Protein Alignment SMC2 and smc-4

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_497935.1
• Gene: smc-4 / 175603
• WormBaseID: WBGene00004874
• Length: 1549
• Species: Caenorhabditis elegans
• Alignment Length: 1338
• Identity: 309/1338 - (23%)
• Similarity: 564/1338 - (42%)
• Gaps: 231/1338 - (17%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            :.::.:.:|.||||..:..|..|...||:|.|.|||||||::||:.||.|. ....:|::.:.:|
 Worm    90 LMIRNVEVDNFKSYFGKASIGPFHKSFTSIIGPNGSGKSNLIDSLLFVFGF-RASKIRSAKVSNL 153

  Fly    66 VYKNGQAGITKATVTIVFDNTNPAQCPQGYE--KCREISVTRQVVVGGKNKFLINGKLVQNKKVQ 128
            ::|:......|.||||.|...  ...|..||  |..|.:::|.......:.:.|:|:.....:|:
 Worm   154 IHKSAGRNPDKCTVTIHFQRI--VDIPGHYEVVKDSEFTISRTAFQNNSSSYAIDGRPATKNEVE 216

  Fly   129 DFFCSIQLNVNNPNFLIMQGKIQQVLNMKP----KEVLSMV---EEAAGTSQYKT-----KRDAT 181
            .....:.:::.:..|||:||:::|:..|||    |....||   |:..||::.:.     :|...
 Worm   217 ARLRRVDIDIEHNRFLILQGEVEQIAMMKPVKTTKSETGMVEYLEDIIGTNRLEPFVKLFQRRVN 281

  Fly   182 KTLIEKKETKV-----RETKVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLK 241
            :...:..:.::     |.:||.::..|...:..|.:|..|              ..||:..:..:
 Worm   282 RLTCDLSQQRIARDHARNSKVAMENPVRAAIEFLMKENEA--------------TTIHMKLEQRR 332

  Fly   242 QCETLKTV---EANEHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQL 303
            :...|..:   :|...|:::.:.:...|...|..|.:..|.:.|.|.:: .:::..:..:|..:|
 Worm   333 RQRYLDKIAPKQAELDKMKEEMKSIAETLDTNKNEYKQSEEAQKVMIEE-RSKLDKNFDSLSKEL 396

  Fly   304 SAKRALEATATGSLKAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESL------ 362
            |.....|.....:||..|..|.:.|.:.....|...:.|.|..|.|..:||.|.|.|.|
 Worm   397 SDLGTEETRRKEALKRHQANISKAEAEKEKEVKKRSNLEAAPEKAERKIAKCQEEVEQLLEIEKT 461

  Fly   363 --KEAD------ARDSKAYEDAQKKLEAVSQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTS 419
              :|||      .:.|:|.::.|||:    |.....::.|.:.::.:..:|:|.|.:.:....:.
 Worm   462 ANEEADKNLDEFEKRSEAPKEEQKKI----QETWAQKSNEFNKVRGEARIAREDFEDLKKLANSG 522

  Fly   420 EIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQLVVEIKNLERQLQSLDYEGGHFEKLKQRRND 484
            ..:|..    ||:|   .::::.:|.|:|...|:|..|..:...:|:.|..|      |...||.
 Worm   523 TDKLIE----LKKR---LESSEESYAKEKDELDKLKPEFDSWNDKLKQLSTE------LPTLRNT 574

  Fly   485 LHMRKRDLKRELDR----------CNASRYDLQYQDPEPNFDR-RKVRGLVGKLFQVKDMQNSMA 538
            ...:.:||.:..||          |::|...:|....|....| :...|.:|.| .|.|.:...|
 Worm   575 ARQKNQDLAKTRDRLETLRQQNSSCSSSNKVIQALMKEKEAGRIKSFHGRLGDL-GVIDPKYEGA 638

  Fly   539 LVQTAGGSLYSYVTDDDVTSKKILQ--RGNLQRRVTLIPINKIQSGSLNRNVVEYAQNKVGAENV 601
            :....|..|...:...:..:|.::.  ..|...|.|:.|::||:..  .|::.....|.:.|..:
 Worm   639 ICTNFGARLNYLIVGKEEDAKNVINFLVANKLPRQTVQPLDKIKCD--KRDLAPNPTNPLPAPRL 701

