DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaPi-T and SLC17A3

DIOPT Version :9

Sequence 1:	NP_001260981.1	Gene:	NaPi-T / 36651	FlyBaseID:	FBgn0016684	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001091956.1	Gene:	SLC17A3 / 10786	HGNCID:	10931	Length:	498	Species:	Homo sapiens

Alignment Length:	470	Identity:	135/470 - (28%)
Similarity:	221/470 - (47%)	Gaps:	34/470 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VLWYMTFIGFIVNYMIRINLNITIVDMIAGKGAITSNETHENSTDLAALAEMNERFSLERWFLDW 73
            ||.:..|.....|    :.:|||:|.|:             |||  :..:::|:  |.|...:|.
Human    44 VLHFCNFTTIAQN----VIMNITMVAMV-------------NST--SPQSQLND--SSEVLPVDS 87

  Fly    74 --------ANIPYEKNGFHWNEKQQGALLGSFFWAHWTLQIPGGILATKYGTKLVFGWSNGIGVF 130
                    .::|.:...:.|:.:.||.:.|:..:.......|.|.||.:.|||.|.|.|.....|
Human    88 FGGLSKAPKSLPAKAPVYDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSF 152

  Fly   131 CCFLIPIVSYWSYTGLIILRVFQGWITGLAWPSMHVLTAKWIPPNERSKFVS-AYLGSSVGVALF 194
            ....||:.:.:....||:.|:.||............:..||.||.|||:..| |..|..:|....
Human   153 LTLCIPLATDFGIVLLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTA 217

  Fly   195 YPIFGYIIDWTRWEWVYYICGIVGTLWFIAWQFLVFDSPAEHPRIADSERKFIEKSLGASIQGSK 259
            ..|.|:|.:...|.:|:||.|.||.:..:.|..:::|.|..:|.|:.||:::|..||...:..||
Human   218 ILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYIISSLKQQVGSSK 282

  Fly   260 GPTPWKAIATSRPVWLNVVAQWGGIWGLFTLMTHAPTYFRLIHHWNIRATGFLSGLPHLMRMLFA 324
            .|.|.||:..|.|:|...:..:...|.:.|::.:.|||...::|.|||..|.||.||.::..:..
Human   283 QPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIG 347

  Fly   325 YVFSIFADYLLRTDKMSRTNVRKLATFICCGTKGLIVLALAYFGYNATAAIVLVTVATMLHGAVS 389
            .|....||:|| |.|.....|||:||.:.......::::|.|.......|..|:|::..|.....
Human   348 MVGGYLADFLL-TKKFRLITVRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQ 411

  Fly   390 SGPLASMVDLSPNYAGIVLGVSGMIGGMPGFISPFIVGQLTHNNQTIDAWKNV-FLLTSLMLTGS 453
            ||...:::|::|.|:..::|.|.....:...|.|.:.|.|...:... .|:|| |||.::.|.|.
Human   412 SGIYINVLDIAPRYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDPEF-GWRNVFFLLFAVNLLGL 475

  Fly   454 GILYVLFSESKLQPW 468
             :.|::|.|:.:|.|
Human   476 -LFYLIFGEADVQEW 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaPi-T	NP_001260981.1	2A0114euk	1..474	CDD:129972	135/470 (29%)
NaPi-T	NP_001260981.1	MFS	76..460	CDD:119392	115/385 (30%)
SLC17A3	NP_001091956.1	2A0114euk	23..497	CDD:129972	135/470 (29%)
SLC17A3	NP_001091956.1	MFS	98..481	CDD:119392	115/385 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820