Protein Alignment SMC2 and AgaP_AGAP007826

DIOPT Version :9

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_317674.2
• Gene: AgaP_AGAP007826 / 1278132
• VectorBaseID: AGAP007826
• Length: 1376
• Species: Anopheles gambiae
• Alignment Length: 1314
• Identity: 316/1314 - (24%)
• Similarity: 554/1314 - (42%)
• Gaps: 285/1314 - (21%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            :.::::....||||.....:..|...|::|.|.|||||||::||:.||.|. ..|.:|:..|..|
Mosquito    70 LIIERITNYNFKSYAGHVMLGPFHQRFSSIIGPNGSGKSNVIDSMLFVFGY-RAQKIRSKKLSVL 133

  Fly    66 VYKNGQAGITKA-TVTIVF------DNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQ 123
            ::.:.:...|.: ||.:.|      ::.:..:.|..     ...|.|.......:.:.|:.|.|.
Mosquito   134 MHNSAKHPNTNSCTVGVHFKQIVDREDGSFDEVPNS-----AFVVARTAFRDNSSYYTIDNKRVH 193

  Fly   124 NKKVQDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKE-------VLSMVEEAAGTSQYKTK---- 177
            .|:|........:::::..|||:||:::.:..||.|.       :|..:|:..||::||..
Mosquito   194 FKEVSKLLKQHGIDLDHNRFLILQGEVESIAMMKSKAQTENDCGLLEYLEDIVGTTRYKVPLLKI 258

  Fly   178 RDATKTLIEKKETKVRETKVLLDEEVLPKLVK--------LRQE----RSAYQEYQKICRDIDFL 230
            .:....|.|::..|....|  |.|..:..|.|        |:||    |:..|:.|
Mosquito   259 NERVDALNEERTEKHNRCK--LAEREMKDLEKPKTEAVEYLKQENTLTRTRNQQIQ--------- 312

  Fly   231 IRIHISAKYLKQCETLKTVEANEHKIE-DRIANCKATHAKNL----AEVESIENSVKEMQQQIDA 290
                   |||  ||..:.:  .|.::| |:.|...|.|.:..    ||....|..|||
Mosquito   313 -------KYL--CEQKRKI--GEFEVERDQAAGILAKHDETYDALKAERVEKEKLVKE------- 359

  Fly   291 EMGGSIKNLETQLSAKRALEATATGSL---KAAQGTIQQDEKKIRMASKNIEDDERALAKKEADM 352
                .||..:..:|||.:.|:|...||   ...|..::...::.:...:.|..:|:.|.:
Mosquito   360 ----EIKQYDELVSAKESKESTLKNSLDKFAKVQANMRATNERRKKTLEQIAAEEKRLLE----- 415

  Fly   353 AKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLSTNE---NGEASTLQEQLIVAKEQFSEAQT 414
                     |::...::.|..|:::.|:|::::..:..|   ....:||:::..|..|:..:.||
Mosquito   416 ---------LQDVPKKNKKEIEESEAKIESLTRQKTEVEAKLTANLATLKDETKVLLEEKEKLQT 471

  Fly   415 TIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKL----HDQLVVEIKNLERQLQSLDYEGGHF 475
            .:    |||:  |.|       .::..|..:.:.:|    ||: |.|    .|:|:||.|.....
Mosquito   472 EL----IELK--RAV-------DESKSALSIAESELKICQHDE-VTE----RRKLESLRYSYEET 518

  Fly   476 EK-LKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDRRKVRGLVGKLFQVKDMQNSMAL 539
            || |:::|..|...:..|.........::..||....|.....:.:|.:.|||      |.|||.
Mosquito   519 EKDLEEKRARLQTLEEALPVTRTELETAKQKLQENANEERELTQTLRAVQGKL------QESMAA 577

  Fly   540 VQ-------------------------------------------TAGGSLYSYVTDDDVTSK-- 559
            :|                                           |..|:|...|.:...|:|
Mosquito   578 MQSTRSQGKVLDALMRQKNEGRIPGILGRLGNLGGIDARYDVAISTCCGTLDHIVVETIDTAKAC 642

  Fly   560 -KILQRGNLQRRVTLIPINKIQSGSLNRNVVEYAQNKVGAENVQWAMSLIDY-DRYYEPVMKFCF 622
             :.|::.:: .|.:.|.:.|||  ...||.....|.   .|||.....||.. |:...|...|..
Mosquito   643 IEFLKQHDI-GRASFIALEKIQ--QYERNCHTQIQT---PENVPRLFDLIRVEDQRVLPAFYFAL 701