  Fly   602 QWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRIN----CRSV---TLEGDVVDPHG 659
               :.|||.|    ||:|..|..  :.:..||........|::    ||.|   ||||.::.|.|
 Worm   702 ---IDLIDCD----PVLKPAFYD--MVRSAIVGDSTQEAQRMHRMPACRGVTVCTLEGSMIHPSG 757

  Fly   660 TVSGGA-APKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQALAFNKMKENLDLRQHE 723
            :.:||. ..||..:.::....||:..|.:..:.::|:   ::..:.::|       :.|..::||
 Worm   758 SFTGGGKTVKGLILTDKNKMAKQVTPEDKAAERDLAE---KLGKLRDEA-------DELKGQEHE 812

  Fly   724 L-----------TMCENRLAQTT--FQQNQAEIEEMRERVKTLEQQIIDSREKQKT--SQAKIVD 773
            :           ....|||:..|  .|.....||.:::.:...|::....:...||  .:.|||:
 Worm   813 MDGQLIEARRKVAEMSNRLSIVTSSVQSAAPAIETLKKTIANQEKEAAKVKVDAKTLEDKQKIVE 877

  Fly   774 IEAKLADAKGYRERELNAATNEIK-----VTKQRAEKSRANWKKREQEFETLQLEITELQKSIET 833
            ...|..|..|....::.|...||:     :.|:..:..|...|:..|:.:.|:.:|.:...:|..
 Worm   878 ELEKKRDELGEEAAKVKARQAEIQSKLDGIFKELVQCHRDEAKESLQKRQKLEKDIAKETANISN 942

  Fly   834 AKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKEKML 898
            :.:...:..:|:.:...:::.:|........:..: ::.:|.:|:.:....|:::....|.|:|.
 Worm   943 SGRNIAKCDENISRHDKDIEKMKKKCEELMEKAID-DEEVKSKKETVERFEKQIKKLQTKGEEMT 1006

  Fly   899 KENQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNT---RYDYSKEDP 960
            |:..|:.....|.|.|.||.|...||.|:.|.|...|...|  ||....:|..   |:.:..|..
 Worm  1007 KKQSELSAAETKLEGELKKCSEGIKELKESMLADRLKVEDI--EKKLAALKVNRIPRFQFLIESS 1069

  Fly   961 H------EAGNKLAKMQEKK--DKMERTLNMNAIMVLD--------REEENFKETERRRNIVAMD 1009
            .      :..:|:..:.|.:  :::||.....|.::.|        ..::..:.||...|:...|
 Worm  1070 RPEDLEMQIDDKMPVVDENQSPEEVERQKKHMACVMSDAAYALEFEMRQKVLENTESYENVDGED 1134

  Fly  1010 K--------EKIKKIIVKMDEEEQDQLN------------------KA----------------- 1031
            :        |||.:|..:..||.|.:|.                  ||
 Worm  1135 RVPVELLSDEKINEISSRDAEEMQMKLKVCEQQVEALKAKVDISSIKAYVDKVKQYNEQVIKLTI 1199

  Fly  1032 ATEVNT---------------------NFSG-----IFSSLLPGAEAKLNPVHTNGCL-TGLEIK 1069
            ||||:.                     .|.|     :|..|..|.:|||..:..:... .|:...
 Worm  1200 ATEVHRKHNQELQRIKQMRLEEFHSAFEFIGKHLVAVFKMLTDGGDAKLEYIDKDDPFRQGISFM 1264

  Fly  1070 V-GFNGIWKESLGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHF 1133
            | .....||: :..||||:|:|.:|:|:.|:..|.|.|.|::||:|||||..:...|...::|..
 Worm  1265 VRPAKKAWKQ-IQFLSGGEKTLSSLALIFALHMFRPTPFYVMDEIDAALDYRNVSIIAQYVRQKT 1328

  Fly  1134 TNSQFLIVSLKDGLFNHANVLFRTLFEEGVSTITRQVS 1171
            .|:||:|:||::.:|..||.|......:|   .||.|:
 Worm  1329 ENAQFIIISLRNNMFELANRLVGIYKVDG---CTRNVA 1363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	305/1326 (23%)
smc-4	NP_497935.1	SMC_N	91..1361	CDD:426784	307/1333 (23%)