DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC2 and AgaP_AGAP011425

DIOPT Version :9

Sequence 1:	NP_610995.1	Gene:	SMC2 / 36653	FlyBaseID:	FBgn0027783	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	XP_554796.1	Gene:	AgaP_AGAP011425 / 1278267	VectorBaseID:	AGAP011425	Length:	1187	Species:	Anopheles gambiae

Alignment Length:	1171	Identity:	630/1171 - (53%)
Similarity:	867/1171 - (74%)	Gaps:	0/1171 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            ||:|.:|:|||||||||||::||||||.|||||||:||||||||||||||||||.:|||::||||
Mosquito     1 MYIKSIVIDGFKSYGRRTEVQGFDPEFNAITGLNGTGKSNILDSICFVLGISNLVHVRATSLQDL 65

  Fly    66 VYKNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDF 130
            |||:|||||||||||::|||:||.|||.|||.|||||:|||:|||||||:|||||.||||:|||.
Mosquito    66 VYKSGQAGITKATVTLIFDNSNPNQCPIGYETCREISITRQIVVGGKNKYLINGKSVQNKRVQDL 130

  Fly   131 FCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRET 195
            |||:||||||||||||||:|.:||||||.|:|||:|||||||.|:.|||:...|||||:.|:.|.
Mosquito   131 FCSVQLNVNNPNFLIMQGRITKVLNMKPAEILSMIEEAAGTSMYEAKRDSALKLIEKKDAKLNEL 195

  Fly   196 KVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIEDRI 260
            ..::.||:.|||.|||:||..|.|:||:||||::|.|:::|.:||:.|:.::..|.....::..|
Mosquito   196 YAVIREEIEPKLEKLRKEREHYIEFQKVCRDIEYLTRLYVSYRYLQLCKGVEESERTIANLQSVI 260

  Fly   261 ANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQGTIQ 325
            ...:.....|.|..:::|...||:|::||.|.||.:..||.||:.:...|||........:.:|.
Mosquito   261 GESEQKIESNCATAQTLEQEAKELQERIDTEGGGVLGELEQQLAVESKKEATVAAERNTMKDSIG 325

  Fly   326 QDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLSTN 390
            |:::|::...|:|.|||:|||.||.:|.:....|::||:|...|.:|:..|||:.||||.|||||
Mosquito   326 QEQRKLKNLQKSIRDDEQALAGKEVEMQRRGESFQALKDACEADEQAFAKAQKRFEAVSAGLSTN 390

  Fly   391 ENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQLV 455
            |:|||:|||:|||.||::.:||.|.||.||:||:|::.:|:.::....::||||::||:...::.
Mosquito   391 EDGEAATLQDQLIAAKQKSAEATTAIKQSEMELKHSQQLLRDKQKNMNSSDAAYLEDKRKLTKVE 455

  Fly   456 VEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDRRKV 520
            .:|..|||:|||..||.|..|.|..||..|....|.|:.||||.||.|::|||:||||.||||.|
Mosquito   456 GQIGQLERELQSTGYEEGSMETLAGRRQALQQEVRGLRSELDRRNAHRWELQYRDPEPGFDRRSV 520

  Fly   521 RGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQRRVTLIPINKIQSGSLN 585
            :|:|.||..|||.:.:.||...|||||||.:||.|.||||:||:|.||.|.|:||:|||....::
Mosquito   521 KGMVAKLVTVKDPKYAQALGTVAGGSLYSVITDTDTTSKKLLQKGQLQTRTTMIPLNKISGRKID 585

  Fly   586 RNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRSVTL 650
            .:|..:|:..||.|||..|:|.|.||...:..|:|.||.:.|.|:|.:|.:|::.|||..|||||
Mosquito   586 PSVARFAEELVGKENVTTALSCISYDPEVDQAMQFAFGHSFIVKNLEIANKITFHPRIKTRSVTL 650

  Fly   651 EGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQALAFNKMKE 715
            :||||||.||:||||..||..||.::..|.:|:...:|.::|:..:..:::.||..|..|.::||
Mosquito   651 DGDVVDPGGTLSGGARAKGNAVLLDVAEINRIQAMLQEKEAELRDISAEVSKIEKTAHRFGQLKE 715

