DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaPi-T and VGlut

DIOPT Version :9

Sequence 1:	NP_001260981.1	Gene:	NaPi-T / 36651	FlyBaseID:	FBgn0016684	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	145/526 - (27%)
Similarity:	237/526 - (45%)	Gaps:	70/526 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ARTVLWYMTFIGFIVNYMIRINLNITIVDMIAGKGAITSNETHENSTDLAALAEMNERFSLERWF 70
            ||..:..|..:||::.:.:|.|::.
  Fly    94 ARYTIATMACVGFMIAFGMRCNMSA---------------------------------------- 118

  Fly    71 LDWANIPYEKNG---FHWNEKQQGALLGSFFWAHWTLQIPGGILATKYGTKLVFGWSNGIGVFCC 132
               |.:..|.||   .:|....:..:..||||.:...|||||.:|:|:....:||.|........
  Fly   119 ---AKLKGEHNGTVFMNWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLH 180

  Fly   133 FLIPIVSYWSYTGLII-LRVFQGWITGLAWPSMHVLTAKWIPPNERSKFVS-AYLGSSVGVALFY 195
            ..:|......:..::| :||.||...|:.:|:.|.:...|.||.|||:..: |:.||..||.:..
  Fly   181 LFVPFAMTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGL 245

  Fly   196 PIFGYIIDWTRWEWVYYICGIVGTLWFIAWQFLVFDSPAEHPRIADSERKFIEKSLGAS---IQG 257
            |:.|.:.|...::..:|..|:.|.:|::.|.:|.|::|.:||.|:..|.|:||||||.|   ...
  Fly   246 PLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSLGESAHPTMP 310

  Fly   258 SKGPTPWKAIATSRPVWLNVVAQWGGIWGLFTLMTHAPTYFRLIHHWNIRATGFLSGLPHLMRML 322
            |...|||:.:..|.||:..:||.:...|..:.|:....::.:....:.:...||:..||||:...
  Fly   311 SLKTTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTT 375

  Fly   323 FAYVFSIFADYLLRTDKMSRTNVRKLATFIC--CGTKGLIVLALAYFGYNATAAIVLVTVATMLH 385
            ......:.||:|.:...:|.||||||  |.|  .|.:||..|.:|: ...||.|:..:|......
  Fly   376 IVPFGGMLADHLRKNGILSTTNVRKL--FNCGGFGMEGLFFLFVAH-SSTATGAMFALTCGVAFS 437

  Fly   386 GAVSSGPLASMVDLSPNYAGIVLGVSGMIGGMPGFISPFIVGQLTHNNQTIDAWKNVFLLTSLML 450
            |...||...:.:|::|.||.|::|:|..||.:.|.|.|:.:..|...|.| ..|..||.|.:.:.
  Fly   438 GFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQANPT-GCWTTVFTLAACVH 501

  Fly   451 TGSGILYVLFSESKLQPWNSGCHQLPDSGLKELQNL-----GRDQDDEEEKKPLKSDHDKETPIV 510
            ......|.:|:..:||||..     |.:   |.|.:     |...:.:..:..:..|:.|||...
  Fly   502 LVGCTFYGIFASGELQPWAE-----PPA---EEQKVWAPPPGAITNTDPSQAGMLGDYMKETSFG 558

  Fly   511 AEQETK 516
            |.:.|:
  Fly   559 APEYTE 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaPi-T	NP_001260981.1	2A0114euk	1..474	CDD:129972	135/477 (28%)
NaPi-T	NP_001260981.1	MFS	76..460	CDD:119392	122/393 (31%)
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	128/460 (28%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	119/419 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.070