DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgm2b and PRM15

DIOPT Version :9

Sequence 1:	NP_610992.2	Gene:	Pgm2b / 36649	FlyBaseID:	FBgn0033969	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_014005.1	Gene:	PRM15 / 855321	SGDID:	S000004891	Length:	622	Species:	Saccharomyces cerevisiae

Alignment Length:	631	Identity:	219/631 - (34%)
Similarity:	328/631 - (51%)	Gaps:	44/631 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QELLKTLELSGEEDLDLQIKNWVMWDRNEATLQQVTEAVRDQDWKALRVRLCHRITYLTTGLRGV 78
            |.:|:|:    ..||...|..|...|||..|:::||...:..||..|..|...||.:.|.|||..
Yeast     3 QGILETV----PSDLKDPISLWFKQDRNPKTIEEVTALCKKSDWNELHKRFDSRIQFGTAGLRSQ 63

  Fly    79 MRAGFDSLNDVVIIEVAQGICAYLVDAYPSIQKRQTQGVVVGYDGRYNSKRFAQLIATVFLNNDF 143
            |:|||..:|.:|:|:.:||:..|:...:|     .....|||:|.|::||.||:..|..||...|
Yeast    64 MQAGFSRMNTLVVIQASQGLATYVRQQFP-----DNLVAVVGHDHRFHSKEFARATAAAFLLKGF 123

  Fly   144 KVFLFT---RMIPTPFIPFTVVTLQCLAGIVVTASHNVKEDNGIKVYWSNGAQAMAPHDQRIHDY 205
            ||....   ..:.||.:||.|..|:...|:::|||||.|.|||.|||:|||.|.:.|||..|.|.
Yeast   124 KVHYLNPDHEFVHTPLVPFAVDKLKASVGVMITASHNPKMDNGYKVYYSNGCQIIPPHDHAISDS 188

  Fly   206 MMNNLEPKPSSWETSLVLDHPLVEDPY----RQIYPLFYEAL-KTL--IPPIYLETNECSQLRFI 263
            :..||||..:.|:...||:..|.:...    .::..|:.|.: |.|  |.|:.||..  ::..|:
Yeast   189 IDANLEPWANVWDFDDVLNKALKQGKLMYSREEMLKLYLEEVSKNLVEINPLKLEVK--AKPWFV 251

  Fly   264 YTALHGVGY----PFMREAFYQARLKPVIPVVEQKEADPEFPTLVKPNPEEGKEALKLAIKKADA 324
            ||.:||||:    ..:::.......|..:.|.||:..||.|||:..||||| |.||.:.|..|:.
Yeast   252 YTPMHGVGFDIFSTIVKKTLCLVEGKDYLCVPEQQNPDPSFPTVGFPNPEE-KGALDIGINLAEK 315

  Fly   325 EHCTLVLANDPDVDRLAVAELDPR-GRWKLFNGNELGALLGWWALENYKTRTPK-PAVTNCIMIA 387
            ....|::|||||.||.:||..|.: |.|:...|||:|.|..::..:.||:...: ..|....|:.
Yeast   316 HDIDLLVANDPDADRFSVAVKDMQSGEWRQLTGNEIGFLFAFYEYQKYKSMDKEFQHVHPLAMLN 380

  Fly   388 TLVSSRILAAMARVEGFIFVEGMPSFPWMAHRALELEKSGRTVLFAFEECFGYMFGMSLPDKDGI 452
            :.|||:::..||.:|||.:.:.:..|.|:.:||:.|||.|..|.|.|||..||||.....|||||
Yeast   381 STVSSQMIKKMAEIEGFHYEDTLTGFKWIGNRAILLEKKGYYVPFGFEEAIGYMFPAMEHDKDGI 445

  Fly   453 GAAMQLASMACYLRSTRNVTLIEKLREIYDTYGYHSSISSVYMADSPETITSVFDHLRNFTDEEG 517
            .|::......|..:...|:..:..|...:..||.....:..|:..:|.....:||::||....||
Yeast   446 SASIVFLQAYCKWKIDHNLDPLNVLENGFKKYGVFKEYNGYYVVPNPTVTKDIFDYIRNVYTPEG 510

  Fly   518 --YPKFILDEEFEVVHIRDLTIGLDTSFSDGKARMPVTPDAQLITFTF--TNG-----YVVTLRS 573
              ||..| .||.||::.||||.|..:...:.|..:||.|.:|:||.:.  :||     ...|:|.
Yeast   511 ASYPSSI-GEEIEVLYYRDLTTGYQSDTINHKPTLPVDPTSQMITVSARPSNGSENEHIRFTIRG 574

  Fly   574 APNDIKIKLNAEICGLPEEKQWEELHDKLNRMT-NAVVEEFLQPEE 618
            :..:.|:|:..|.|...|::.     ..|.::| |.:..|:.:|:|
Yeast   575 SGTEPKLKVYIEACANEEQRA-----SFLAKLTWNVLRREWFRPDE 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgm2b	NP_610992.2	PTZ00150	26..621	CDD:240294	216/619 (35%)
Pgm2b	NP_610992.2	PGM2	67..607	CDD:100092	198/565 (35%)
PRM15	NP_014005.1	PGM2	52..596	CDD:100092	196/557 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343733
Domainoid	1	1.000	148	1.000	Domainoid score	I958
eggNOG	1	0.900	-	-		E1_COG1109
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6693
Inparanoid	1	1.050	398	1.000	Inparanoid score	I316
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S1166
OMA	1	1.010	-	-		QHG53730
OrthoFinder	1	1.000	-	-		FOG0002126
OrthoInspector	1	1.000	-	-		otm46675
orthoMCL	1	0.900	-	-		OOG6_100912
Panther	1	1.100	-	-	O	PTHR45745
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1578
TreeFam	1	0.960	-	-
	15	14.710