DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC2 and Smc3

DIOPT Version :9

Sequence 1:	NP_610995.1	Gene:	SMC2 / 36653	FlyBaseID:	FBgn0027783	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_031816.2	Gene:	Smc3 / 13006	MGIID:	1339795	Length:	1217	Species:	Mus musculus

Alignment Length:	1311	Identity:	319/1311 - (24%)
Similarity:	583/1311 - (44%)	Gaps:	243/1311 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            ||:|::::.||:||..:|.::.|..:...|.|.|||||||...:|.|||. ....::|......|
Mouse     1 MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLS-DEFSHLRPEQRLAL 64

  Fly    66 VYKNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDF 130
            :::.....:..|.|.|:|||:: .:.|...|   |:|: |:|:...|:::.::.|:|....|.:.
Mouse    65 LHEGTGPRVISAFVEIIFDNSD-NRLPIDKE---EVSL-RRVIGAKKDQYFLDKKMVTKNDVMNL 124

  Fly   131 FCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRET 195
            ..|...:.:||.:::.||||.|:......:.|.::.|.|||..|..:::.:.:|:::.|.|..:.
Mouse   125 LESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKI 189

  Fly   196 KVLLD--EEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANE--HKI 256
            ..||.  ||.|..|.:.::|.:.||::.|:.|.:::               |:...|.||  .|:
Mouse   190 NELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEY---------------TIYNQELNETRAKL 239

  Fly   257 EDRIANCKATHAKNLA----------EVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKR---- 307
            ::..|..:.:..|:..          ::|.||..|:|::.:|.|     :|..:.||||:|
Mouse   240 DELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISA-----MKEEKEQLSAERQEQI 299

  Fly   308 ----ALEATATGSLKAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADAR 368
                .||..|........|..:|.::.::...|.:|..|    :|:.::|:.:.:|.|:||.:.|
Mouse   300 KQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIE----EKQKELAETEPKFNSVKEKEER 360

  Fly   369 D-SKAYEDAQKKLEA-VSQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLK 431
            . ::..:..|::.:. ..||    ...:.::.:|:....|::.......|...:.::......|:
Mouse   361 GIARLAQATQERTDLYAKQG----RGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLE 421

  Fly   432 QREGETQTNDAAYVK-DKKLH---------DQLVVEIKNLERQLQS-LDY----EGGHFEKLKQR 481
            ..|...:.|...|.| |:.|:         |:...|:||.:.:||| .:|    |....:.|..:
Mouse   422 DTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAK 486

  Fly   482 RNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDRRKV--------RGLVGKLFQVKDMQNSMA 538
            |.||..:::.|:....:...:..|...:..| :|.|:.:        .|:|...|:.:....:..
Mouse   487 REDLEKKQQLLRAATGKAILNGIDSINKVLE-HFRRKGINQHVQNGYHGIVMNNFECEPAFYTCV 550

  Fly   539 LVQTAGGSLYSYVTDDDVTSKKIL---QRGNLQRRVTLIPINKIQSGSLNRNVVEYAQNKVGAEN 600
            .| |||..|:.::.|.|..|.|||   .:.||...||.:|:||     |:.....|.:.......
Mouse   551 EV-TAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNK-----LDVRDTAYPETNDAIPM 609

  Fly   601 VQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRSVTLEGDVVDPHGTVSGGA 665
            :    |.:.|:..::...|..||.||||:.:.|:.|::....::|  :|||||.|...|.::||.
Mouse   610 I----SKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDC--ITLEGDQVSHRGALTGGY 668

  Fly   666 APKGANVLEELHAIKQIEKEYRE---------------IDSEIAQVEKQIASIENQALAFNKMKE 715
            .....:.||....:::.|:|..|               |::||.|:..|:..||.|.   .|.|.
Mouse   669 YDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQ---RKFKA 730

  Fly   716 NLDLRQHELTMCENRLAQT--TFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKL 778
            :.|....|:.|.:.:..|:  ||...|..::.:...:..:|    .:||..|......:..:..|
Mouse   731 SRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAME----STRESLKAELGTDLLSQLSL 791

  Fly   779 ADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLE--IT--------ELQKSIET 833
            .|     ::.::|..:||:..:|         :.|:...|.::||  ||        .|:|.::.
Mouse   792 ED-----QKRVDALNDEIRQLQQ---------ENRQLLNERIKLEGIITRVETYLNENLRKRLDQ 842

  Fly   834 AKKQHQEMIDN-----LEKFKAELDAL--KVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQL 891
            .:::..|:.:.     |....:||:|:  :|..:.|.||  :|:.:|    ||.....||::..:
Mouse   843 VEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSE--DLDNSI----DKTEAGIKELQKSM 901

  Fly   892 VKKEKMLKENQEI------ELE---------VKKKENEQKKI---SSDAKEAKKRMEALEAKYPW 938
            .:.:.|.||:.:.      |||         :||||...|||   .|..:||.::.:.|..|..:
Mouse   902 ERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLF 966

  Fly   939 IPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVLDREEE---NFKETE 1000
            ...|: |    ||..........:|.::.....|:|:|:           :.|:||   .:|...
Mouse   967 RKLEQ-C----NTELKKYSHVNKKALDQFVNFSEQKEKL-----------IKRQEELDRGYKSIM 1015

  Fly  1001 RRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKL----------- 1054
            ...|::.:.|.:..::..|              :|:.|||.:|..|:||.:|.|
Mouse  1016 ELMNVLELRKYEAIQLTFK--------------QVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQ 1066

  Fly  1055 ------------------NPVHTNGCLTGLEIKVGFNGIWKE--SLGELSGGQKSLVALSLVLAM 1099
                              :.|.:....||:.|:|.|.|...|  .:.:|||||||||||:|:.|:
Mouse  1067 SQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAI 1131

  Fly  1100 LKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLFNHANVLFRTLFEEGVS 1164
            .|..|||.|:.||:|.|||..|.:.:..|:.:...::||:..:.:..|...|:..:...|...||
Mouse  1132 QKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGVKFRNKVS 1196

  Fly  1165 ---TITRQVSR 1172
               .||.::::
Mouse  1197 HIDVITAEMAK 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	318/1305 (24%)
		ABC_SMC2_euk	1..>170	CDD:213240	50/168 (30%)
		SMC_hinge	520..637	CDD:214944	33/127 (26%)
		V_Alix_like	690..933	CDD:187408	65/279 (23%)
		P-loop_NTPase	<1073..1167	CDD:304359	35/98 (36%)
Smc3	NP_031816.2	Smc	1..1194	CDD:224117	315/1296 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..269		2/26 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1059..1090		1/30 (3%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119789at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820