Protein Alignment SMC2 and smc-5

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_494935.1
• Gene: smc-5 / 173874
• WormBaseID: WBGene00016151
• Length: 1076
• Species: Caenorhabditis elegans
• Alignment Length: 1245
• Identity: 252/1245 - (20%)
• Similarity: 478/1245 - (38%)
• Gaps: 322/1245 - (25%)

  Fly     5 KLVLDGFKSYGRRTEIEGFDP--EFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVY 67
            ::|...|.:|    |...|.|  ....|.|.||||||:|:..||...|.|.....|:..:.:.:
 Worm    24 RVVFHNFLTY----EHTSFLPTASLNMILGHNGSGKSSIICGICLACGGSPKSLGRSERIVEYI- 83

  Fly    68 KNGQAGITKATVTIVFDNTNPAQCPQGY------EKCREISVTRQVV-VGGKNKFLINGKLVQNK 125
            ::|                    |.:||      :|.:...|.|..: ||.:.|:.:|.......
 Worm    84 RHG--------------------CTEGYVEIAIADKQKGPQVVRLTIRVGEQPKYRLNDSATTQS 128

  Fly   126 KVQDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGT---SQY----KTKRDATKT 183
            ::.|......:.::||...:.|.|::........|:|...|:||..   .|:    |.:.|:| :
 Worm   129 EIADLRKHYNIQIDNPCAFLAQDKVKSFSEQSSIELLRNTEKAASADLDQQHIDLMKQREDST-S 192

  Fly   184 LIEKKETKVRETKVLLDE--EVLP-------KL-----VKLRQERSAYQEYQKICRDIDFLIRIH 234
            :.:|..|.....|.|.||  :::|       ||     ::|.:::....|::|..|:
 Worm   193 IEDKCTTSENAIKRLEDEIGKIMPLVENYRKKLALQSKLRLLEKKMKIMEFEKFDRE-------- 249

  Fly   235 ISAKYLKQCETLKTVEANEHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNL 299
                |..:.:.:........::|..||.|: .|.|||      |:.:|:.:.|| ::|..|...:
 Worm   250 ----YKAELQNMDGAMIEYREVEKSIAECE-KHRKNL------EDRIKKDRSQI-SQMQRSCNEI 302

  Fly   300 ETQLSAKRALEATATGSLKAAQGTIQQDEKKIRMASKNIEDDERAL--AKKEADMAKVQGEFESL 362
            ..::..|        |..|..:..:|:.:.|:..|.|..:..|:.:  |:|..|.|:.:     |
 Worm   303 LAKVQEK--------GDKKLMEDMMQRAKAKLESAKKAADQHEKDVEKARKMIDQARAR-----L 354

  Fly   363 KEADARDSKAYEDAQKKLEAVSQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTR 427
            :|| ......||:.|.:::::.|..||   .|..:.||:..:.|:.:            |:|...
 Worm   355 QEA-VDTLNGYEEFQSEMKSLEQKYST---AERDSRQEEDAIQKKSY------------EMRQLE 403

  Fly   428 GVLKQREGETQTNDAAYVKDKKLHDQLVVEIKNLERQLQSLDYEGG-----HFEKLKQRRNDLHM 487
            ...:..|..:|.|.                 ::..|.||:...:..     :.:...|.:.|::|
 Worm   404 NKKRDEEQNSQLNR-----------------QDRYRVLQNFSSDASKAYRWYQQNRSQFKGDVYM 451

  Fly   488 RKRDLKRELDRCNASRYDLQYQDPEPNFDRRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVT 552
                          ...|:..:.||                ..|.::||:. |:.....:..|..
 Worm   452 --------------PIMDMVLKTPE----------------AAKALENSVG-VRDRTMFVCCYKE 485

  Fly   553 DDDVTSKKILQRGNLQRRVTLIPINKIQS--------GSLNRNVVEYAQNK---VGAENVQWAMS 606
            |:.:.:.|   :.:.:...:::|..||.|        ..|:|...:|..:.   ..|...|:..:
 Worm   486 DELLINGK---QHSWRINTSVVPAEKIYSEDIDAQLPSELSRLGFKYLVSNCFDAPAPLKQFLCN 547

