DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaPi-T and Slc17a8

DIOPT Version :9

Sequence 1:	NP_001260981.1	Gene:	NaPi-T / 36651	FlyBaseID:	FBgn0016684	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_714947.1	Gene:	Slc17a8 / 266767	RGDID:	628870	Length:	588	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	149/513 - (29%)
Similarity:	252/513 - (49%)	Gaps:	61/513 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VEARTVLWYMTFIGFIVNYMIRINLNITIVDMIAGKGAITSNETHENSTDLAALAEMNERFSLER 68
            :..|.::..|:.:||.:::.||.||.:.||:|:            .|||
  Rat    72 IPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMV------------NNST---------------- 108

  Fly    69 WFLDWANIPYEKNGFHWNEKQQGALLGSFFWAHWTLQIPGGILATKYGTKLVFGWSNGIGVFCCF 133
            .::| .....:...|:|:.:..|.:.|||||.:...|||||.::.|:....|||.:..:......
  Rat   109 VYVD-GKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNM 172

  Fly   134 LIPIVSYWSYTGLIILRVFQGWITGLAWPSMHVLTAKWIPPNERSKF-VSAYLGSSVGVALFYPI 197
            .||..:...|..::.:|:.||.:.|:.:|:.|.:.:||.||.|||:. .:::.||..|..:..|:
  Rat   173 FIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPL 237

  Fly   198 FGYIIDWTRWEWVYYICGIVGTLWFIAWQFLVFDSPAEHPRIADSERKFIEKSLG-----ASIQG 257
            .|.::.:..|..|:||.|:.|.:|::.|....::.||.||.|::.||.:||.|:|     ||:
  Rat   238 AGVLVQYIGWASVFYIYGMFGIIWYMFWLLQAYECPAVHPTISNEERTYIETSIGEGANLASL-- 300

  Fly   258 SKGPTPWKAIATSRPVWLNVVAQWGGIWGLFTLMTHAPTYFRLIHHWNIRATGFLSGLPHLMRML 322
            ||..|||:...||.||:..:||.:...|..:.|:...|.||..:..:.|...|.||.:||::..:
  Rat   301 SKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTI 365

  Fly   323 FAYVFSIFADYLLRTDKMSRTNVRKLATFICCGTKGLIVLALAYFGYNAT--AAIVLVTVATMLH 385
            ...:....||||.....::.|.|||:..   ||..|:....|...|::.|  .||..:.:|....
  Rat   366 VVPIGGQLADYLRSRKILTTTAVRKIMN---CGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFS 427

  Fly   386 GAVSSGPLASMVDLSPNYAGIVLGVSGMIGGMPGFISPFIVGQLTHNNQTIDAWKNVFLLTSLML 450
            |...||...:.:|::|.||.|::|:|..:|.:.|.:.|.|||.:| .::|.:.|:||||:.:|:.
  Rat   428 GFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMT-KHKTREEWQNVFLIAALVH 491

  Fly   451 TGSGILYVLFSESKLQPWNSGCHQLPDSGLKELQNLGR------DQDDEEEKKPLKSD 502
            ....|.|.:|:..:.|.|            .:.:||..      |||:..|:..|..:
  Rat   492 YSGVIFYGVFASGEKQDW------------ADPENLSEEKCGIIDQDELAEETELNHE 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaPi-T	NP_001260981.1	2A0114euk	1..474	CDD:129972	142/477 (30%)
NaPi-T	NP_001260981.1	MFS	76..460	CDD:119392	124/391 (32%)
Slc17a8	NP_714947.1	MFS_SLC17A6_7_8_VGluT	79..502	CDD:340940	138/457 (30%)
Slc17a8	NP_714947.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820