DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC2 and AgaP_AGAP006388

DIOPT Version :9

Sequence 1:	NP_610995.1	Gene:	SMC2 / 36653	FlyBaseID:	FBgn0027783	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	XP_316422.3	Gene:	AgaP_AGAP006388 / 1277000	VectorBaseID:	AGAP006388	Length:	1201	Species:	Anopheles gambiae

Alignment Length:	1326	Identity:	312/1326 - (23%)
Similarity:	582/1326 - (43%)	Gaps:	289/1326 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            |::|::::.|||||..:|.:|.||.....:.|.|||||||...:|.|||. ....::|....|.|
Mosquito     1 MHIKQVIIQGFKSYREQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLS-DEFTHLRPEQRQAL 64

  Fly    66 VYKNGQAGITKATVTIVFDNTN---PAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKV 127
            :::........|.|.|:|||::   |..        :|....|:|:...|:::.:|.|:|...:|
Mosquito    65 LHEGTGPRAMSAYVEIIFDNSDNRVPID--------KEEIYLRRVIGAKKDQYFLNKKVVPRSEV 121

  Fly   128 QDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKV 192
            .:...|...:.:||.:::.||||.|:........|.::.|.|||..|..:::.:..|:.:.|.|:
Mosquito   122 VNLLESAGFSNSNPYYIVKQGKINQMATAPDSHRLKLLREVAGTRVYDERKEESMNLLRESEGKL 186

  Fly   193 RETKVLLD--EEVLPKLVKLRQERSAYQEYQKICRDIDFLI---RIHISAKYLKQCETLKTVEAN 252
            .:....|.  |:.|..|.:.::|.|.||::.|..|.::::|   .:..:.|.|::.:..:....:
Mosquito   187 EKISEYLRTIEDRLKTLEEEKEELSEYQKWDKARRTLEYVIYETELKETRKQLEELDGQRKSSGD 251

  Fly   253 E--------HKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQ--LSAKR 307
            :        .|.:||:.|.:          ::::::.|::   :.|:...|:...|.|  |..|.
Mosquito   252 KQLLLTQEIQKAQDRLKNAQ----------KALKDAKKDV---VTAKDEKSVLATEHQQLLREKT 303

  Fly   308 ALEATATGSLKAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLK---EADARD 369
            .|:.|.:......||    |.|....|.:.:|..:..:|:||.::.:|:..:|:::   |..:|:
Mosquito   304 KLDLTISDLSDEVQG----DNKSKERAEQELERLKITIAEKEKELEQVRPRYEAMRRKEEECSRE 364

  Fly   370 SKAYEDAQKKLEAVSQG----LSTNE------NGEASTLQEQLIVAKEQFS---EAQTTIKTSEI 421
            ....|..:|:|.| .||    .|:.|      .||..:|.:|:   |::.|   :.|..:|
Mosquito   365 LNLKEQKRKELYA-KQGRGSQFSSKEERDKWIQGELKSLNKQI---KDKISHQNKLQDDLK---- 421

  Fly   422 ELRHTRGVLKQREGETQTNDAAYVKDKKLHDQLVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLH 486
                 :.:.||.|.|.:..:     ..:..:||.|:|....:....|..:..|::.|   |||:.
Mosquito   422 -----KDIAKQGELEKKIQE-----HTESFEQLRVQIDEHNKNFYELKKKKDHYQSL---RNDIW 473

  Fly   487 MRKRDL-------KRELDRCNASRYDLQYQDPEPNFD-RRKVRGLVGKLFQ----VKDMQNS--- 536
            .::..:       |.||.|.:.:   |:....:|..: |..||.::....|    ..|:.|:
Mosquito   474 KKETAVTQTLSGYKEELARADQA---LRSMAGKPILNGRDSVRKVLESFLQRGREYADIANAYYG 535

  Fly   537 -------------MALVQTAGGSLYSYVTDDDVTSKKILQRGNLQR---RVTLIPINKIQSGSLN 585
                         .|:..|||..|:.::.:.|....:||:..|.|:   .||.:|:|::|.
Mosquito   536 PVIENFNCDKSIYTAVEVTAGNRLFHHIVESDRVGTQILKEMNKQKLPGEVTFMPLNRLQV---- 596

  Fly   586 RNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRSVTL 650
             .:.:|.::......:    |.:.|:..|:..:::.||.||||::|..|.:::....::|  |||
Mosquito   597 -KIHDYPEDPDSIPMI----SKLKYEEQYDKALRYIFGKTLICRNLERATELAKSTGLDC--VTL 654

