DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC2 and smc6

DIOPT Version :9

Sequence 1:	NP_610995.1	Gene:	SMC2 / 36653	FlyBaseID:	FBgn0027783	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_587906.1	Gene:	smc6 / 2539020	PomBaseID:	SPCC5E4.06	Length:	1140	Species:	Schizosaccharomyces pombe

Alignment Length:	1261	Identity:	263/1261 - (20%)
Similarity:	458/1261 - (36%)	Gaps:	379/1261 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 FDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVYKNGQAGITKATVTIVFDNTN 87
            |.|....:.|.||||||.||..:...||.......||..::.||    :.|...|.:::...|..
pombe   115 FGPRINFVIGHNGSGKSAILTGLTICLGAKASNTNRAPNMKSLV----KQGKNYARISVTISNRG 175

  Fly    88 -PAQCPQGYEKCREISVTRQVVVGGKNKFLI---NGKLVQNKKVQ-DFFCS-IQLNVNNPNFLIM 146
             .|..|:.|.|  .|::.|.:...|.:::.:   ||.::..|:.: |..|. :.|.::||..::.
pombe   176 FEAYQPEIYGK--SITIERTIRREGSSEYRLRSFNGTVISTKRDELDNICDHMGLQIDNPMNILT 238

  Fly   147 QGKIQQVL-NMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRETKVLLDEEVLPKLVKL 210
            |...:|.| |..|||
pombe   239 QDTARQFLGNSSPKE-------------------------------------------------- 253

  Fly   211 RQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIEDRIANCKATHAKNLAEVE 275
                    :||...:.|.                 ||.:|.|...||..:.|.|.........|.
pombe   254 --------KYQLFMKGIQ-----------------LKQLEENYSLIEQSLINTKNVLGNKKTGVS 293

  Fly   276 SIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQGTIQQDEKKIRMASKNIED 340
            .:  :.||.:.::..|.....:||...|..|:       |.:..||  :.:.||::.:|.|..:.
pombe   294 YL--AKKEEEYKLLWEQSRETENLHNLLEQKK-------GEMVWAQ--VVEVEKELLLAEKEFQH 347

  Fly   341 DERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLSTNE---NGEASTLQEQL 402
            .|..|:                            :|::.||::    .||:   :|:.|:.:|
pombe   348 AEVKLS----------------------------EAKENLESI----VTNQSDIDGKISSKEE-- 378

  Fly   403 IVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQLVVEIKNLERQLQS 467
                                      |:.:.:|||.|..:      |..|  :|:.
pombe   379 --------------------------VIGRAKGETDTTKS------KFED--IVKT--------- 400

  Fly   468 LDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDRRKVRGLVGKLFQVKD 532
                   |:..:...||:.::|||::..:   ||::..|.....:.|.:|.:...|.|.  |::.
pombe   401 -------FDGYRSEMNDVDIQKRDIQNSI---NAAKSCLDVYREQLNTERARENNLGGS--QIEK 453

  Fly   533 MQNSMALVQTAGGSLYSYVTD-----DDVTSKKILQRGNLQRRVTLIP--INKIQSGSLNRNVVE 590
            ..|....:|.....|...:.:     :|:.|..:...|||...:|...  .|||...|.:..|:|
pombe   454 RANESNNLQREIADLSEQIVELESKRNDLHSALLEMGGNLTSLLTKKDSIANKISDQSEHLKVLE 518

  Fly   591 YAQ-NKVGA--ENVQWAMSLIDYDRYYEPVMKFCFGGTLICKD----LIVAKQIS---------- 638
            ..| :||.|  :|:...:.||..:..::...|...|..:..|:    ||:.:.:.
pombe   519 DVQRDKVSAFGKNMPQLLKLITRETRFQHPPKGPMGKYMTVKEQKWHLIIERILGNVINGFIVRS 583