  Fly   716 NLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKLAD 780
            ..|:..:||...:.|||||:|||.:.||||:.::::||::.|:::||.|....||:.|::||:||
Mosquito   716 QHDMLNYELNNLKQRLAQTSFQQTKEEIEELNKKIETLQKTIVEARETQTQCSAKVKDLQAKIAD 780

  Fly   781 AKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNL 845
            .||:|||||.:|..::|.:|:::|:||.||||.||:||||:|||.||||.|.|||:|..::.:.:
Mosquito   781 GKGHRERELKSAEEDLKRSKKKSEESRKNWKKHEQDFETLKLEIEELQKGIVTAKEQAVKLEEQI 845

  Fly   846 EKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKEKMLKENQEIELEVKK 910
            ...:..|..:...:....:.||.|:|.||:.|:|:..|:||::.:..:::|:||:|.|::||:||
Mosquito   846 AALQQRLVEVSGTTDEMTAAVTALKQQIKQHKEKMNSQSKELKAKYHQRDKLLKQNDELKLEIKK 910

  Fly   911 KENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKMQEKKD 975
            ||||..|:.::.|:...|:..:|.|||||||:|..||:|||||||:||||.|||.||.|:|:.||
Mosquito   911 KENEITKVRNENKDGYDRISGMEQKYPWIPEDKEFFGVKNTRYDYNKEDPQEAGRKLKKLQDSKD 975

  Fly   976 KMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATEVNTNFS 1040
            ||.|.:|..|:::|:||||.:||..||:.:|..||:||:.||..:|||::.:|..|.:||:.||.
Mosquito   976 KMSRNVNQKAMVLLEREEEQYKEVMRRKKVVEDDKKKIQAIITDLDEEKKKKLKVAWSEVDENFG 1040

  Fly  1041 GIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGIWKESLGELSGGQKSLVALSLVLAMLKFSPA 1105
            .|||:||||.:|:|.|......:.|||:||||||:|||||.||||||:|||||||:|||||:.||
Mosquito  1041 SIFSTLLPGTQARLVPPDGVDFMKGLEVKVGFNGMWKESLTELSGGQRSLVALSLILAMLKYKPA 1105

  Fly  1106 PLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLFNHANVLFRTLFEEGVSTITRQV 1170
            |||||||||||||:|||||||:|||.|||||||:|||||||:||:|||||||.|.:|:|.:||.|
Mosquito  1106 PLYILDEVDAALDLSHTQNIGNMLKAHFTNSQFIIVSLKDGMFNNANVLFRTKFIDGMSGVTRTV 1170

  Fly  1171 S 1171
            :
Mosquito  1171 N 1171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	627/1166 (54%)
		ABC_SMC2_euk	1..>170	CDD:213240	136/168 (81%)
		SMC_hinge	520..637	CDD:214944	56/116 (48%)
		V_Alix_like	690..933	CDD:187408	98/242 (40%)
		P-loop_NTPase	<1073..1167	CDD:304359	76/93 (82%)
AgaP_AGAP011425	XP_554796.1	Smc	1..1172	CDD:224117	630/1171 (54%)
		ABC_SMC2_euk	1..>156	CDD:213240	125/154 (81%)
		SMC_hinge	519..637	CDD:214944	56/117 (48%)
		Prefoldin	712..850	CDD:238453	65/137 (47%)
		DUF342	<815..911	CDD:302792	37/95 (39%)
		P-loop_NTPase	<1063..1167	CDD:304359	83/103 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	1253	1.000	Domainoid score	I80
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4705
Inparanoid	1	1.050	1266	1.000	Inparanoid score	I536
OMA	1	1.010	-	-		QHG54206
OrthoDB	1	1.010	-	-		D11228at50557
OrthoFinder	1	1.000	-	-		FOG0003760
OrthoInspector	1	1.000	-	-		oto107952
Panther	1	1.100	-	-	LDO	PTHR43941
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3124
TreeFam	1	0.960	-	-
	13	12.940