  Fly   651 EGDVVDPHGTVSGGAAPKGANVL-------EELHAIKQIEKEYREIDSEIAQVEKQIASIENQAL 708
            |||.|...|:::||......:.|       |....|::.|||..:..:|:.|.|..|.||.::..
Mosquito   655 EGDQVSSKGSLTGGYFNTSRSRLEMQKKRSEYSQLIQEHEKELADFRAELKQTEANINSIVSEMQ 719

  Fly   709 -----------AFNKMKENLDLRQHELTMCENRLA--QTTFQQNQAEIEEMRERVKTLEQQIIDS 760
                       ||.|::.::.|.:.||:..|...:  :.:..|.:|.:|.|....:.||.::
Mosquito   720 KTETKQGKSKDAFEKIQADIRLMKDELSRIERFRSPKERSLAQCKANLEAMTSTKEGLENEL--- 781

  Fly   761 REKQKTSQAKIVDIEAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEIT 825
             .::..||..:.|            :.|:::..:||:         |.|.:.:|.....:.||:|
Mosquito   782 -HQELMSQLSVQD------------QHEVDSLNDEIR---------RLNQENKEAFTSRMSLEVT 824

  Fly   826 ELQKSIETAKKQHQEMIDNLEKFKAEL-DALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRN 889
            :        .|....:.:||.:.|.|| .||:             |.:::::|.:|.:    .||
Mosquito   825 K--------NKLENLLTNNLFRRKDELVQALQ-------------EISVEDRKRQLTN----CRN 864

  Fly   890 QLVKKEKMLK----ENQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKN 950
            ::|..||.:|    :.:|::          :|:|...|:.|...:.||:   ||.:||.
Mosquito   865 EVVATEKRIKKVLTDTEEVD----------RKLSEALKQQKTLQKELES---WIQKEKE------ 910

  Fly   951 TRYDYSKEDPHEAGNKLAKMQEKKDKM--------ERTLNMNAIMVLDREEEN------FKETER 1001
                 ::|...|.|.::.|...|::.:        |:...:.|:..:|...:.      |||.|:
Mosquito   911 -----AQEKLEEDGKRMEKWATKENMLRQKIDECTEKIAGLGALPNVDASYQKMSLKSLFKELEK 970

  Fly  1002 RR---------NIVAMD----------------------KEKIKKIIVKMDEEEQDQLNKAATEV 1035
            ..         |..|:|                      |:||.:::..::..:.:.:.....:|
Mosquito   971 ANQHLKKYNHVNKKALDQFLSFSEQKEKLYKRKAELDVGKDKICELMQLLEARKVEAIQFTFRQV 1035

  Fly  1036 NTNFSGIFSSLLPGAEAKL--------------NPVHTNGCLTGLEIKVGFNGIWKE--SLGELS 1084
            ..|||.:|..|:|.....|              ..|.|:...||:.|:|.|..:..|  .:.:||
Mosquito  1036 AANFSEVFKKLVPQGNGHLILRTTNDQEGNDMEREVETSDEFTGIGIRVSFTQVDAEMREMNQLS 1100

  Fly  1085 GGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLFN 1149
            |||||||||:|:.|:.|..|||.|:.||:|.|||..|...:..|:.:....:||:..:.:..|..
Mosquito  1101 GGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRSAVADMIHEQSDRAQFITTTFRPELME 1165

  Fly  1150 HANVLFRTLFEEGVS---TITRQVSR 1172
            .|:..:...|...||   .:|::|:|
Mosquito  1166 KAHKFYGVRFRNKVSHVDCVTKEVAR 1191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	309/1320 (23%)
		ABC_SMC2_euk	1..>170	CDD:213240	51/171 (30%)
		SMC_hinge	520..637	CDD:214944	32/139 (23%)
		V_Alix_like	690..933	CDD:187408	53/260 (20%)
		P-loop_NTPase	<1073..1167	CDD:304359	34/98 (35%)
AgaP_AGAP006388	XP_316422.3	SMC_N	2..1181	CDD:280601	307/1313 (23%)
		ABC_SMC3_euk	3..>150	CDD:213239	48/155 (31%)
		SMC_hinge	533..643	CDD:214944	27/118 (23%)
		P-loop_NTPase	<1087..1183	CDD:304359	34/95 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119789at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820