Protein Alignment SMC2 and Rad50

DIOPT Version :9

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_033038.2
• Gene: Rad50 / 19360
• MGIID: 109292
• Length: 1312
• Species: Mus musculus
• Alignment Length: 1446
• Identity: 272/1446 - (18%)
• Similarity: 519/1446 - (35%)
• Gaps: 487/1446 - (33%)

  Fly     3 VKKLVLDGFKSYG---RRTEIEGFDPEFTAITGLNGSGKSNILDSICFVL---------GISNLQ 55
            ::|:.:.|.:|:|   :..:|..|....|.:.|.||:||:.|::.:.::.         |.:.:.
Mouse     4 IEKMSILGVRSFGIEDKDKQIISFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVH 68

  Fly    56 NVRASALQDLVYKNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGK 120
            :.:.:...|:          :|.:.:.|.:.|...          ::|.|.::...|||
Mouse    69 DPKVAQETDV----------RAQIRLQFRDVNGEM----------VAVHRSMLCSQKNK------ 107

  Fly   121 LVQNKKVQDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAA----------GTSQ-- 173
                               ...|..::|.|.:   ||..|.:|:..:.|          |.|:
Mouse   108 -------------------KTEFKTLEGVITR---MKHGEKVSLSSKCAEIDREMISCLGVSKSV 150

  Fly   174 -----YKTKRDATKTLIEKKETKVRETKVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRI 233
                 :..:.|:...|.|.|..|.:..::......:..|..|||.|..  :.||:
Mouse   151 LNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALDTLRQVRQT--QGQKV---------- 203

  Fly   234 HISAKYLKQCET-LKTVEANEHK---IEDRIANCKATHAKNLA-------EVESIENSVKEMQQQ 287
                   |:|:| ||.::.|:.|   |.|:|.:.:|..|.:..       |:|.::|.:||::..
Mouse   204 -------KECQTELKYLKQNKEKACEIRDQITSKEAQLASSQEIVRSYEDELEPLKNRLKEIEHN 261

  Fly   288 ID--AEMGGSIKNLETQLSAKRALEATATGSL-----KAAQGTIQQ-------DEKKIRMASKNI 338
            :.  .::...||.||   |.|:.:|.. ...|     |..|||.:|       .::.:|...:.:
Mouse   262 LSKIMKLDNEIKALE---SRKKQMEKD-NSELEQKMEKVFQGTDEQLNDLYHNHQRTVREKERRL 322

  Fly   339 EDDERALAK----------KEADMAKVQGEFESLKEAD-------ARDS---------------- 370
            .|.:|.|.|          ::|::...||..:  .:||       ||||
Mouse   323 VDCQRELEKLNKEARLLNQEKAELLVEQGRLQ--LQADRHQEHIRARDSLIQSLATHLELDGFER 385

  Fly   371 --------KAY-----EDAQKKLEAVSQGLSTNENGEASTLQEQLIVAKEQFS------EAQTTI 416
                    |.:     |..:::.:..||.||...:.|| ..|.||...:::.|      |.:|.|
Mouse   386 GPFSERQIKNFHELVKERQEREAKTASQLLSDLTDKEA-LKQRQLDELRDRKSGLGRTIELKTEI 449

  Fly   417 KT-SEIELRHTRGVLKQREGE-------------------------------------------- 436
            .| .:.||||.|..|:|.||.
Mouse   450 LTKKQSELRHVRSELQQLEGSSDRILELDQELTKAERELSKAEKNSSIETLKAEVMSLQNEKADL 514

  Fly   437 -------------------TQTNDAAYVKDKKLHDQLVVEIKNLERQLQSLDYEGGHFEKLKQRR 482
                               |:|......|||...|:.:.:||:  |....|....|:|...||..
Mouse   515 DRSLRKLDQEMEQLNHHTTTRTQMEMLTKDKTDKDEQIRKIKS--RHSDELTSLLGYFPNKKQLE 577

  Fly   483 NDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDRRKVR-------GLVGKLFQV---KDMQNSM 537
            :.||.:.:::.:..||......:|...:...|....:::       ....|||.|   :|:::.:
Mouse   578 DWLHSKSKEINQTRDRLAKLNKELASAEQNKNHINNELKKKEEQLSSYEDKLFDVCGSQDLESDL 642

