::.|..:..:..|.|   :.|.| ||:|::.  .
pombe   196 NTLLREEIEPRLTKLRTEKKTFLEYQHIYNDLERLSHLCTAYDYYKLSLKVEEL-TVQASQK--H 257

  Fly   258 DRIANCKATHAKNLAEVESIENSVKEMQQQ------------IDAEMGGSIKNLETQLSAKRALE 310
            ..||..:::...:..||..::..:|:::.:            :|:::....:|: |::|....|:
pombe   258 SHIAEMESSLQTSKQEVLILKEKIKKIEDERMRQMSVSSDRTLDSQLQTVNENI-TRISTSIELK 321

  Fly   311 ATATGSLKAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYED 375
            .||   |:...|.:||    ||..:|.:   |..|..|...:.:|...:|..|:.....||.::.
pombe   322 NTA---LEEEHGDLQQ----IRGKAKEL---ETLLRGKRKRLDEVLSVYEKRKDEHQSISKDFKS 376

  Fly   376 AQKKLEAVSQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTN 440
            .::.:.:::.||||.| |..:....:|..|::..::.:...:|:.::|   .|:.||
pombe   377 QEELISSLTTGLSTTE-GHETGYSRKLHEARDTLNDFKAEKETNRLKL---EGLNKQ-------- 429

  Fly   441 DAAYVKDKKLH-----DQLVVEIKNLERQLQSL---------DYEGGHF--EKLKQRRNDLHMRK 489
             .:..|.||..     |||..||..|:..::.|         |..|...  :||||...|    :
pombe   430 -ISLTKPKKAEATKRCDQLNREIDILQNHVEKLKMSLKNTNSDITGEDVLQQKLKQLAKD----R 489

  Fly   490 RDLKRELD--RCNASRYDLQYQDPEPNFDRRKVRGLVGKLFQV--KDMQNSMALVQTAGGSLYSY 550
            .:|..|||  :...:..:..|.||.|||||.||:|||.:|..:  ::.....||..||||.||:.
pombe   490 GNLLNELDALKSKLAYMEFTYTDPTPNFDRSKVKGLVAQLLTLNEENYDKQTALEITAGGRLYNL 554

  Fly   551 VTDDDVTSKKILQRGNLQRRVTLIPINKIQSGSLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYE 615
            :.:.:....::||:|||:||||:||:|||.|...:...|. |..|:.....|.|:.||.||....
pombe   555 IVETEKIGAQLLQKGNLKRRVTIIPLNKITSFVASAERVG-AAKKISNNKAQLALELIGYDDELL 618

  Fly   616 PVMKFCFGGTLICKDLIVAKQISYDPRINCRSVTLEGDVVDPHGTVSGGAAPKGANVLEELHAIK 680
            |.|::.||.||:|.....||::::.|.:..:||||:|||.||.||::||:..|.|..|.::..:.
pombe   619 PAMQYVFGSTLVCDTPESAKKVTFHPSVKLKSVTLDGDVYDPSGTLTGGSVNKSAGPLLQIQKLN 683

  Fly   681 QIEKEYREIDSEIAQVEKQIASIENQALAFNKMKENLDLRQHELT-MCENRLAQTTF------QQ 738
            .::.:.:.:.||..::|.|:..::.|...|:::::.:.|:||||| :.|.|...::|      ||
pombe   684 SLQLKLQVVTSEYEKLETQLKDLKTQNANFHRLEQEIQLKQHELTLLIEQRETDSSFRLLSDYQQ 748

  Fly   739 NQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKLADAKGYRERELNAATNEIKVTKQRA 803
            .:.:::::::|:..|::.|:.|      .|| |..||..:.:.|..:..::.....|....|.:.
pombe   749 YKDDVKDLKQRLPELDRLILQS------DQA-IKKIERDMQEWKHNKGSKMAELEKEFNQYKHKL 806

  Fly   804 EKSRANWKKREQEFETLQLEITELQKSIETAKKQHQ------EMIDNLEKFK-AELDALKVNSSS 861
            ::.....:|.|.::..::||..:|:..::    .||      |...:|.|.: |||:...||...
pombe   807 DEFTPILEKSENDYNGVKLECEQLEGELQ----NHQQSLVQGESTTSLIKTEIAELELSLVNEEH 867

  Fly   862 AASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKEKMLKENQEIELEVKKKENEQKKISSDAKEAK 926
            ...::|||   |:.:..|....|||:.:.....:....|....||.::|..:|..::..:...|.
pombe   868 NRKKLTEL---IEIESAKFSGLNKEIDSLSTSMKTFESEINNGELTIQKLNHEFDRLEREKSVAI 929

  Fly   927 KRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVLDR 991
            ..:..||.:..||..:|..||.:.|.:|:..::..:...:|..::.:...|.:.:|...:.::|.
pombe   930 TAINHLEKENDWIDGQKQHFGKQGTIFDFHSQNMRQCREQLHNLKPRFASMRKAINPKVMDMIDG 994

  Fly   992 EEENFKETERRRNI--VAMDKEKIKKIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKL 1054
            .|:  ||.:.|..|  :..||:||:..:..:|..::..|.|...|||::|..||..||||..|:|
pombe   995 VEK--KEAKLRSMIKTIHRDKKKIQDTVKSIDRFKRSALEKTWREVNSSFGEIFDELLPGNSAEL 1057

  Fly  1055 NPVHTNGCLTGLEIKVGFNGIWKESLGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDM 1119
            .|........||||.|....|||:||.||||||:|||||:|::::||:.|||:|||||:|||||:
pombe  1058 QPPENKEFTDGLEIHVKIGSIWKDSLAELSGGQRSLVALALIMSLLKYKPAPMYILDEIDAALDL 1122

  Fly  1120 SHTQNIGSMLKQHFTNSQFLIVSLKDGLFNHANVLFRTLFEEGVSTI 1166
            |||||||.::|..|..|||:|||||:|:|.:||.||...|.:|.|.:
pombe  1123 SHTQNIGRLIKTKFKGSQFIIVSLKEGMFTNANRLFHVRFMDGSSVV 1169

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	427/1217 (35%)
		ABC_SMC2_euk	1..>170	CDD:213240	105/168 (63%)
		SMC_hinge	520..637	CDD:214944	46/118 (39%)
		V_Alix_like	690..933	CDD:187408	58/256 (23%)
		P-loop_NTPase	<1073..1167	CDD:304359	58/94 (62%)
cut14	NP_596180.1	Smc	1..1169	CDD:224117	427/1215 (35%)
		ABC_SMC2_euk	1..>172	CDD:213240	106/170 (62%)
		SMC_hinge	522..640	CDD:214944	46/118 (39%)
		P-loop_NTPase	<1076..1170	CDD:304359	58/94 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	667	1.000	Domainoid score	I17
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4705
Inparanoid	1	1.050	674	1.000	Inparanoid score	I114
OMA	1	1.010	-	-		QHG54206
OrthoFinder	1	1.000	-	-		FOG0003760
OrthoInspector	1	1.000	-	-		oto101099
orthoMCL	1	0.900	-	-		OOG6_101492
Panther	1	1.100	-	-	LDO	PTHR43941
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1352
SonicParanoid	1	1.000	-	-		X3124
TreeFam	1	0.960	-	-
	14	13.860