DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10209 and Naif1

DIOPT Version :9

Sequence 1:	NP_001260982.1	Gene:	CG10209 / 36652	FlyBaseID:	FBgn0033971	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_919316.1	Gene:	Naif1 / 71254	MGIID:	1918504	Length:	327	Species:	Mus musculus

Alignment Length:	341	Identity:	64/341 - (18%)
Similarity:	103/341 - (30%)	Gaps:	108/341 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 AFHGGLHPHLLRRQHGSGSLSRESPFEEKLLQFMQDAFPKKSKKRKNRDPDKLFLLSLYEEIKRV 277
            |:||     :|||.:...:..||.|                                   |:|:.
Mouse    47 AWHG-----ILRRVNAVATCRRELP-----------------------------------EVKKK 71

  Fly   278 PEEIRLDVKSELMQILKKYQKKSPVK-AEKPAPSSTSTSS--KLSSSSSGSSTVTTHLSHSMYQL 339
            ..:::.:|:.::.|:      ::.|: .|.|.|:....:.  ...|.|.||.|....:..:..|.
Mouse    72 WSDLKTEVRRKVAQV------RAAVEGGEAPGPTEDDGAGGPGTGSGSGGSGTAIAPVLLTPMQQ 130

  Fly   340 QKKYEKGERE----PSPQSQVERVA--SAGAVAVPIHTSQQLPLFQLQKKYEENSVEKVHQQQQQ 398
            :.....||..    || .:::..||  |....|....|..|:|........||..||
Mouse   131 RICNLLGEATIISLPS-TTEIHPVALGSTATTAAATVTLTQIPTETTYHTLEEGVVE-------- 186

  Fly   399 QQSEQRKHVEAAQALHAAHQQPPP-----------PPPNEHLHHPQMAHNIMFPLGQLRNEQPTA 452
                           :...:.|||           .||:..:....:...|.....:|..||...
Mouse   187 ---------------YCTAEAPPPLPTEAPVEMIAQPPDTSVKPQALKSRIALNSAKLIQEQRVT 236

  Fly   453 QQHQHGHNPHQQQQQHPHQQQQQGQQHHPPTIFGSTASERPPMSYENVGXVLSRLWEA------- 510
            ..|......|.:||....|..::.|:      ..:.|.||...:.|.....||.|.:.
Mouse   237 NLHIKEIAQHLEQQNGLLQMIRRSQE------VQACAQERQAQAMEGTQAALSVLIQVLRPMIKD 295

  Fly   511 -----TCGAPRPATVS 521
                 ....|.||..|
Mouse   296 FRRYLQNNTPNPAPAS 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10209	NP_001260982.1	GT1	3..65	CDD:304916
CG10209	NP_001260982.1	BESS	261..295	CDD:281011	4/33 (12%)
Naif1	NP_919316.1	Required for nuclear localization and apoptosis-inducing activity. /evidence=ECO:0000250	1..70		10/62 (16%)
		Myb_DNA-bind_5	8..82	CDD:290584	12/74 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..118		8/30 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..327		4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830533
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23098
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030