DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgm2b and pgm2l1

DIOPT Version :9

Sequence 1:	NP_610992.2	Gene:	Pgm2b / 36649	FlyBaseID:	FBgn0033969	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001091955.1	Gene:	pgm2l1 / 449945	ZFINID:	ZDB-GENE-041008-205	Length:	619	Species:	Danio rerio

Alignment Length:	613	Identity:	267/613 - (43%)
Similarity:	379/613 - (61%)	Gaps:	15/613 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LELSGEEDLDLQIKNWVMWDRNEATLQQVTEAVRDQDWKALRVRLCHRITYLTTGLRGVMRAGFD 84
            |..:|:..||..:..|:.||:|..|.:|:...|::.....||.|||.|:|:.|.|||..|.|||.
Zfish    14 LSATGDPVLDKAVSQWMTWDKNPLTREQIESLVQEGRVVELRRRLCSRMTFGTAGLRAAMGAGFA 78

  Fly    85 SLNDVVIIEVAQGICAYLVDAYPSIQKRQTQGVVVGYDGR------YNSKRFAQLIATVFLNNDF 143
            .:||:.||:..||:..||...:|.:   :|:|:|||||.|      ..|:|.|:|.|.|.|..|.
Zfish    79 RINDLTIIQSTQGLYKYLAKCFPDL---KTRGLVVGYDTRAQASSGCTSERLAKLTAAVMLCKDV 140

  Fly   144 KVFLFTRMIPTPFIPFTVVTLQCLAGIVVTASHNVKEDNGIKVYWSNGAQAMAPHDQRIHDYMMN 208
            .|:||:..:||||:|:.|:.....||:::|||||.|||||.||||.||||..:|||:.|...:..
Zfish   141 PVYLFSTYVPTPFVPYAVMKYGAAAGVMITASHNRKEDNGYKVYWHNGAQIASPHDKEILHCIEE 205

  Fly   209 NLEPKPSSWETSLVLDHPLVEDPYRQIYPLFYEALKTLIPPIYLETNECSQLRFIYTALHGVGYP 273
            :.||...||...||.:..|..||...:...:.|.|.||.  .:.|.|..|.|:|::::.||||:.
Zfish   206 SAEPWAESWNEDLVENSLLKRDPLEDVCHWYMEELNTLC--FHRELNAKSPLKFVHSSFHGVGHN 268

  Fly   274 FMREAFYQARLKPVIPVVEQKEADPEFPTLVKPNPEEGKEALKLAIKKADAEHCTLVLANDPDVD 338
            :::.||.|....|.|||.|||:.||:|.|:..||||||:..|:|:::.|:.|...:|:|.|||.|
Zfish   269 YVQRAFQQFGFPPPIPVPEQKDPDPDFSTVSCPNPEEGESVLELSLRLAEREKARIVVATDPDAD 333

  Fly   339 RLAVAELDPRGRWKLFNGNELGALLGWWALENYKTRTPKPAVTNCI-MIATLVSSRILAAMARVE 402
            ||||||.:....||:|.||||.||||||.|.|:|...|.||.|..: |:||.|||:||.|.||:|
Zfish   334 RLAVAEQNDNCGWKVFTGNELAALLGWWMLFNWKEAHPDPADTERVYMLATTVSSKILEAFARIE 398

  Fly   403 GFIFVEGMPSFPWMAHRALELEKSGRTVLFAFEECFGYMFGMSLPDKDGIGAAMQLASMACYLRS 467
            ||.|.|.:|.|.|:.:|..||:|:|:.|:|:|||..|::.|..:.||||:..|..:|.||.||.
Zfish   399 GFHFEETLPGFKWIGNRIHELKKAGKEVIFSFEESIGFLCGNMVLDKDGVSTAAVVAEMASYLH- 462

  Fly   468 TRNVTLIEKLREIYDTYGYHSSISSVYMADSPETITSVFDHLRNFTDEEGYPKFILDEEFEVVHI 532
            |:|::|.::|..||:.||||.|.:|..:.:.|.||..:|..||||..:..||....|  :.:.||
Zfish   463 TKNLSLNQQLCNIYEIYGYHISRTSYVLCNDPPTIHRIFSRLRNFGGQGVYPTSCGD--YCITHI 525

  Fly   533 RDLTIGLDTSFSDGKARMPVTPDAQLITFTFTNGYVVTLRSAPNDIKIKLNAEICGLPEEKQWEE 597
            ||:|.|.|:|..|.|..:|::..:|::||||.||.|.|||::..:.|||...|.|..|.|:....
Zfish   526 RDVTTGYDSSQPDKKCVLPLSKSSQMLTFTFQNGIVATLRTSGTEPKIKYYTEFCASPGERDISS 590

  Fly   598 LHDKLNRMTNAVVEEFLQPEENGLTDAS 625
            |.::|.::..|:|||||:|::|.|...|
Zfish   591 LDEELRKVAAALVEEFLEPDKNDLLGRS 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgm2b	NP_610992.2	PTZ00150	26..621	CDD:240294	263/601 (44%)
Pgm2b	NP_610992.2	PGM2	67..607	CDD:100092	241/546 (44%)
pgm2l1	NP_001091955.1	PTZ00150	22..618	CDD:240294	264/603 (44%)
pgm2l1	NP_001091955.1	PGM2	61..600	CDD:100092	241/546 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I4314
eggNOG	1	0.900	-	-		E1_COG1109
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	576	1.000	Inparanoid score	I1006
OMA	1	1.010	-	-		QHG53730
OrthoDB	1	1.010	-	-		D1041556at2759
OrthoFinder	1	1.000	-	-		FOG0002126
OrthoInspector	1	1.000	-	-		mtm6464
orthoMCL	1	0.900	-	-		OOG6_100912
Panther	1	1.100	-	-	O	PTHR45745
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1578
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840