Protein Alignment Pgm2b and PRM15

DIOPT Version :10

• Sequence 1: NP_610992.2
• Gene: Pgm2b / 36649
• FlyBaseID: FBgn0033969
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: NP_014005.1
• Gene: PRM15 / 855321
• SGDID: S000004891
• Length: 622
• Species: Saccharomyces cerevisiae
• Alignment Length: 631
• Identity: 219/631 - (34%)
• Similarity: 328/631 - (51%)
• Gaps: 44/631 - (6%)

  Fly    14 QELLKTLELSGEEDLDLQIKNWVMWDRNEATLQQVTEAVRDQDWKALRVRLCHRITYLTTGLRGV 78
            |.:|:|:    ..||...|..|...|||..|:::||...:..||..|..|...||.:.|.|||..
Yeast     3 QGILETV----PSDLKDPISLWFKQDRNPKTIEEVTALCKKSDWNELHKRFDSRIQFGTAGLRSQ 63

  Fly    79 MRAGFDSLNDVVIIEVAQGICAYLVDAYPSIQKRQTQGVVVGYDGRYNSKRFAQLIATVFLNNDF 143
            |:|||..:|.:|:|:.:||:..|:...:|     .....|||:|.|::||.||:..|..||...|
Yeast    64 MQAGFSRMNTLVVIQASQGLATYVRQQFP-----DNLVAVVGHDHRFHSKEFARATAAAFLLKGF 123

  Fly   144 KVFLFT---RMIPTPFIPFTVVTLQCLAGIVVTASHNVKEDNGIKVYWSNGAQAMAPHDQRIHDY 205
            ||....   ..:.||.:||.|..|:...|:::|||||.|.|||.|||:|||.|.:.|||..|.|.
Yeast   124 KVHYLNPDHEFVHTPLVPFAVDKLKASVGVMITASHNPKMDNGYKVYYSNGCQIIPPHDHAISDS 188

  Fly   206 MMNNLEPKPSSWETSLVLDHPLVEDPY----RQIYPLFYEAL-KTL--IPPIYLETNECSQLRFI 263
            :..||||..:.|:...||:..|.:...    .::..|:.|.: |.|  |.|:.||..  ::..|:
Yeast   189 IDANLEPWANVWDFDDVLNKALKQGKLMYSREEMLKLYLEEVSKNLVEINPLKLEVK--AKPWFV 251

  Fly   264 YTALHGVGY----PFMREAFYQARLKPVIPVVEQKEADPEFPTLVKPNPEEGKEALKLAIKKADA 324
            ||.:||||:    ..:::.......|..:.|.||:..||.|||:..||||| |.||.:.|..|:.
Yeast   252 YTPMHGVGFDIFSTIVKKTLCLVEGKDYLCVPEQQNPDPSFPTVGFPNPEE-KGALDIGINLAEK 315

  Fly   325 EHCTLVLANDPDVDRLAVAELDPR-GRWKLFNGNELGALLGWWALENYKTRTPK-PAVTNCIMIA 387
            ....|::|||||.||.:||..|.: |.|:...|||:|.|..::..:.||:...: ..|....|:.
Yeast   316 HDIDLLVANDPDADRFSVAVKDMQSGEWRQLTGNEIGFLFAFYEYQKYKSMDKEFQHVHPLAMLN 380

  Fly   388 TLVSSRILAAMARVEGFIFVEGMPSFPWMAHRALELEKSGRTVLFAFEECFGYMFGMSLPDKDGI 452
            :.|||:::..||.:|||.:.:.:..|.|:.:||:.|||.|..|.|.|||..||||.....|||||
Yeast   381 STVSSQMIKKMAEIEGFHYEDTLTGFKWIGNRAILLEKKGYYVPFGFEEAIGYMFPAMEHDKDGI 445

  Fly   453 GAAMQLASMACYLRSTRNVTLIEKLREIYDTYGYHSSISSVYMADSPETITSVFDHLRNFTDEEG 517
            .|::......|..:...|:..:..|...:..||.....:..|:..:|.....:||::||....||
Yeast   446 SASIVFLQAYCKWKIDHNLDPLNVLENGFKKYGVFKEYNGYYVVPNPTVTKDIFDYIRNVYTPEG 510

  Fly   518 --YPKFILDEEFEVVHIRDLTIGLDTSFSDGKARMPVTPDAQLITFTF--TNG-----YVVTLRS 573
              ||..| .||.||::.||||.|..:...:.|..:||.|.:|:||.:.  :||     ...|:|.
Yeast   511 ASYPSSI-GEEIEVLYYRDLTTGYQSDTINHKPTLPVDPTSQMITVSARPSNGSENEHIRFTIRG 574

  Fly   574 APNDIKIKLNAEICGLPEEKQWEELHDKLNRMT-NAVVEEFLQPEE 618
            :..:.|:|:..|.|...|::.     ..|.::| |.:..|:.:|:|
Yeast   575 SGTEPKLKVYIEACANEEQRA-----SFLAKLTWNVLRREWFRPDE 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgm2b	NP_610992.2	PTZ00150	26..621	CDD:240294	216/619 (35%)
PRM15	NP_014005.1	PGM2	52..596	CDD:100092	196/557 (35%)