DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC2 and SMC4

DIOPT Version :9

Sequence 1:	NP_610995.1	Gene:	SMC2 / 36653	FlyBaseID:	FBgn0027783	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_001002800.1	Gene:	SMC4 / 10051	HGNCID:	14013	Length:	1288	Species:	Homo sapiens

Alignment Length:	1294	Identity:	286/1294 - (22%)
Similarity:	549/1294 - (42%)	Gaps:	222/1294 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            :.:..:|...||||.....:..|...|:.|.|.|||||||::||:.||.|. ..|.:|:..|..|
Human    82 LMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGY-RAQKIRSKKLSVL 145

  Fly    66 VYKNGQ-AGITKATVTIVFDNTNPAQCPQGYEKC--REISVTRQVVVGGKNKFLINGKLVQNKKV 127
            ::.:.: ..|...||.:.|......: ...||..  ....|:|.......:.:.|:||....|.|
Human   146 IHNSDEHKDIQSCTVEVHFQKIIDKE-GDDYEVIPNSNFYVSRTACRDNTSVYHISGKKKTFKDV 209

  Fly   128 QDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKV 192
            .:...|..:::::..|||:||:::|:..||||   ...|...|..:|.........|.|..:...
Human   210 GNLLRSHGIDLDHNRFLILQGEVEQIAMMKPK---GQTEHDEGMLEYLEDIIGCGRLNEPIKVLC 271

  Fly   193 RETKVLLDE--EVLPKLVKLRQERSAYQEYQKICRDIDFLI--------RIHISAKYLKQCE-TL 246
            |..::|.:.  |.|.::..:.:|:.|.:..:.|.  |:||.        :.|:...|:.:.: .:
Human   272 RRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIA--IEFLTLENEIFRKKNHVCQYYIYELQKRI 334

  Fly   247 KTVEANEHKIED--RIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLE--TQLSAK- 306
            ..:|..:.||.:  :..|.|:....|  |:::....||:.:::::.......:|.|  |||..:
Human   335 AEMETQKEKIHEDTKEINEKSNILSN--EMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLED 397

  Fly   307 ---RALEATATGSLKAAQGTIQQDEKKIR------MASKNIEDD----ERALAK-KEADMAKVQG 357
               |.....||...|..:..:|:|::|:.      ..|.||.::    ..||.| ||.:..|::.
Human   398 VQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKE 462

  Fly   358 EFESL--------KEADARD------SKAYEDAQKKLEAVSQGLS---TNENGEASTLQEQLIVA 405
            ..:||        ||.::|:      ||:..:|:.|::.....|.   :..|    |...||..|
Human   463 VMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHN----TAVSQLTKA 523

  Fly   406 KEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQLVVEIKNLERQLQSLDY 470
            ||....|..|:|..:..:|...|.|.|.|                     .|:|..|::||.|..
Human   524 KEALIAASETLKERKAAIRDIEGKLPQTE---------------------QELKEKEKELQKLTQ 567

  Fly   471 EGGHFEKLKQRRNDLHMRKRDLKREL--DRCNASRYDLQYQDPEPNFDRRKVRGLVGKLFQVK-- 531
            |..:|:.|.   :||..:..:.|..|  :|......|...|:.:..    ::.|:.|:|..:.
Human   568 EETNFKSLV---HDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSG----RIPGIYGRLGDLGAI 625

  Fly   532 DMQNSMALVQTAGGSLYSYVTDDDVTSK--KILQRGNLQRRVTLIPINKIQSGSLNRNVVEYAQN 594
            |.:..:|:........|..|...|:..:  ..|:|.|: ...|.|.::|:...:.....::..:|
Human   626 DEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNI-GVATFIGLDKMAVWAKKMTEIQTPEN 689

  Fly   595 --------KVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRSVTLE 651
                    ||..|.::.|        :|     |....||:..:|..|.:::|......|.|||:
Human   690 TPRLFDLVKVKDEKIRQA--------FY-----FALRDTLVADNLDQATRVAYQKDRRWRVVTLQ 741

  Fly   652 GDVVDPHGTVSGGAAP-----KGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQALAFN 711
            |.:::..||::||.:.     .|::::.|:.            :.|:.::|.|:.:...:|:...
Human   742 GQIIEQSGTMTGGGSKVMKGRMGSSLVIEIS------------EEEVNKMESQLQNDSKKAMQIQ 794

  Fly   712 KMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRE-------RVKTLEQQII---DSREKQKT 766
            :.|..|:.|..:|...|..: :.|.::..|.|:.:.|       :||.||..::   ..::|||.
Human   795 EQKVQLEERVVKLRHSEREM-RNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKL 858

  Fly   767 SQAKIVDIEAK---LADAKGYRERELNAATN---EIKVTKQRAEKSRANWKKREQEFETLQLEIT 825
            .:..:...:.:   :|:..|..|.|:....|   ||...|.:|::.:.:  |..::.:.....||
Human   859 LEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLD--KINKQLDECASAIT 921

  Fly   826 ELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQ 890
            :.|.:|:||.:..|:..|::.:.:.|:       .....||.:|...:|..:||..:..|.....
Human   922 KAQVAIKTADRNLQKAQDSVLRTEKEI-------KDTEKEVDDLTAELKSLEDKAAEVVKNTNAA 979

  Fly   891 LVKKEKMLKENQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDY 955
            .....::.||::.:..|:|..:..:..:..||...|.::|.::..   |.|.       |::..|
Human   980 EESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGH---IAEH-------NSKIKY 1034

  Fly   956 ------------------------SKED------PHEAGNKLAKMQEKKDKMERTLNMNAIMVLD 990
                                    |.||      |....|::|.::.:..:|:.  |:.||....
Human  1035 WHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKP--NLGAIAEYK 1097

  Fly   991 REEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKLN 1055
            ::||.:.:.....:.:..:::..::....:.::..::.......:.......:..|..|.:|:|.
Human  1098 KKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELE 1162

  Fly  1056 PVHTNGCLTGLEIKVGFN-----GIWKESLGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDA 1115
            .|.:   |......:.|:     ..||: :..||||:|:|.:|:||.|:..:.|.|||.:||:||
Human  1163 LVDS---LDPFSEGIMFSVRPPKKSWKK-IFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDA 1223

  Fly  1116 ALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLFNHANVL---FRTLFEEGVSTITRQVS 1171
            |||..:...:...:.:...|:||:|:||::.:|..::.|   ::|.      .||:.|:
Human  1224 ALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTY------NITKSVA 1276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	284/1289 (22%)
		ABC_SMC2_euk	1..>170	CDD:213240	50/171 (29%)
		SMC_hinge	520..637	CDD:214944	25/128 (20%)
		V_Alix_like	690..933	CDD:187408	54/258 (21%)
		P-loop_NTPase	<1073..1167	CDD:304359	32/101 (32%)
SMC4	NP_001002800.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		ABC_SMC4_euk	82..>241	CDD:213241	47/160 (29%)
		SMC_N	83..1274	CDD:280601	285/1289 (22%)
		DUF4349	<327..427	CDD:305044	21/101 (21%)
		SMC_hinge	613..727	CDD:214944	25/127 (20%)
		ABC_SMC4_euk	<1181..1275	CDD:213241	34/100 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810