DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgm2b and Pgm2l1

DIOPT Version :9

Sequence 1:	NP_610992.2	Gene:	Pgm2b / 36649	FlyBaseID:	FBgn0033969	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001102924.1	Gene:	Pgm2l1 / 685076	RGDID:	1583226	Length:	621	Species:	Rattus norvegicus

Alignment Length:	612	Identity:	271/612 - (44%)
Similarity:	388/612 - (63%)	Gaps:	14/612 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLKTLELSGEEDLDLQIKNWVMWDRNEATLQQVTEAVRDQDWKALRVRLCHRITYLTTGLRGVMR 80
            ||....|:|:..||..|..|:.||:|..|.:|:...:|:...|.||.|||.|:|:.|.|||..|.
  Rat    13 LLHAPYLTGDPQLDTAIGQWLRWDKNPKTKEQIENLLRNGMNKELRDRLCCRMTFGTAGLRSAMG 77

  Fly    81 AGFDSLNDVVIIEVAQGICAYLVDAYPSIQKRQTQGVVVGYDGR------YNSKRFAQLIATVFL 139
            |||..:||:.:|:..||:..||...:...::|   |.|||||.|      .:|:|.|:|.|.|.|
  Rat    78 AGFCYINDLTVIQSTQGMYKYLERCFSDFKQR---GFVVGYDTRGQVTSSCSSQRLAKLTAAVLL 139

  Fly   140 NNDFKVFLFTRMIPTPFIPFTVVTLQCLAGIVVTASHNVKEDNGIKVYWSNGAQAMAPHDQRIHD 204
            ..|..|:||:|.:||||:|:.|..|:.:||:::|||||.|||||.||||..|||..:|||:.|..
  Rat   140 AKDVPVYLFSRYVPTPFVPYAVQELKAVAGVMITASHNRKEDNGYKVYWETGAQITSPHDKEILK 204

  Fly   205 YMMNNLEPKPSSWETSLVLDHPLVEDPYRQIYPLFYEALKTLIPPIYLETNECSQLRFIYTALHG 269
            .:...:||...||..:||...||.:||.:.|...:.|.||.:.  .|.:.|..:.|:|::|:.||
  Rat   205 CIEECVEPWDDSWNDNLVDTSPLKKDPLQDICRRYMEDLKKIC--FYRDLNSKTTLKFVHTSFHG 267

  Fly   270 VGYPFMREAFYQARLKPVIPVVEQKEADPEFPTLVKPNPEEGKEALKLAIKKADAEHCTLVLAND 334
            ||:.:::.||.....||.|||.|||:.||:|.|:..||||||:..|:|:::.|:.|:..:|||.|
  Rat   268 VGHDYVQLAFQVFGFKPPIPVPEQKDPDPDFSTVKCPNPEEGESVLELSLRLAEKENARIVLATD 332

  Fly   335 PDVDRLAVAELDPRGRWKLFNGNELGALLGWWALENYKTRTPKPAVTNCIMIATLVSSRILAAMA 399
            ||.||||||||...|.||:|.||||.||.|||..:.:|...|...|.|..|:||.|||:||.|:|
  Rat   333 PDADRLAVAELQENGHWKVFTGNELAALFGWWMFDCWKKSKPNADVKNVYMLATTVSSKILKAIA 397

  Fly   400 RVEGFIFVEGMPSFPWMAHRALELEKSGRTVLFAFEECFGYMFGMSLPDKDGIGAAMQLASMACY 464
            ..|||.|.|.:|.|.|:..|..:|...|:.|||||||..|::.|.|:.||||:.||:.:|.||.:
  Rat   398 LKEGFHFEETLPGFKWIGSRIKDLLGHGKEVLFAFEESIGFLCGTSVLDKDGVSAAVVVAEMAAF 462

  Fly   465 LRSTRNVTLIEKLREIYDTYGYHSSISSVYMADSPETITSVFDHLRNFTDEEGYPKFILDEEFEV 529
            | ..|.|||:|:|.::|:|||||.|.:|.::...|.||.::|:.:|||...:.||||.  ..|.:
  Rat   463 L-DARKVTLMEQLMKVYETYGYHMSKTSYFLCYDPPTIKTIFERIRNFESPKEYPKFC--GAFAI 524

  Fly   530 VHIRDLTIGLDTSFSDGKARMPVTPDAQLITFTFTNGYVVTLRSAPNDIKIKLNAEICGLPEEKQ 594
            :|:||:|.|.|:|..:.|:.:||:.::|:|||||.||.|.|||::..:.|||..||:|..|.:..
  Rat   525 LHVRDITTGYDSSQPNKKSVLPVSKNSQMITFTFQNGCVATLRTSGTEPKIKYYAEMCASPGQSD 589

  Fly   595 WEELHDKLNRMTNAVVEEFLQPEENGL 621
            ...|.::|.::.:|::|.||:|.:|||
  Rat   590 TALLEEELKKLIDALIENFLEPSKNGL 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgm2b	NP_610992.2	PTZ00150	26..621	CDD:240294	265/600 (44%)
Pgm2b	NP_610992.2	PGM2	67..607	CDD:100092	243/545 (45%)
Pgm2l1	NP_001102924.1	PTZ00150	24..620	CDD:240294	267/601 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4186
eggNOG	1	0.900	-	-		E1_COG1109
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	589	1.000	Inparanoid score	I956
OMA	1	1.010	-	-		QHG53730
OrthoDB	1	1.010	-	-		D1041556at2759
OrthoFinder	1	1.000	-	-		FOG0002126
OrthoInspector	1	1.000	-	-		mtm9036
orthoMCL	1	0.900	-	-		OOG6_100912
Panther	1	1.100	-	-	O	PTHR45745
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1578
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840