Protein Alignment SMC2 and mix-1

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_496331.1
• Gene: mix-1 / 174669
• WormBaseID: WBGene00003367
• Length: 1244
• Species: Caenorhabditis elegans
• Alignment Length: 1255
• Identity: 404/1255 - (32%)
• Similarity: 631/1255 - (50%)
• Gaps: 157/1255 - (12%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            |::|.:.|||||||.:.|:|..|.|.|.||||.||||||||||||||::||:.|.|:||.::.:|
 Worm     1 MHIKSIHLDGFKSYQKHTDILDFSPTFNAITGYNGSGKSNILDSICFIMGINKLDNIRAKSMHEL 65

  Fly    66 VYKNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVV-----GGKNKFLINGKLVQNK 125
            :...|    |||.|.:.||||:....|.|.|...||.|.|.:..     |....:.:||....|.
 Worm    66 ISHGG----TKAIVQVRFDNTDKRCSPFGMEHLDEIVVQRIITAQATGKGCATSYTLNGHAATNG 126

  Fly   126 KVQDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQY-KTKRDATKTLIEKKE 189
            |:||||..:.||||||:||||||:|..||||||:|:|.||||||||..| :.|:||.||:. .|:
 Worm   127 KMQDFFRGVGLNVNNPHFLIMQGRITTVLNMKPEEILGMVEEAAGTKMYDQKKKDAEKTMF-LKD 190

  Fly   190 TKVRETKVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEH 254
            .|::|...:....:.|::||.|::|....|..::.:..:...|.:.:.:|.:.||.:|
 Worm   191 AKLKEVDRIFQSSIDPRMVKFREDRKNMVEVTRLKKLKENFSRKYEAFQYFQTCEAVK------- 248

  Fly   255 KIEDRIANCKATHAKNLAEVESIENSVKEMQQ---QIDAEMGGSIKNLETQLSAKRALEAT---- 312
                          |:..|:|..:..::::.:   |:|.:    :||.|.:   |:.:|.:
 Worm   249 --------------KSAKEIEDAKKGIEDLGEKFNQLDLD----LKNKEDE---KKKMEESRDDQ 292

  Fly   313 -ATGSLKAA----QGTIQQDE-------KKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEA 365
             ...:|.||    |..:.|.|       :.|....|..|...::|:|....:...:.|.|..|.|
 Worm   293 HEEAALSAAHLSKQSIMLQKETVKNQLVETINKLKKEGEQINKSLSKDREVLDAKRKEHEDSKAA 357

  Fly   366 DARDSKAYEDAQ-------KKLEAVSQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIEL 423
            :::|.::..|.:       ..||::::|...|:.||..:::.::...|...|:..:.|..::...
 Worm   358 NSKDIQSQSDDEALVTKYRNDLESLTRGTIANDKGEHVSIESEIQSCKSTASQMSSGITAAKKRG 422

  Fly   424 RHTRGVLKQREGETQTNDAAYVKDKKLHDQLVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMR 488
            ......:|..|||..|..|....|....|....|:..:.:|||.|.:......:.::....||..
 Worm   423 ERLHNQIKHLEGEKATLSARSKSDIGSADNYQKEVDEINKQLQLLGFNIDADTEKREHAAKLHES 487

  Fly   489 KRDLK----RELDRCNASRYDLQYQDPEPNFD----RRKVRGLVGKLFQVKD--MQNSMALVQTA 543
            ...||    |.|:.....||.|.||.|..:.|    :|.|.|.|..|.::|.  .|.::|.....
 Worm   488 ITKLKDMDTRLLNSYKDGRYALNYQRPPLHIDKFDEKRDVFGYVAHLIKMKPGCEQFAVAADIAL 552

