DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgm2b and Pgm2

DIOPT Version :9

Sequence 1:	NP_610992.2	Gene:	Pgm2b / 36649	FlyBaseID:	FBgn0033969	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001099477.2	Gene:	Pgm2 / 289632	RGDID:	1306061	Length:	620	Species:	Rattus norvegicus

Alignment Length:	611	Identity:	255/611 - (41%)
Similarity:	374/611 - (61%)	Gaps:	18/611 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ELSG---EEDLDLQIKNWVMWDRNEATLQQVTEAVRDQDWKALRVRLCHRITYLTTGLRGVMRAG 82
            |.||   :..||.:...|:.||||..|.:.|.:.:.:.:.:.|......|:.:.|.|||..|.||
  Rat    13 EASGLGMDARLDQETAQWLRWDRNPLTSESVKQLLAEGNKEELEKCFGARMEFGTAGLRAPMGAG 77

  Fly    83 FDSLNDVVIIEVAQGICAYLVDAYPSIQKRQTQGVVVGYDGRY------NSKRFAQLIATVFLNN 141
            ...:||:.||:..||.|.||...:..:::|   |||:.:|||.      :|:|||:|.||.|::.
  Rat    78 ISRMNDLTIIQTTQGFCRYLEKQFSDLKQR---GVVISFDGRAHPASGGSSRRFARLAATAFISQ 139

  Fly   142 DFKVFLFTRMIPTPFIPFTVVTLQCLAGIVVTASHNVKEDNGIKVYWSNGAQAMAPHDQRIHDYM 206
            ...|.||:.:.||||:|:||..|:..|||::|||||.|:|||.||||.||||.::|||:.|...:
  Rat   140 GVPVHLFSDITPTPFVPYTVSHLKLCAGIMITASHNPKQDNGYKVYWDNGAQIISPHDRGISQAI 204

  Fly   207 MNNLEPKPSSWETSLVLDHPLVEDPYRQIYPLFYEALKTLIPPIYLETNECSQLRFIYTALHGVG 271
            ..||||.|.:|:.||:....|:.:|...|...::|.||...  .:...|..||::|::|::||||
  Rat   205 EENLEPWPQAWDESLIDSSSLLHNPSTSISNDYFEDLKKYC--FHRTVNRESQVKFVHTSVHGVG 267

  Fly   272 YPFMREAFYQARLKPVIPVVEQKEADPEFPTLVKPNPEEGKEALKLAIKKADAEHCTLVLANDPD 336
            :.|::.||....|.|...|.:||:.||||||:..|||||||..|.|:.:.||.....:|||||||
  Rat   268 HEFVQSAFKAFDLNPPEAVPQQKDPDPEFPTVKYPNPEEGKGVLTLSFELADKIKAKIVLANDPD 332

  Fly   337 VDRLAVAELDPRGRWKLFNGNELGALLGWWALENYKTRTP-KPAVTNCIMIATLVSSRILAAMAR 400
            .|||||||....|.|::|:|||||||||||...::|.:.. :..:.:..|:::.|||:||.|:|.
  Rat   333 ADRLAVAEKQDSGEWRVFSGNELGALLGWWLFTSWKEKNQGQSNLKDTYMLSSTVSSKILRAIAL 397

  Fly   401 VEGFIFVEGMPSFPWMAHRALELEKSGRTVLFAFEECFGYMFGMSLPDKDGIGAAMQLASMACYL 465
            .|||.|.|.:..|.||.:||.:|...|:||||||||..|||....:.||||:.||:..|.:..:|
  Rat   398 KEGFHFEETLTGFKWMGNRAKQLIDQGKTVLFAFEEAIGYMCCPFVLDKDGVSAAVISAELVSFL 462

  Fly   466 RSTRNVTLIEKLREIYDTYGYHSSISSVYMADSPETITSVFDHLRNFTDEEGYPKFILDEEFEVV 530
             :|:|::|..:|:.||..||||.:.:|.::.....||..:|::|||:..:..|||..  .:||:.
  Rat   463 -ATKNLSLSLQLKAIYLEYGYHITTASYFICHDQGTIQKLFENLRNYDGKNKYPKTC--GKFEIS 524

  Fly   531 HIRDLTIGLDTSFSDGKARMPVTPDAQLITFTFTNGYVVTLRSAPNDIKIKLNAEICGLPEEKQW 595
            .:||||.|.|::..|.||.:|.:..:|:|||||.||.|.|:|::..:.|||..||:|..|.....
  Rat   525 AVRDLTTGYDSNQPDKKAVLPTSKSSQMITFTFVNGGVATMRTSGTEPKIKYYAELCAPPGNSDP 589

  Fly   596 EELHDKLNRMTNAVVEEFLQPEENGL 621
            |:|..:|:.:..|:.|.|.||::..|
  Rat   590 EQLKRELDELVGAIEEHFFQPQKYNL 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgm2b	NP_610992.2	PTZ00150	26..621	CDD:240294	251/601 (42%)
Pgm2b	NP_610992.2	PGM2	67..607	CDD:100092	236/546 (43%)
Pgm2	NP_001099477.2	PTZ00150	19..620	CDD:240294	252/605 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4186
eggNOG	1	0.900	-	-		E1_COG1109
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	589	1.000	Inparanoid score	I956
OMA	1	1.010	-	-		QHG53730
OrthoDB	1	1.010	-	-		D1041556at2759
OrthoFinder	1	1.000	-	-		FOG0002126
OrthoInspector	1	1.000	-	-		mtm9036
orthoMCL	1	0.900	-	-		OOG6_100912
Panther	1	1.100	-	-	O	PTHR45745
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1578
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840