DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaPi-T and SLC17A5

DIOPT Version :9

Sequence 1:	NP_001260981.1	Gene:	NaPi-T / 36651	FlyBaseID:	FBgn0016684	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001369562.1	Gene:	SLC17A5 / 26503	HGNCID:	10933	Length:	533	Species:	Homo sapiens

Alignment Length:	485	Identity:	152/485 - (31%)
Similarity:	243/485 - (50%)	Gaps:	55/485 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ARTVLWYMTFIGFIVNYMIRINLNITIVDMIAGKGAITSNETHENSTDLAALAEMNERFSLERWF 70
            ||..|..:.|.||.:.|.:|:||::.:|||:.....:..|.|.:...:.:|..:::
Human    38 ARYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVH--------- 93

  Fly    71 LDWANIPYEKNG--FHWNEKQQGALLGSFFWAHWTLQIPGGILATKYGTKLVFGWS-NGIGVFCC 132
                   :.:.|  :.|:.:.||.:|||||:.:...|||||.:|:|.|.|::.|:. .|..|...
Human    94 -------HNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTL 151

  Fly   133 FLIPIVSYWSYTGLIILRVFQGWITGLAWPSMHVLTAKWIPPNERSKFVS-AYLGSSVGVALFYP 196
            | .||.:......||:||..:|...|:.:|:||.:.:.|.||.||||.:| :|.|:.:|..:..|
Human   152 F-TPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLP 215

  Fly   197 IFGYIIDWTRWEWVYYICGIVGTLWFIAWQFLVFDSPAEHPRIADSERKFIEKSLGASIQGSKGP 261
            :.|.|..:..|.:|:|..|.:|..||:.|.:||.|:|.:|.||:..|:::|..||...:...|.
Human   216 LSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKS- 279

  Fly   262 TPWKAIATSRPVWLNVVAQWGGIWGLFTLMTHAPTYFRLIHHWNIRATGFLSGLPHLMRMLFAYV 326
            .||..|..|.|:|..|||.:...|..:||:|..|||.:.|..:|::..||||.||:|...|...:
Human   280 VPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMIL 344

  Fly   327 FSIFADYLLRTDKMSRTNVRKLATFICCGTKGLIVLALAYFGYNATAAIVLVTVATMLHGAVSSG 391
            ....||.|......|...||::.:.|......:.::|..:.|.:.:.|:..:|::|.|.|..|||
Human   345 SGQAADNLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSG 409

  Fly   392 PLASMVDLSPNYAGIVLGVSGMIGGMPGFISPFIVGQLTHNNQTIDA---WKNVFLLTSLMLTGS 453
            ...:.:|::|:||||:||::.....:||.:.|.|...||.     ||   |:|:
Human   410 FSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTP-----DAGVQWRNL----------- 458

  Fly   454 GILYVLFSESKLQPWNSG-----CHQLPDS 478
                     |..||...|     |..||:|
Human   459 ---------SSPQPLPPGFRRFSCLSLPNS 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaPi-T	NP_001260981.1	2A0114euk	1..474	CDD:129972	149/479 (31%)
NaPi-T	NP_001260981.1	MFS	76..460	CDD:119392	128/390 (33%)
SLC17A5	NP_001369562.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Dileucine internalization motif	22..23
		MFS_SLC17A5	42..458	CDD:340939	141/438 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910