  Fly   538 ALVQ------------TAGG-SLYS----YVTDDDVTSKKILQR------------GNLQRRVTL 573
            ..::            .||. ::||    .:||::.:...:.||            .:||.::.|
Mouse   643 GRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRL 707

  Fly   574 IPINKIQSGSLNRNVVEYAQNK-VGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQI 637
            .| :|::|........|..::: :|...|:  .|:||                      :..|:|
Mouse   708 AP-DKLKSTESELKKKERRRDEMLGLVPVR--QSIID----------------------LKEKEI 747

  Fly   638 SYDPRINCRSVTLEGDV------VDPHGTVSGGAAP--KGANV-LEELHAIKQIEKEYREIDSEI 693
               |.:..|..::..|:      ::...|:.|...|  :.|.| |.::..:::.:.|.::::.:|
Mouse   748 ---PELRNRLQSVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKI 809

  Fly   694 AQVEKQIASIENQALAFNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQII 758
            ||   |.|.:           :.:||             ..|.||...|.:|.:.|:.|:..:|.
Mouse   810 AQ---QAAKL-----------QGVDL-------------DRTVQQVNQEKQEKQHRLDTVTSKIE 847

  Fly   759 DSREKQKTSQAKIVDIEAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLE 823
            .:|:..:..|.:|..:::|               |||:|..|.:...:....::.|::...|..|
Mouse   848 LNRKLIQDQQEQIQHLKSK---------------TNELKSEKLQIATNLQRRQQMEEQSVELSTE 897

  Fly   824 ITELQKSIETAKKQHQEMIDNLEKFKAELDAL----KVNSSSAASEVTELEQAIKEQKDKLRDQN 884
            :..|.:.|:.||:|...:...|||.:.|.:.|    ..::..|..::.:    |||:...:....
Mouse   898 VQSLNREIKDAKEQISPLETALEKLQQEKEELIHRKHTSNKMAQDKIND----IKEKVKNIHGYM 958

  Fly   885 KEMRNQLVKKEKMLKENQEIEL-----EVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKN 944
            |::.|.:...:...|:.:|.||     ::.:.|..::||:.|....::.::..:.:..|:.:...
Mouse   959 KDIENYIQDGKDDYKKQKETELNGVAVQLNECEKHREKINKDMGTMRQDIDTQKIQERWLQDNLT 1023

  Fly   945 CFGMKNTRYDYSKEDPHEAGNKL--------AKMQEKKDKMER---TLNMNAIMVLDRE------ 992
            .    ..|.|..||...|....|        .:|:.:..|:|.   |:..|..:.|.|:
Mouse  1024 L----RKRRDELKEVEEERKQHLKEMGQMQVLQMKNEHQKLEENIDTIKRNHSLALGRQKGYEDE 1084

  Fly   993 ---------EENFKETE---RRRNIVAMDKEKIKK-----------IIVKMDEEEQDQLNKAATE 1034
                     |..|::.|   |...||....|.:.|           .|:|....:.:::||...:
Mouse  1085 ILHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRD 1149

  Fly  1035 V------------------------------NTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIK 1069
            :                              |.|:..:   :|.|.             |.|:::
Mouse  1150 LWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVV---MLKGD-------------TALDMR 1198

  Fly  1070 VGFNGIWKESLGELSGGQKSLVALSLVLAMLK--FSPAPLYILDEVDAALDMSHTQNIGSML--- 1129
                       |..|.|||.|.:|.:.||:.:  .....:..|||....||..:.:::...|
Mouse  1199 -----------GRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEI 1252

  Fly  1130 ---KQHFTNSQFLIVS 1142
               :....|.|.|:::
Mouse  1253 IKSRSQQRNFQLLVIT 1268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	272/1446 (19%)
		ABC_SMC2_euk	1..>170	CDD:213240	31/188 (16%)
		SMC_hinge	520..637	CDD:214944	26/156 (17%)
		V_Alix_like	690..933	CDD:187408	51/251 (20%)
		P-loop_NTPase	<1073..1167	CDD:304359	18/78 (23%)
Rad50	NP_033038.2	Rad50_zn_hook	659..709	CDD:282302	11/49 (22%)
		DUF342	<893..1002	CDD:302792	26/112 (23%)
		ABC_Rad50	<1195..1297	CDD:213207	19/85 (22%)
		rad50	2..1312	CDD:129694	272/1446 (19%)
		ABC_Rad50	4..>166	CDD:213207	34/209 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910