  Fly   639 -YDPRI--------NCRSVTLEGDVVDPHGTVSGGAAPKGANVL--------EELHAIKQ---IE 683
             :|..|        ||.:..:.|. .||....||....:...||        |.||.:..   ||
pombe   584 HHDQLILKELMRQSNCHATVVVGK-YDPFDYSSGEPDSQYPTVLKIIKFDDDEVLHTLINHLGIE 647

  Fly   684 K-----EYREIDSEIAQVEKQIASIENQALAFNKMKENLDLR----QHELTMCE----NRLAQTT 735
            |     :.||.:   |.:::.||:: .|..|.:........|    |....:.:    ||..:..
pombe   648 KMLLIEDRREAE---AYMKRGIANV-TQCYALDPRNRGYGFRIVSTQRSSGISKVTPWNRPPRIG 708

  Fly   736 FQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKLADAKGYRERELNAATNEIKVTK 800
            | .:...||        .|::|:|..:||....:..:: |||:..||..|:.:|       .|.|
pombe   709 F-SSSTSIE--------AEKKILDDLKKQYNFASNQLN-EAKIEQAKFKRDEQL-------LVEK 756

  Fly   801 QRAEKSRANWKKRE--------------QEFETLQLEITELQKSIET-------AKKQHQEMIDN 844
            ....|.|...|:||              ::.:||:..|:|.:|.:|:       ||.:...:.||
pombe   757 IEGIKKRILLKRREVNSLESQELSVLDTEKIQTLERRISETEKELESYAGQLQDAKNEEHRIRDN 821

  Fly   845 ----LEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNK------EMRNQLVK------ 893
                :|:.:...:.::..:...:|..|||        .:|||:.:      |...|.|:
pombe   822 QRPVIEEIRIYREKIQTETQRLSSLQTEL--------SRLRDEKRNSEVDIERHRQTVESCTNIL 878

  Fly   894 KEKMLKENQ--EIELEVKKKEN---EQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFG--MKNT 951
            :||..|:.|  ::..:...|.|   |:..:.....|....:|.|:.:   |.|.:|..|  ::..
pombe   879 REKEAKKVQCAQVVADYTAKANTRCERVPVQLSPAELDNEIERLQMQ---IAEWRNRTGVSVEQA 940

  Fly   952 RYDY--SKEDPHEAGNKLAKMQEKKDKMERTLNMNAIM-------VLDREEENFKETERRRNIVA 1007
            ..||  :||...:|...:|::.:....:|.||.....|       :..|.:|.|:....:||...
pombe   941 AEDYLNAKEKHDQAKVLVARLTQLLQALEETLRRRNEMWTKFRKLITLRTKELFELYLSQRNFTG 1005

  Fly  1008 MDKEKIKKIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGF 1072
                   |:::|..||   .|.......|.|.            |..:..|...       ||..
pombe  1006 -------KLVIKHQEE---FLEPRVYPANRNL------------ATAHNRHEKS-------KVSV 1041

  Fly  1073 NGIWKESLGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALD-MSHTQNIGSML--KQHFT 1134
            .|        ||||:||...:.::|::.:....||..|||.|..:| ::...:|..|:  .:..:
pombe  1042 QG--------LSGGEKSFATICMLLSIWEAMSCPLRCLDEFDVFMDAVNRLVSIKMMVDSAKDSS 1098

  Fly  1135 NSQFLIVSLKD----GLFNHANVLFR 1156
            :.||:.::.:|    ||.... |:||
pombe  1099 DKQFIFITPQDMGQIGLDKDV-VVFR 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	263/1261 (21%)
		ABC_SMC2_euk	1..>170	CDD:213240	42/153 (27%)
		SMC_hinge	520..637	CDD:214944	30/130 (23%)
		V_Alix_like	690..933	CDD:187408	61/292 (21%)
		P-loop_NTPase	<1073..1167	CDD:304359	25/91 (27%)
smc6	NP_587906.1	Smc	16..1128	CDD:224117	263/1261 (21%)
		ABC_SMC6_euk	97..>252	CDD:213243	39/142 (27%)
		ABC_SMC6_euk	<1034..1127	CDD:213243	28/106 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810