DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaPi-T and slc-17.4

DIOPT Version :9

Sequence 1:	NP_001260981.1	Gene:	NaPi-T / 36651	FlyBaseID:	FBgn0016684	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_503071.2	Gene:	slc-17.4 / 189054	WormBaseID:	WBGene00012130	Length:	573	Species:	Caenorhabditis elegans

Alignment Length:	544	Identity:	116/544 - (21%)
Similarity:	213/544 - (39%)	Gaps:	78/544 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GFIVNYMIRINLNITIVDMIAGKGAITSN----ETHENSTDL------------AALAEMNERFS 65
            ||.....:|:::.|::..||........:    |..|||:.:            ::.|::|::.
Worm    40 GFCCTTFMRMHIAISMTCMINSTALALESAVFPEAFENSSSIFEELEPVSNGACSSNADVNKKV- 103

  Fly    66 LERWFLDWANIPYEKNGFHWNEKQQGALLGSFFWAHWTLQIPGGILATKYGTKLVFGWSNGIGVF 130
                .:|:.      ....||.::|..:....||......:|......:|..:.|...:.|..:.
Worm   104 ----VVDYG------GQLVWNSQEQNLIFSGTFWGSIITVLPSMFFINRYSPRYVLQAAVGCYIL 158

  Fly   131 CCFLIPIVS--YWSYTGLIILRVFQGWITGLAWPSMHVLTAKWIPPNERSKFVSAYL-------- 185
            ...:.|.::  :..|. :.|.||..|...|...|:.:.:.|.|.|..|||..:|.:.
Worm   159 MTAITPYIATRFGPYP-VFISRVIMGLGEGFILPANNAILANWFPSAERSTAISLFTTGNQMAGA 222

  Fly   186 -GSSVGVALFYPIFGYIIDWTRWEWVYYICGIVGTLWFIAWQFLVFDSPAEHPRIADSERKFIEK 249
             |:.|..:|....||       |..::|...||.|:|.:.|.....:.|::...:..:||.:::
Worm   223 GGNPVAASLCASSFG-------WPSIFYFASIVSTIWSVCWFLTASNQPSKCKVMTKTERDYLD- 279

  Fly   250 SLGASIQGSKGPT------PWKAIATSRPVWLNVVAQWGGIWGLFTLMTHAPTYFRLIHHWNIRA 308
               |::......|      |:..|..|......::.|:...:.:..|..:.|.||:.:.|..:.|
Worm   280 ---ANVVRRSNKTNRSLVVPYSKILKSPAFLAQLLCQFVINFIVTLLQIYLPNYFKDVLHLGVIA 341

  Fly   309 TGFLSGLPHLMRMLFAYVFSIFADYLLRTDKMSRTNVRKLATFICCGTKGLIVLALAYF--GYNA 371
            .|..:.:|:::......|:.|..|.......:|.|...||:..|......|.::.:.||  ..|.
Worm   342 NGTYTSVPNIVNFALKIVWGITIDRAKEKKIISGTFGVKLSQSIANFGGALFLILITYFVDCTNP 406

  Fly   372 TAAIVLVTVATMLHGAVSSGPLASMVDLSPNYAGIVLGVSGMIGGMPGFISPFIVGQLTHNNQTI 436
            |...|...:.....|.:.||...|::.|:|.|...:..:|.....|....:|.|||.:...| |:
Worm   407 TLGFVFFCMMYGCMGTLVSGFYTSLLSLAPKYTATMSSISVFCAMMGRLATPAIVGLIKKQN-TL 470

  Fly   437 DAWKNVFLLTSLMLTGSGILYVLFSESKLQPWNSGCHQLPDSG-----------LKELQNLGRDQ 490
            ..|:.:||:.:......|.::::|...:||.|.     |.|..           |..:|||..|.
Worm   471 SEWQTLFLVCAAANIICGAVFLVFGSGELQEWG-----LEDEAKEMKTLAEKTPLASIQNLPADT 530

  Fly   491 DDEEEKKPLKSDHDKETPIVAEQE 514
            :|::   ..:|..|.|.|.:...|
Worm   531 EDQD---IFQSALDMEIPEIQLNE 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaPi-T	NP_001260981.1	2A0114euk	1..474	CDD:129972	103/491 (21%)
NaPi-T	NP_001260981.1	MFS	76..460	CDD:119392	86/402 (21%)
slc-17.4	NP_503071.2	MFS	34..495	CDD:391944	99/478 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020