  Fly   607 LIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRSVTLEGDVVDPHGTVSGGAAPKGAN 671
            :...:|       ..|||:.:.|.:....|.....|.   ||.|..::     ......:....|
 Worm   548 VSGLNR-------IPFGGSDVEKKIAEVSQAIEQTRY---SVFLTANI-----RCQNSKSRYANN 597

  Fly   672 VLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQAL-AFNKMKENLDLRQHELTMCENRLAQTT 735
            .|:...|.:: ...:|:...:::.|.|:   .:|..| ...|:|..:|:|..:|
 Worm   598 TLQSQSATRE-ANTWRDQFFKVSPVAKR---TDNSILEEIQKLKAEIDIRSEQL----------- 647

  Fly   736 FQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKLADAKGYRERELNAATNEIKVTK 800
             ::.:..|::.|:   .|.|:.:..:.|::.......::.:::|        :|.|..||: |..
 Worm   648 -REKRGAIQKERD---VLRQEQMQWKSKKQVHTKWKTELASEMA--------KLEALENEV-VDI 699

  Fly   801 QRAEKSRANWKKREQEFETLQLEITELQKSIETAKKQHQEMID-----NLEKFKAELDALKVNSS 860
            ...|:..||.:|:         .|.|.:|.:|.:.:.|:|:||     .:.:....:...:||.|
 Worm   700 SAIEEEYANVEKK---------AILETKKMLENSIRWHKEIIDKHRLIGIFELSESICKSRVNKS 755

  Fly   861 SAASEV--TELEQAIKEQKDKLRDQNKEMRNQLVKK---EKMLKENQEIELEVKKKENEQKKISS 920
            ::.:|.  ::||. :|..||...|..|...|.  ||   ..::||.....|:..|....:.||.|
 Worm   756 NSEAETHRSKLED-LKSVKDAAEDLLKTALNH--KKAAASALMKECSLKTLDESKMSPAENKIYS 817

  Fly   921 DAKEAKKRMEALEAKYPWIPEEKNCFGM----KNTRYDYSKEDPHEAGNKLAKMQEKKDKMERTL 981
               ...|..|..:     :|.:.|....    :.||...: ||..|.|:.:.:.:.|
 Worm   818 ---SLVKMFEEAD-----VPTDMNTLDQAITSEKTRLKLA-EDSGEDGSIVHEQRLK-------- 865

  Fly   982 NMNAIMVLDREEENFKETERRRNIVAMDKEKIKKII---VKMDEEEQDQLNKAATEV-------N 1036
                  |||.:             :.::|.:.:|:|   .::.::..|::|....||       |
 Worm   866 ------VLDDD-------------LVLEKTRQEKLIENRARIHDKLGDEINNWRKEVETMIEQIN 911

  Fly  1037 TNFSGIFSSLLPGAEAKL----NPVHTNGCLTGLEIKVGFNGIWKESLGEL-----SGGQKSLVA 1092
            .|:...|.||....|..|    ||:...  ..|:.|.|.|..  .||:..|     |||::|:..
 Worm   912 VNYVQFFDSLGCRGEVSLEVPENPLDIE--KYGIMIMVCFRK--GESMKRLDNKVQSGGERSVAT 972

  Fly  1093 LSLVLAMLKFSPAPLYILDEVDAALDMSHTQNI------------GSMLKQHFTNSQFLIVS--L 1143
            :..:||:.:..|.|...:||::..:|.::.:.:            |::.|     :|:.::|  |
 Worm   973 MLYLLALQQLCPVPFRCIDEINQGMDPTNERKVFDIMVGMWNGTTGTLSK-----TQYFLLSPKL 1032

  Fly  1144 KDGLFNHANV 1153
            ..||....||
 Worm  1033 LHGLDMRENV 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	252/1245 (20%)
smc-5	NP_494935.1	P-loop containing Nucleoside Triphosphate Hydrolases	20..>180	CDD:476819	41/180 (23%)
		SMC_prok_B	165..1001	CDD:274008	206/1031 (20%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<947..1052	CDD:476819	25/103 (24%)