Protein Alignment SMC2 and smc2

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_002936738.3
• Gene: smc2 / 100486893
• XenbaseID: XB-GENE-5826169
• Length: 1202
• Species: Xenopus tropicalis
• Alignment Length: 1190
• Identity: 504/1190 - (42%)
• Similarity: 784/1190 - (65%)
• Gaps: 32/1190 - (2%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            |:||.:::||||||.:||||.||||.|.|||||||||||||||||||:||||||..||||.||||
 Frog     1 MHVKSIIIDGFKSYAQRTEINGFDPLFNAITGLNGSGKSNILDSICFLLGISNLTQVRASNLQDL 65

  Fly    66 VYKNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDF 130
            ||||||||||||||:|.|||.:..|.|.|:|...||:||||||:||:||:||||....|.:|||.
 Frog    66 VYKNGQAGITKATVSITFDNYDKKQSPLGFEAHDEITVTRQVVIGGRNKYLINGVNANNTRVQDL 130

  Fly   131 FCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRET 195
            |||:.||||||:||||||:|.:||||||.|:|:|:||||||..|:.|:.|.:..|||||.|::|.
 Frog   131 FCSVGLNVNNPHFLIMQGRITKVLNMKPPEILAMIEEAAGTRMYECKKIAAQKTIEKKEAKLKEI 195

  Fly   196 KVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHK-IEDR 259
            :.:|:||:.|.:.||::|||:|.|||||.|:|:.|.|::|:.:::...|| |...|.|.| ::|.
 Frog   196 QTILEEEITPTIHKLKEERSSYLEYQKIMREIEHLSRLYIAYQFVCAEET-KVRSAEELKEMQDS 259

  Fly   260 IANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQGTI 324
            |...:.|.|:|..:|:.:...:.|:::..|.|:||::::||..|:..:..:.....:|...:..:
 Frog   260 ILKLQDTMAENERKVKELGKEIAELEKLRDQEVGGALRSLEEALAEAQRSDTKVQSALDLKKQNM 324

  Fly   325 QQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLST 389
            :.:|||.:...|::|:|.:||..||.::.|:.....||:|...:|::|...||:...|||.|||:
 Frog   325 KAEEKKRKELVKSMEEDAKALTAKEKEVKKITDSLSSLQETSQKDAEALTGAQQHFNAVSAGLSS 389

  Fly   390 NENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQL 454
            ||:||.:||..|::..|.:.|:|:|..|.::::|:|.:..||.::.|.:..|:.|.||.:..:.:
 Frog   390 NEDGEEATLAGQMMACKNEISKAETEAKQAQMKLKHAQQELKTKQAEVKKMDSGYKKDNEAFEAV 454

  Fly   455 VVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDL---------QYQD 510
            ....:.||.:::.|:||.|..|:|.::|       |.|.|:::|...:...|         :|:|
 Frog   455 KKSKEKLEVEMKKLNYEDGREEQLLEKR-------RGLSRDVNRLREAYESLMARFPNLQFEYKD 512

  Fly   511 PEPNFDRRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQRRVTLIP 575
            ||.|:|..:|:|||..|..|||:..:.||...|||.||:.|.|.:||.||:|::|.|:||.|:||
 Frog   513 PEKNWDSSRVKGLVASLISVKDVSTATALEVVAGGRLYNVVVDTEVTGKKLLEKGELKRRFTIIP 577

  Fly   576 INKIQSGSLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYD 640
            :|||.:..|.::.|..|:|.|||:||..|:||:.|:...:..|::.||.||:|..:..||::::|
 Frog   578 LNKISARCLGKDTVNVAKNLVGADNVHLALSLVGYESELQKAMEYVFGTTLVCDTMDNAKKVTFD 642

  Fly   641 PRINCRSVTLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIEN 705
            .:|..::|||.||..||.||:||||..:.|:||.:|..:|.:::|.|..::::.:|||::.|::|
 Frog   643 RKIMTKTVTLGGDTFDPQGTLSGGARSQNASVLAKLQELKHVQEELRAKETQLQEVEKELMSLKN 707

  Fly   706 QALAFNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAK 770
            ....:.::|:..:::..|..:.:.:|.|:::.:.|.|::.:::.::..|:.:..::|.|..::.|
 Frog   708 TVERYRQLKQQWEMKSEEADLLQTKLQQSSYHKQQEELDTLKQTIEGSEETLKKTKEVQMKAEEK 772

  Fly   771 IVDIEAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQKSIETAK 835
            ...:|.|:.:|:..|||||..|..::...|::|:.|....|:::||.:...||:.||::. :|..
 Frog   773 FKVLEHKMKNAEAERERELKEAQQKLDGAKKKADASNKKMKEKQQEVDAFVLELEELKRE-QTTY 836

  Fly   836 KQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQ-------NKEMRNQLVK 893
            ||..|::|...|      |.:..:.:.||||.:.::::|:.:::|..|       :||::.:..:
 Frog   837 KQQIEVVDEAMK------AYQEQADNMASEVAKNKESVKKAQEELAKQKEIIMGHDKEIKTKSAE 895

  Fly   894 KEKMLKENQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKE 958
            ..|:.:.|.:::|::|:.|:...|...|:.:|..::..:...|.||..||:.||..||.||:...
 Frog   896 AGKLRENNNDLQLKIKELEHNISKHKKDSADAAAKVAKMLNDYEWIASEKHLFGQANTAYDFKTN 960

  Fly   959 DPHEAGNKLAKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEE 1023
            :|.|||.:|.|:||||:|:.|.:||.|:.:|.:.||.:.:..:::.||..||.||...|.::|::
 Frog   961 NPKEAGQRLQKLQEKKEKLGRNVNMRAMNMLTQAEERYNDLMKKKRIVENDKSKILTTIEELDQK 1025

  Fly  1024 EQDQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGIWKESLGELSGGQK 1088
            :.:.||.|..:||.:|..|||:|||||.|.|.|......|.|||.||.....|||:|.||||||:
 Frog  1026 KNEALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQSVLDGLEFKVALGNTWKENLTELSGGQR 1090

  Fly  1089 SLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLFNHANV 1153
            |||||||:||||.|.|||:|||||||||||:|||||||.||:.||.:|||::||||||:||:|||
 Frog  1091 SLVALSLILAMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFRHSQFIVVSLKDGMFNNANV 1155

  Fly  1154 LFRTLFEEGVSTITRQVSRQ 1173
            ||:|.|.:||||:.|....|
 Frog  1156 LFKTKFVDGVSTVARFAQNQ 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	497/1176 (42%)
smc2	XP_002936738.3	SMC_N	2..1167	CDD:426784	499/1179 (42%)