Protein Alignment SMC2 and SMC1

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_311953.3
• Gene: SMC1 / 1273015
• VectorBaseID: AGAMI1_004144
• Length: 1244
• Species: Anopheles gambiae
• Alignment Length: 1307
• Identity: 300/1307 - (22%)
• Similarity: 563/1307 - (43%)
• Gaps: 255/1307 - (19%)

  Fly     2 YVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLV 66
            :::.:.::.||||..||.| |....|:|:.|.|||||||.:|:|.||:| ....::|...|.:|:
Mosquito     9 FLQCIEVENFKSYRGRTTI-GPLKRFSAVIGPNGSGKSNFMDAISFVMG-EKTSSLRVRKLTELI 71

  Fly    67 YKNGQAGI-----TKATVTIVFDNTNPAQCPQGYEKCREISVT-RQVVVGGKNKFLINGKLVQNK 125
              || |.|     .:|:|...|.....|:        .|:..| ::.|:...:::.|||.:|..:
Mosquito    72 --NG-ASIGRPISNRASVMARFIIKTEAE--------GEVEKTFQRSVINASSEYRINGSVVSPQ 125

  Fly   126 KVQDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTS-----------QYKTKRD 179
            ........|.:||...|||:.||.::.:.....||..::.||.:|:.           :.:...:
Mosquito   126 HYLAELEKIGINVKAKNFLVFQGAVETIAIKNAKERTALFEEISGSGLLKEDYNRLKHEMQMAEE 190

  Fly   180 ATKTLIEKKETKVRETK-VLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQC 243
            .|:...:||.....|.| ..|:::...:...|:||.|..|.:.::.:    |......||.||:.
Mosquito   191 ETQFTYQKKRGIAAERKEARLEKQEADRYASLKQECSEKQVHFQLFK----LYHNEKEAKRLKED 251

  Fly   244 ETLKTVEANEHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRA 308
            :..|..|.|  .||.|.........:...||..:...:.:.:|:        |:.:|.::|.:..
Mosquito   252 QISKQQELN--IIEKRKEEADEVLKEKKKEVGKMTREMAKKEQE--------IREVEAEMSKRHP 306

  Fly   309 LEATATGSLKAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAY 373
            :      .:||.: .:...:||:..|.|.:|...||....:||:.|:..|   |:|.:.:.: |:
Mosquito   307 M------FIKAKE-KVAHTQKKLDGALKTLEQARRADEAHQADIKKLVDE---LQEVEVKRA-AF 360

  Fly   374 EDAQKKLEAVSQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREG--- 435
            |:     |...:   :.:.|....|:..|:...::..  |....||...|.|...|.::::.
Mosquito   361 EN-----EVAGE---SKKRGSNVHLERDLVQEYDRLK--QKADATSSKYLIHLDSVNREQKSDQD 415

  Fly   436 --ETQTNDAAYVKD--KKLHDQLVVEIKN--LERQLQSLDYEGGHFEKLKQRRNDLHMRKR---- 490
              :::.|..|.:::  ||:..:     ||  |:||.:.:|:       :|..|..|..:||
Mosquito   416 RLDSEINKKAQIEENYKKIESE-----KNEALKRQEKLIDH-------IKTSRLGLEEQKRIKAE 468

  Fly   491 -------------DLKRELDRCNASRYDLQYQDPEPNFDRRKVRGLVGKLFQVK----------- 531
                         :|:.|||.......|.:....|.  .|||.:..|.:||:::
Mosquito   469 LSQDVGTSKERIHELQSELDNVREQLGDAKIDKHED--ARRKKKQEVVELFKLEVPGVYDRMINM 531

  Fly   532 ----DMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQRRV----TLIPINKIQSGSLN--- 585
                ..:.::|:.:..|..:.:.:.|.:.|:::.:|  .|:.::    |.:|::.:|...|.
Mosquito   532 CQPTHKRYNVAVTKVLGKYMEAIIVDTEKTARRCIQ--ILKEKMLDVETFLPLDYLQKKPLKERL 594