  Fly   544 GGSLYSYVTDDDVTSKKILQRGNLQRRVTLIPI--NKIQSGSLN-------RNVVEYAQNKVGAE 599
            ||.|.:.|......::.::.......|.|:||:  |...:.|.|       |...|.|:..  .:
 Worm   553 GGVLGNVVVSTQDIARILIDGKAFTSRKTMIPVSENARNASSYNTLPDVKLRRAKEIAEKY--ND 615

  Fly   600 NVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRSVTLEGDVVDPHGTVSGG 664
            .|...:.||:|..:....:....|..|:...|.||::|:||.....|.:|..||.|..:|.::||
 Worm   616 TVTKMIDLIEYPDFISNTILNAVGQILVVDSLDVAREIAYDEVAKTRMITRRGDDVRTNGIMTGG 680

  Fly   665 AAPKGAN----VLEELHAIK-QIEKEYREIDSEIAQVEKQIAS------IENQ-ALAFNKM---K 714
            ....|..    .||.::|.: |||.:.||:|:...:::...||      :.|| |.|..|:   |
 Worm   681 YNDPGNKPALIALEPMYARRPQIEAQQRELDALNRELQLTEASSQKCRDLNNQLATAMRKLAQVK 745

  Fly   715 ENLDLRQHELTMCENRLAQTTFQQNQAEIE-------EMRERVKTLEQQIIDSREKQKTSQAKIV 772
            .|::..:..:.:.:.::....:::||||||       ::.:::||||..    :.|.|.||.|
 Worm   746 TNINNSEFGIVVRDLKVHSEEYEKNQAEIEATVKTLKDVEDKIKTLESM----KNKDKNSQEK-- 804

  Fly   773 DIEAKLADAKGYRERELNA----ATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQKSI-- 831
                        |::||.|    |...:...|.|.||:|       :|...||..:.|::|:|
 Worm   805 ------------RKKELTALLQKAEQTVAQNKNRGEKAR-------REVMLLQATVEEMEKTIKK 850

  Fly   832 -ETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKE 895
             |...:|.::..|.||:        |:.::.||.:..||||  |..:.||.|.....|....:..
 Worm   851 DEGIWEQKKKECDELEE--------KLPNAIAALKDAELEQ--KAAQAKLNDLKNNQRQISTRLG 905

  Fly   896 KMLKE-----NQEIELEVKKKENEQKKISSDAKEAKKRMEALE--AKYPWIPEEKNCFGMKNTRY 953
            |:.||     .::.:.:.|::|.|::..|....||..|.||..  .|:.|:.:|:..|..|...|
 Worm   906 KIAKECDALIREKAKTKSKREEKEKELTSLQQSEASNRKEARSKLKKFEWLSDEEAHFNKKGGLY 970

  Fly   954 DYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIV 1018
            |:......:..:::.::.:|.:.:||:..:..:..||..|....:.:.:|..:..|...:||.|.
 Worm   971 DFEGYTVSKGKDEIKELTDKIETLERSCCIQNVSNLDTCEAKVLDIKNKRERITEDFNMLKKTIA 1035

  Fly  1019 KMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGIWKESLGEL 1083
            .:|:::.|:|.:|...||.:|..||:.|||.|.|.|.|........|||:||.|.|:.|:||.||
 Worm  1036 TLDKKKVDELIRAHESVNKDFGQIFNCLLPDAHASLVPPEGKTVCEGLEVKVSFGGVVKDSLHEL 1100

  Fly  1084 SGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLF 1148
            ||||:|||||||:||||||.|||||||||||||||:|||.|||.|:|.||.::||:|||||.|:|
 Worm  1101 SGGQRSLVALSLILAMLKFKPAPLYILDEVDAALDLSHTANIGMMIKTHFHHNQFIIVSLKQGMF 1165

  Fly  1149 NHANVLFRTLFEEGVSTITR 1168
            ::|:|||:|.|.:|.||.||
 Worm  1166 SNADVLFQTRFADGHSTCTR 1185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	398/1246 (32%)
mix-1	NP_496331.1	SMC_N	2..1182	CDD:481474	399/1249 (32%)