Protein Alignment SMC2 and Smc1a

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_062684.2
• Gene: Smc1a / 24061
• MGIID: 1344345
• Length: 1233
• Species: Mus musculus
• Alignment Length: 1302
• Identity: 300/1302 - (23%)
• Similarity: 586/1302 - (45%)
• Gaps: 211/1302 - (16%)

  Fly     2 YVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLV 66
            ::|.:.::.||||..|..|..|. .||||.|.|||||||::|:|.|||| ....|:|...|:||:
Mouse     3 FLKLIEIENFKSYKGRQIIGPFQ-RFTAIIGPNGSGKSNLMDAISFVLG-EKTSNLRVKTLRDLI 65

  Fly    67 Y--KNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQD 129
            :  ..|:....:|.|::|:.           |:..|.....:|:|||.:::.||.|:||..:..:
Mouse    66 HGAPVGKPAANRAFVSMVYS-----------EEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSE 119

  Fly   130 FFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKV-- 192
            ....:.:.:...|||:.||.::.:....|||..::.||.:.:.:...:.|..|..:.|.|...
Mouse   120 ELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQF 184

  Fly   193 ---RETKVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEH 254
               |:..:..:.:      :.:||:.....||::   .|.::|..:..:..|    |...|....
Mouse   185 NYHRKKNIAAERK------EAKQEKEEADRYQRL---KDEVVRAQVQLQLFK----LYHNEVEIE 236

  Fly   255 KIEDRIANCKATHAKNLAEVESIENSVKEM----------QQQIDAEMGGSIKNLETQLSAKRAL 309
            |:...:|:......|:...::.:|:.:||.          ||||:.|    ||..:::|:.||
Mouse   237 KLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKE----IKEKDSELNQKR-- 295

  Fly   310 EATATGSLKAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYE 374
                ...:||.:.| ....||:..|.|::::.::...|::.||.:::.|..|::       ||.:
Mouse   296 ----PQYIKAKENT-SHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVE-------KARQ 348

  Fly   375 DAQKKLEAVSQG----LSTNEN-------------GEASTLQEQLIVAKEQFSEAQTT----IKT 418
            :.::::|..||.    |:..||             ..|:||.::|    |:|:..|..    :..
Mouse   349 EFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQEL----EKFNRDQKADQDRLDL 409

  Fly   419 SEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQLVVEIKNLERQLQSLDYEGGHFEKLKQRRN 483
            .|.:...|...:||:..|.:.|..   :.:||.:.:....::||.|.:   .||...|:::..:.
Mouse   410 EERKKVETEAKIKQKLREIEENQK---RIEKLEEYITTSKQSLEEQKK---LEGELTEEVEMAKR 468

  Fly   484 DLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDRRK--------------VRGLVGKLFQVKDMQ 534
            .:....::|.:.:::...:|.|.|    |.:..:||              |.|.:..|.|....:
Mouse   469 RIDEINKELNQVMEQLGDARIDRQ----ESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKK 529

  Fly   535 NSMALVQTAGGSLYSYVTDDDVTSKKIL-----QRGNLQRRVTLIPINKIQSGSLNRNVVEYAQN 594
            ..:|:.:..|.::.:.:.|.:.|.:..:     |||..:   |.:|::.::        |:....
Mouse   530 YQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPE---TFLPLDYLE--------VKPTDE 583

  Fly   595 KVGAENVQWAMSLIDYDRYYEP----VMKFCFGGTLICKDLIVAKQISYDPRINCRSVTLEGDVV 655
            |:  ..::.|..:||..||..|    .:::..|..|:|.::..|::|::......::|.|:|.:.
Mouse   584 KL--RELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLF 646

  Fly   656 DPHGTVSGGAAPKGANVLE-ELHAIKQIEKEYREIDSEIAQ------VEKQIASIENQALAFNKM 713
            ...|.:||||:...|.... :..|:.:::::...:..|:.:      .|.::..:::||   :.:
Mouse   647 QKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQA---HGL 708

  Fly   714 KENLDLRQHELTMCENRLAQTTFQQN---QAEIEEMRERVKTLEQQIIDSREKQ-KTSQAKIVDI 774
            :..|...|.:|...:.|......|:.   ::|:.....|:..: ::||.|||:: |..:.|:..:
Mouse   709 QMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDI-KRIIQSREREMKDLKEKMNQV 772

  Fly   775 EAKLAD-------AKGYRERELNAATNEIKVTKQRAEKSRANWKKR---EQEFETLQLE------ 823
            |.::.:       .:..||.|......:.::.|:|.|..  |.|.|   :.:||..||:
Mouse   773 EDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFE--NQKTRLGIQLDFEKNQLKEDQDKV 835

  Fly   824 ------ITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRD 882
                  :.:.:..||..||:.|..:..:::..|:|..||....:..|||.:....::|.:.||..
Mouse   836 HMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGG 900

  Fly   883 QNKEM--------------------RNQLVKKEKMLKENQEIELEVKK---KENEQKKISSDAKE 924
            .||||                    |:.|::..||    |:|:|.:.|   .:..|::.||..:|
Mouse   901 ANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKM----QDIKLPLSKGTMDDISQEEGSSQGEE 961

  Fly   925 A---KKRMEALEAKYPWIPEEKN--CFGMKNTRYDYSKEDPHEAGNKLAKMQEKKDKMERTL--N 982
            :   .:|..::.|:...|..:..  |..:|:.:.:  :|...|......|:.|::..::|..  |
Mouse   962 SVSGSQRTSSIYAREALIEIDYGDLCEDLKDAQAE--EEIKQEMNTLQQKLNEQQSVLQRIAAPN 1024

  Fly   983 MNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLL 1047
            |.|:..|:...:.|:||...........:|.|:...::.:|..|:.|.....|.||...|:.:|.
Mouse  1025 MKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALS 1089

  Fly  1048 --PGAEAKLNPVH-TNGCLTGLEIKVGFNGIWKESLGELSGGQKSLVALSLVLAMLKFSPAPLYI 1109
              ..|:|.|.|.: ....|.|:.......|.....:..||||:|::.||:|:.|:..:.|||.::
Mouse  1090 RNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFV 1154

  Fly  1110 LDEVDAALDMSHTQNIGSMLKQHFT-NSQFLIVSLKDGLFNHANVLFRTLFEEGVSTITRQVSRQ 1173
            |||:|||||.::...:.:.:|:..| |.|.:::|||:..:..|..|.....|:|...|::.::..
Mouse  1155 LDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTKAESLIGVYPEQGDCVISKVLTFD 1219

  Fly  1174 AT 1175
            .|
Mouse  1220 LT 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	297/1287 (23%)
Smc1a	NP_062684.2	SMC_N	3..1210	CDD:426784	298/1289 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..308		8/30 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..369		4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	947..969		4/21 (19%)