  Fly   623 GGTLICKDLIVAKQISYDPRINCRSVTLEGDVVDPHGTVSGG-------------------AAPK 668
            ..||:.::|...::|:|. |...|.||:.|||::..||:|||                   :.|.
Mosquito   702 RDTLVAENLDQGQRIAYG-RQRFRVVTIGGDVIETSGTMSGGGRSQQRGRMGTSVQTKTSASEPA 765

  Fly   669 GANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIEN--QALAFNKMKENLDL-RQH----ELTM 726
            ||:..|    |:|::...:||.::|..:::|...:|.  |.|.....::.::| |.|    .||.
Mosquito   766 GASSRE----IEQMQIRAQEIQTQINYLQEQQGELEATIQRLTAKLKQQEMELKRMHMDVASLTQ 826

  Fly   727 CENRLAQTTFQQNQ--AEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKLADAKGYREREL 789
            ...||.:....|.:  |......|:|:.||.::.:.::...:|..|        |||........
Mosquito   827 QMPRLKEQVDWQAERVARTHSDPEKVRALEAKVAECKQAFDSSSTK--------ADAMQKNVDRY 883

  Fly   790 NAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAELDA 854
            ....|||..:|.:..:::.|...:  :.:.|...|::|...|:|:::..|:..|.:...:.|::|
Mosquito   884 TEQINEITNSKVKVLQTKINGLGK--QIDKLSANISKLTVEIKTSERNVQKSKDKINSMEDEVEA 946

  Fly   855 LKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMR---------NQLVKKEKMLKENQEIELEVKK 910
            .:........|.|:||    |:.:|||::.:||:         :..:|||.:..:.:|.|.::|:
Mosquito   947 AQSAIRKGNDERTQLE----EEANKLREELEEMKLAIEKAHEGSSSIKKEIVALQKREAEGKMKR 1007

  Fly   911 KENEQ--KKISSDAKEAKK-----RMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLA 968
            .|.||  :.|.:..:|.|.     |.:....|...||||.....:|    :|::|:..  ..||.
Mosquito  1008 LEFEQILQTIETKLQETKDTLPHWRDKLKPLKLHEIPEEPPQEPLK----EYTEEELD--SYKLP 1066

  Fly   969 KMQEKKDKMERTLNMNA--IMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQ---DQL 1028
            .:|.:...:|..||.|.  :.|:|       |..::|....|....:::|..|.:|..|   |..
Mosquito  1067 DLQYQISILEEKLNANKPNLSVID-------EFLKKREAYLMRVAVLEEITAKRNEMRQLYDDVR 1124

  Fly  1029 NKAATE-------VNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFN-GI---------- 1075
            .|..||       :......::..:..|.:|:|..|.:..         .|| ||
Mosquito  1125 KKRFTEFMRGFHIITKKLKEMYQMITLGGDAELELVDSMD---------PFNEGIVFSVRPPKKS 1180

  Fly  1076 WKESLGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLI 1140
            || .:..||||:|:|.:|:||.|:..:.|:|||::||:|||||..:...:...:|:...|:||:|
Mosquito  1181 WK-MISNLSGGEKTLSSLALVFALHYYKPSPLYVMDEIDAALDFKNVSIVAHYIKERTKNAQFII 1244

  Fly  1141 VSLKDGLFNHANVL 1154
            :||:..:|..::.|
Mosquito  1245 ISLRSNMFELSDYL 1258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	316/1314 (24%)
		ABC_SMC2_euk	1..>170	CDD:213240	46/182 (25%)
		SMC_hinge	520..637	CDD:214944	35/163 (21%)
		V_Alix_like	690..933	CDD:187408	60/267 (22%)
		P-loop_NTPase	<1073..1167	CDD:304359	35/93 (38%)
AgaP_AGAP007826	XP_317674.2	ABC_SMC4_euk	70..>230	CDD:213241	43/165 (26%)
		Smc	72..1266	CDD:224117	316/1312 (24%)
		SMC_hinge	601..716	CDD:214944	26/120 (22%)
		ABC_SMC4_euk	<1177..1271	CDD:213241	32/83 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810