DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgm2b and Pgm2a

DIOPT Version :9

Sequence 1:	NP_610992.2	Gene:	Pgm2b / 36649	FlyBaseID:	FBgn0033969	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_610453.1	Gene:	Pgm2a / 35923	FlyBaseID:	FBgn0033377	Length:	623	Species:	Drosophila melanogaster

Alignment Length:	609	Identity:	323/609 - (53%)
Similarity:	437/609 - (71%)	Gaps:	6/609 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LKTLELSGEEDLDLQIKNWVMWDRNEATLQQVTEAVRDQDWKALRVRLCHRITYLTTGLRGVMRA 81
            :|.:.|||:.:||.:|:.|:.||:..:|..|:.:|||.:||..||.|||.||::.|.|||..|||
  Fly    12 IKNMALSGDPELDGEIRKWIRWDKCASTACQIMDAVRAKDWDTLRKRLCTRISFGTAGLRACMRA 76

  Fly    82 GFDSLNDVVIIEVAQGICAYLVDAYPSIQKRQTQGVVVGYDGRYNSKRFAQLIATVFLNNDFKVF 146
            ||||:|::|:|:.|||:|.|:.:.||.......:|:|.||||||||.|||:|.|.|||||||||:
  Fly    77 GFDSMNELVVIQTAQGLCEYIKEQYPDPADWSGRGIVFGYDGRYNSHRFAELSAIVFLNNDFKVW 141

  Fly   147 LFTRMIPTPFIPFTVVTLQCLAGIVVTASHNVKEDNGIKVYWSNGAQAMAPHDQRIHDYMMNNLE 211
            ||.|.:.||.:||.::.||||||::||||||.|||||.||||:||||.:.|||:.|.:.::||||
  Fly   142 LFKRYVATPMVPFAILRLQCLAGVMVTASHNPKEDNGYKVYWTNGAQIIPPHDEGIQESILNNLE 206

  Fly   212 PKPSSWETSLVLDHPLVEDPYRQIYPLFYEALKTLIPPIYLETNECSQLRFIYTALHGVGYPFMR 276
            ||.|||:.|.:..:.::||||..:.|.:::.||..:|...||.|....|.|.|||:|||||.|::
  Fly   207 PKGSSWDDSAMCSNTMLEDPYDIVVPPYFDILKKQLPCTSLEANGRCSLSFTYTAMHGVGYAFVK 271

  Fly   277 EAFYQARLKPVIPVVEQKEADPEFPTLVKPNPEEGKEALKLAIKKADAEHCTLVLANDPDVDRLA 341
            :||.:..|||.|.|.||:|.||||||...|||||||.:|.|:||.|.|....::||||||.||||
  Fly   272 QAFARINLKPFISVCEQQEPDPEFPTTPMPNPEEGKTSLDLSIKTAKANSSQIILANDPDADRLA 336

  Fly   342 VAELDPRGRWKLFNGNELGALLGWWALENYKTRTPKPAVTNCIMIATLVSSRILAAMARVEGFIF 406
            |||:...|.:|||:|||:|||||||:||.:|.|.|...|:||:|||:.|||:||.|||..|||.|
  Fly   337 VAEVREDGSYKLFSGNEVGALLGWWSLELHKMREPDCDVSNCVMIASTVSSKILRAMAEREGFQF 401

  Fly   407 VEGMPSFPWMAHRALELEKSGRTVLFAFEECFGYMFGMSLPDKDGIGAAMQLASMACYLRSTRNV 471
            .|.:..|.||.::|:||:::|:||||||||..|:|.|.::.||||:.||..||:||||||....:
  Fly   402 FETLTGFKWMGNKAIELQQAGKTVLFAFEEAIGFMVGTTVLDKDGVSAAGHLATMACYLRCKLCM 466

  Fly   472 TLIEKLREIYDTYGYHSSISSVYMADSPETITSVFDHLRNFTDEEG----YPKFILDEEFEVVHI 532
            ||.||||:||:|||:|:::||..:...|..|..:|:.||  |.:||    ||..||:.|:|:.::
  Fly   467 TLQEKLRDIYETYGFHTTVSSYVICRCPPVIEQIFERLR--TWDEGKADTYPTSILNGEYEIENV 529

  Fly   533 RDLTIGLDTSFSDGKARMPVTPDAQLITFTFTNGYVVTLRSAPNDIKIKLNAEICGLPEEKQWEE 597
            ||||.|.|:|..|.||.:|.:..:|:|||||.||.|||||::..:.|:|..||:||.|:||.|.:
  Fly   530 RDLTTGFDSSTGDKKATLPTSSSSQMITFTFKNGLVVTLRTSGTEPKMKYYAEMCGKPDEKNWAK 594

  Fly   598 LHDKLNRMTNAVVEEFLQPEENGL 621
            |.:.:|.|..|:||||.:|.:|||
  Fly   595 LTNTMNTMVEAIVEEFYEPSKNGL 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgm2b	NP_610992.2	PTZ00150	26..621	CDD:240294	317/598 (53%)
Pgm2b	NP_610992.2	PGM2	67..607	CDD:100092	292/543 (54%)
Pgm2a	NP_610453.1	PTZ00150	23..623	CDD:240294	319/598 (53%)
Pgm2a	NP_610453.1	PGM2	62..604	CDD:100092	292/543 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448735
Domainoid	1	1.000	151	1.000	Domainoid score	I4314
eggNOG	1	0.900	-	-		E1_COG1109
Homologene	1	1.000	-	-		H6693
Inparanoid	1	1.050	576	1.000	Inparanoid score	I1006
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S1166
OMA	1	1.010	-	-		QHG53730
OrthoDB	1	1.010	-	-		D1041556at2759
OrthoFinder	1	1.000	-	-		FOG0002126
OrthoInspector	1	1.000	-	-		mtm6464
orthoMCL	1	0.900	-	-		OOG6_100912
Panther	1	1.100	-	-	P	PTHR45745
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1578
	14	13.760