DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC2 and cut3

DIOPT Version :9

Sequence 1:	NP_610995.1	Gene:	SMC2 / 36653	FlyBaseID:	FBgn0027783	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_595392.1	Gene:	cut3 / 2539817	PomBaseID:	SPBC146.03c	Length:	1324	Species:	Schizosaccharomyces pombe

Alignment Length:	1327	Identity:	296/1327 - (22%)
Similarity:	553/1327 - (41%)	Gaps:	279/1327 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYVKKLVLDGFKSYGRRTEIEG-FDPEFTAITGLNGSGKSNILDSICFVLGI--SNLQNVRASAL 62
            :.|.:|.|..||||. .|:|.| |.|.|::|.|.|||||||::|::.||.|.  |.|:..:|||
pombe   124 LVVYELRLTNFKSYA-GTQIVGPFHPSFSSIVGPNGSGKSNVIDALLFVFGFRASKLRQSKASA- 186

  Fly    63 QDLVYKNG-QAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKK 126
              |::|:. ...:....|.|.|...|   ....|....|::|.|.......:|:.:||
pombe   187 --LIHKSATHPSLDSCDVEITFKEVN---SDFTYVDGSELTVRRTAYKNNTSKYFVNG------- 239

  Fly   127 VQDFFCSIQ-------LNVNNPNFLIMQGKIQQVLNMKPKEV-------LSMVEEAAGTSQYKTK 177
            |:..|.::.       :::|:..|||:||:::.:..|||:.:       |..:|:..|||:|
pombe   240 VESSFSAVSNLLKEKGIDLNHKRFLILQGEVESIAQMKPRAISEGDDGLLEYLEDIIGTSKY--- 301

  Fly   178 RDATKTLIEKKETKVRETKVLLDEE------VLPKLVKLRQERSAYQEYQKICRDIDFLIRIHIS 236
                |.:||:...::..:..:..|:      ||.:..||...:::...:.|...::
pombe   302 ----KPIIEENMQELSNSDDICAEKESRLKLVLSEKAKLEDSKNSVLSFLKDENEL--------- 353

  Fly   237 AKYLKQCETLKTV--EANEHK--IEDRIANCKATHAKNLAEVESIENSVKEMQQQIDA--EMGGS 295
              ::||.:..:|:  |....|  :::.:.:.:.....:|.:.|..|..:.|..:::.:  |....
pombe   354 --FMKQNQLYRTILYETRNKKTLVQNLLNSLEGKLQAHLEKFEQTERDISEKNEEVKSLREKAAK 416

  Fly   296 IKNLETQLSAKRALEATATGSLKAAQGTIQQDEKKIRMASKNIE-------DDERALAKKEADMA 353
            :||..|.....|......|..::.....:...|||::   |:||       :.|.:|:..:.|..
pombe   417 VKNDCTSEKKTRQSYEQQTVKIEEQLKFLLNKEKKLK---KSIEALSFEKSEAENSLSSHDIDSQ 478

  Fly   354 KVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLST----------------NE-NGEASTLQEQ 401
            |:..|...|.....::..:.:|.:|.|:..::|:|.                |: ..|...||.:
pombe   479 KLNSEIADLSLRLQQEELSLDDIRKSLQGKTEGISNAIEEKQKAMAPALEKINQLTSEKQILQVE 543

  Fly   402 LIVAKEQFSEAQTTIKTSEIELRHTRG--------------VLKQREGETQTNDAAYVKDKKLHD 452
            |.:...:.::....:::|:..|...|.              ||...:||.        ||..
pombe   544 LDMLLNKENDLINDVESSQSSLDKLRNDAEENRNILSSKLKVLSDLKGEK--------KDVS--- 597

  Fly   453 QLVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDR 517
                  ||:||:.:::.   ..:..|...|..|...|..|.....|.|... .||......|
pombe   598 ------KNIERKKETVH---NTYRNLMSNRTKLEEMKASLSSSRSRGNVLE-SLQRLHESDN--- 649

  Fly   518 RKVRGLVGKLFQVKDMQNSM-ALVQTAGGSLYSYVTDDDVTSKK---ILQRGNLQRRVTLIPINK 578
              :.|..|:|..:..:..:. ..:.||..:|...|.|:..|.:|   .|:..||.|...:|
pombe   650 --LNGFFGRLGDLATIDEAYDVAISTACPALNHIVVDNIETGQKCVAFLRSNNLGRASFII---- 708

