Protein Alignment SMC2 and AgaP_AGAP002985

DIOPT Version :9

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_311902.4
• Gene: AgaP_AGAP002985 / 1272971
• VectorBaseID: AGAP002985
• Length: 1082
• Species: Anopheles gambiae
• Alignment Length: 1241
• Identity: 245/1241 - (19%)
• Similarity: 450/1241 - (36%)
• Gaps: 362/1241 - (29%)

  Fly     3 VKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVY 67
            |.|:||..|..: |...:| |:.....:.|.||||||.||.::...||.:..|..|.|:|:||:
Mosquito    50 VLKIVLKNFMCH-RHMVVE-FNKRANLLVGKNGSGKSAILAAMTIGLGCNAGQTNRCSSLKDLI- 111

  Fly    68 KNGQAGITKATVTIVFDNTN-PAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDFF 131
            |:|:   |:|.:.|..:||. .|..|:.|              ||:                 ..
Mosquito   112 KHGE---TQAVIEIHLENTAFNAYDPERY--------------GGR-----------------II 142

  Fly   132 CSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRETK 196
            |...||                              |:|...||.|.:..:|:   ..::....|
Mosquito   143 CERTLN------------------------------ASGGGSYKLKNEHGQTV---STSRAELQK 174

  Fly   197 VL-------------LDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKT 248
            :|             |::::...|:|...|...|..:.|                 ..|.:|:|
Mosquito   175 ILLAFNIQVDNPICVLNQDLARSLLKDSDESKQYTFFSK-----------------ATQIDTIK- 221

  Fly   249 VEANEHKIEDRIANCKATHAKNLAEV--------ESIENSVKEMQQ-QIDAEMGGSIKNLETQLS 304
                     .::..| |..||...:|        |.:.|.:..::: |.:.|..|.:..|.::|.
Mosquito   222 ---------QKLNEC-AVIAKKARDVLVVKEKSLEYLSNEIVVLEEKQSNLESAGRMGELLSELQ 276

  Fly   305 AKRALE---------ATATGSLKAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFE 360
            ||.|..         |.....||..:.:|::.|.:||.....:...:..:....||:...:.|:.
Mosquito   277 AKLAWRNVIDQEEQLAAVDDELKKLRTSIEEQEHRIRNREALVAKTDSTIDTYRADIESKKQEYV 341

  Fly   361 SLKEADARDSKAYEDAQKKLEAVSQGLS------TNENGEA----STLQEQLIVAKEQFSEAQTT 415
            :||||.....:..:|.|.|..|:.:|:.      |....:|    ..|||:......|..:.:..
Mosquito   342 ALKEAYGTVRRTLQDVQAKQAAIERGMRNASERVTRIQKDARQIEQDLQERNRDGLSQVEQRKQA 406

  Fly   416 IKTSEIELRHTRGVL------KQREGETQTNDAAYVKD---KKLHDQLV--VEIKNLERQLQ--- 466
            ::|.:.:|:.....|      .|||.:...|..|:|||   :|.|::..  .|...:|:||:
Mosquito   407 VETEKAQLKERNDELASMIASAQREVDLMYNTMAHVKDAREEKHHERCAKQSETTRIEKQLEQFE 471

  Fly   467 -----SLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDRRKVRGLVGK 526
                 .|...|.:...|..|...||.:.                 |:.:        ..||.:|:
Mosquito   472 SAPRSKLAVYGTNMPALVARIRQLHQQG-----------------QFSE--------MPRGPLGQ 511

  Fly   527 LFQVKDMQNSMALVQTA-GGSLYSY---VTDDDVTSKKILQR--GNLQRRVTLIPINKIQSGSLN 585
            ..:|::.:.| .:|:|| ||.|.::   ..:|..|...:|:|  .:||.|.       |.:|
Mosquito   512 YIEVRNKKWS-GIVETALGGCLSAFFVSTQEDWRTLDALLKREFPDLQNRT-------IFTG--- 565

  Fly   586 RNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCR---S 647
            |.|.|....:.|....|                    .||.:..:||...    ||.:..|   |
Mosquito   566 RFVKELYDVRSGCVQEQ--------------------DGTHLLMNLIKVN----DPVVMNRLIDS 606

  Fly   648 VTLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASI---ENQALA 709
            ..::..:|..|.:|                ||        ::.|||..|.:.::.:   |..|..
Mosquito   607 AAIDTILVTEHQSV----------------AI--------QLTSEIENVPQNLSKVIVAEPCAEF 647

  Fly   710 FNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDI 774
            |.:.|    .|.:.|.....|..|.:..:.:...::.||:::         ||..
Mosquito   648 FPQPK----YRSYGLQQKPPRYLQVSMDELKRHTQQRREQLQ---------RELN---------- 689

  Fly   775 EAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETL-------QLEITELQKSIE 832
              :|..|....:..|...|.::...:|..:|.:......||:.:.|       :.|.|.|::.:|
Mosquito   690 --ELNSAYAKEDERLQEMTRKLHQRQQHMKKLQQELLTNEQQLQQLAGVVFEGETEETTLREELE 752

  Fly   833 TAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKEKM 897
            .::....::...:|:.:|:||.::       ..|.:.||..:.:||.:.....|:.......:|.
Mosquito   753 HSRTILAKLQKGIEEEQAKLDQVR-------RTVQQEEQTAQAKKDAMGAVEAEIARIQASIDKE 810

  Fly   898 LKENQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHE 962
            .:...:::...|.|:...|:.:...:|.|:...||.|            .::..|
Mosquito   811 QQARHDLQTNHKVKQQALKRSTESMEERKRTRVALSA------------ALEQAR---------- 853

  Fly   963 AGNKLAKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMD--EEEQ 1025
                    ||..:|.||......|..:::.:.....||:|..:|:..::|::.::.:::  ..|:
Mosquito   854 --------QEASEKGERPDESEQIPSVEQLKGKIHTTEKRIRLVSATQDKLEDVVEELEGKNRER 910

  Fly  1026 DQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGIW--KESLGE------ 1082
            |:|.:.:|.:. :.:.:...:.....:.|:.:.|:   ..|.:|..|..|.  :..||:
Mosquito   911 DELIRYSTALR-DLTQMMRDIRKSRFSHLHKLTTH---MALRVKHKFTNIMQIRNYLGKLRVNQE 971

  Fly  1083 ------------------------LSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQ 1123
                                    ||||::|...::.::|:......|.:.|||.|...|..:..
Mosquito   972 ECRLSLSVVPRDANVQNAVSTTKSLSGGERSYATVAFLIALWSCVSTPFFFLDEYDVFTDQVNRH 1036

  Fly  1124 NIGSML 1129
            .|..:|
Mosquito  1037 TITRLL 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	245/1241 (20%)
		ABC_SMC2_euk	1..>170	CDD:213240	41/167 (25%)
		SMC_hinge	520..637	CDD:214944	29/122 (24%)
		V_Alix_like	690..933	CDD:187408	46/252 (18%)
		P-loop_NTPase	<1073..1167	CDD:304359	17/89 (19%)
AgaP_AGAP002985	XP_311902.4	ABC_SMC6_euk	50..>206	CDD:213243	52/225 (23%)
		Smc	52..1062	CDD:224117	244/1239 (20%)
		SMC_hinge	506..614	CDD:214944	33/142 (23%)
		ABC_SMC6_euk	<969..1081	CDD:213243	14/74 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810