  Fly   586 RNVVEYAQNKVGAENVQWAMSLIDYD-RYYEPVMKFCFGGTLICKDLIVAKQISYD-PRINCRSV 648
            ||:.|       ..||:....::.:. ...||.:.|.....|:|:....|.:::|: .|....::
Mosquito   595 RNIEE-------PRNVKLIYDVLKFSPPEIEPAVLFATNNALVCETPDDAMKVAYEIDRSRYDAL 652

  Fly   649 TLEGDVVDPHGTVSGGA--APKGANVLEELHAI------KQIEKEYREI------DSEIAQVEKQ 699
            .|:|......|.:|||:  ..:.|...:|.|..      ::|.:|.:|:      ..|:..||.|
Mosquito   653 ALDGTFYQKSGIISGGSHDLARKAKRWDEKHMAQLKLQKEKITEELKEVMKKTRRQGELTTVESQ 717

  Fly   700 IASIENQALAFNKMKENLDLRQHELTMCENRLAQTTFQQNQ--AEIEEMRERVKTLEQQIIDSRE 762
            |..:||: |.::  ..:|:..:..:...:.:|...|.:.:|  .:|.|:..|::..:.:|.|.:|
Mosquito   718 IRGLENR-LKYS--MNDLETSKKNINEYDRQLEDFTRELDQIGPKISEIERRMQQRDMKIQDIKE 779

  Fly   763 KQKTSQAKIVDIEAK------LADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQ 821
            .....:.   |:.|:      :|:.:.:.||||        |.:|...|.||.:   ||:.:.:.
Mosquito   780 SMNNVED---DVYAEFCARIGVANIRQFEEREL--------VLQQERAKKRAEF---EQQIDRIN 830

  Fly   822 LEITELQKSIETAK------KQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKL 880
            ..: |.::|.:|:|      :..|:..|:||.||          .:.|.:..|:|:  .::|.:|
Mosquito   831 NNL-EFERSKDTSKNVQRWERAVQDDEDSLETFK----------QAEARQRQEIEK--DKEKIEL 882

  Fly   881 RDQNKEMRNQLV--KKEKMLKENQEIELEVKKKENEQKKISS-----DAKEAKKRMEALEAK--- 935
            ..|.|.....||  .:|:|.|..:|::...|:.....:.|::     ::.::|::...::||
Mosquito   883 MKQEKAAHKTLVDQMEEEMAKARREVQALAKELAAIHQSIANIESRIESMKSKRQTILMQAKMES 947

  Fly   936 --YPWIPEEKNCFGMK-----------------------------NTRYDYSKEDPH-------- 961
              .|.:....:..|.:                             ....||||.:.|
Mosquito   948 IEIPLLQGSMDDIGQQQQGQGGGQGAGGQGGEYAADGGSAYERESRIEIDYSKLEHHLKNLSDPD 1012

  Fly   962 ---EAGNKLAK-MQEKKDKMER--TLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKM 1020
               ::|:.||| :|.|.|.:|:  |.||.|:..|||..|..:.|...........:|.|....|:
Mosquito  1013 QIKKSGDSLAKELQSKLDTLEKIQTPNMKAMQKLDRVTEKIQSTNEEFEAARKKAKKAKAAFEKV 1077

  Fly  1021 DEEEQDQLNKAATEVNTNFSGIFSSLL--PGAEAKLNPVH-TNGCLTGLEIKVGFNGIWKESLGE 1082
            ..|...........::.....|:..|.  ..|:|.|.|.: ....|.|:.......|...:.:..
Mosquito  1078 KNERCTLFTNCCNHISDAIDAIYKQLSRNEAAQAYLGPDNPEEPYLDGINYNCVAPGKRFQPMSN 1142

  Fly  1083 LSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGL 1147
            ||||:|::.||:|:.|:..|.|||.::|||:|||||.::...:.|.:::..||.|.:::|||:..
Mosquito  1143 LSGGEKTIAALALLFAIHSFQPAPFFVLDEIDAALDNTNIGKVASYIREKTTNLQTIVISLKEEF 1207

  Fly  1148 FNHANVL 1154
            :.||:||
Mosquito  1208 YCHADVL 1214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	300/1307 (23%)
SMC1	XP_311953.3	SMC_N	9..1217	CDD:481474	300/1307 (23%)