  Fly   579 IQSGSLNRNVVEYAQNKVG----AENVQWAMSLIDY-DRYYEPVMKFCFGGTLICKDLIVAKQIS 638
                     :.|.||..:.    .|||.....|:.: |:.:.|........||:.|:|..|.:|:
pombe   709 ---------LKELAQKNLARIQTPENVPRLFDLLRFNDQKFAPAFYNVLQNTLVAKNLEQANRIA 764

  Fly   639 YDPRINCRSVTLEGDVVDPHGTVSGG----------------AAPKGANVLEELHAIKQIEKE-- 685
            |. :...|.|||.|.::|..||::||                .:|......:     ||::.|
pombe   765 YG-KTRWRVVTLSGQLIDKSGTMTGGGTRVKKGGMSSAITSDVSPASVETCD-----KQVQLEDT 823

  Fly   686 -YREIDSEIAQVEKQIASIENQ----ALAFNKMKENLDLRQHELTMCENRLA--QTTFQQNQAEI 743
             ||:..||:..:.::...|..:    .|..:|:       |.:::.|:..:|  :....|.::::
pombe   824 RYRQHLSELESLNQRFTEISERIPSAELEISKL-------QLDVSACDRLVAGEERRILQLKSDL 881

  Fly   744 EEMR---ERVKTLEQQIIDSREKQ---------------KTSQAKIVDIEAKLADAKGYRER--- 787
            :.:|   ||.:.|:.: |.:.:|:               ||.|.||::|       .|.|.|
pombe   882 KSIRNNNERKRNLQNK-ISNMDKEVEAININNEGLVTEIKTLQDKIMEI-------GGIRYRIQK 938

  Fly   788 -ELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAE 851
             :::....::|..|.:..|.....||.||..::.|:|::.|....:|.       .:::...|.|
pombe   939 SKVDDLHEQLKFVKDKLNKMSFKKKKNEQRSQSFQVELSNLTSEYDTT-------TESIATLKTE 996

  Fly   852 LDALKVNSSSAASEVTELEQAIKEQKDKLRD-------QNKEMRNQLVKKEKMLKENQEIE---- 905
            |.:|........|.:.|.|.|:.:....:.:       ::|:|.:  ||.|::..|||..|
pombe   997 LQSLNKYVDEHKSRLREFENALWDINSSIDELVKFIEFESKQMNS--VKAERIELENQIQEQRTA 1059

  Fly   906 -LEVKKKENEQKKISSDAKEAKKR----MEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGN 965
             .||...||:..|:.|:.|.....    ...:::.:|...|:           :.|..|..|..:
pombe  1060 LSEVGNNENKYLKLMSNLKLHNLTEFCDQTTMDSTFPEYSED-----------ELSSVDKSELVS 1113

  Fly   966 KLAKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEK---IKKIIVKMDEEEQDQ 1027
            .::.:::|.:..|..:|     ||.......||.|:|.:....:.:|   :||::..:..:..|:
pombe  1114 NISVLKKKTEDREVDIN-----VLSEYRRCNKEAEKRDSDYQSELQKRTDLKKVVTDLQSQRLDE 1173

  Fly  1028 LNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGI-----WKESLGELSGGQ 1087
            .......::.....::..:..|..|:|..|.:   |......|.|:.:     || ::..||||:
pombe  1174 FMYGFGIISMKLKEMYQIITMGGNAELELVDS---LDPFSEGVLFSVMPPKKSWK-NISNLSGGE 1234

  Fly  1088 KSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLFNHAN 1152
            |:|.:|:||.|:..:.|.|||::||:|||||..:...:.:.:|:...|:||:::||:..:|..::
pombe  1235 KTLSSLALVFALHNYKPTPLYVMDEIDAALDFKNVSIVANYIKERTKNAQFIVISLRSNMFELSS 1299

  Fly  1153 VLFRTLFEEGVSTITRQVSRQATTNKR 1179
            .|.      |:.. |..:::..|.|.:
pombe  1300 RLV------GIYK-TANMTKSVTINNK 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	293/1314 (22%)
		ABC_SMC2_euk	1..>170	CDD:213240	57/186 (31%)
		SMC_hinge	520..637	CDD:214944	29/125 (23%)
		V_Alix_like	690..933	CDD:187408	59/286 (21%)
		P-loop_NTPase	<1073..1167	CDD:304359	32/98 (33%)
cut3	NP_595392.1	ABC_SMC4_euk	124..>303	CDD:213241	61/199 (31%)
		Smc	128..1322	CDD:224117	295/1323 (22%)
		SMC_hinge	651..763	CDD:214944	29/124 (23%)
		ABC_SMC4_euk	<1218..1314	CDD:213241	33/103 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810