Protein Alignment Pgm2b and PGM2L1

DIOPT Version :10

• Sequence 1: NP_610992.2
• Gene: Pgm2b / 36649
• FlyBaseID: FBgn0033969
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: XP_011543255.1
• Gene: PGM2L1 / 283209
• HGNCID: 20898
• Length: 643
• Species: Homo sapiens
• Alignment Length: 627
• Identity: 270/627 - (43%)
• Similarity: 387/627 - (61%)
• Gaps: 36/627 - (5%)

  Fly    23 SGEEDLDLQIKNWVMWDR---------------------NEATLQQVTEAVRDQDWKALRVRLCH 66
            :|:..||..|..|:.||:                     |..|.:|:...:|:...|.||.|||.
Human    20 TGDPQLDTAIGQWLRWDKLQGRLAWCPGRRVEHDSCFLQNPKTKEQIENLLRNGMNKELRDRLCC 84

  Fly    67 RITYLTTGLRGVMRAGFDSLNDVVIIEVAQGICAYLVDAYPSIQKRQTQGVVVGYDGR------Y 125
            |:|:.|.|||..|.|||..:||:.:|:..||:..||...:...::|   |.|||||.|      .
Human    85 RMTFGTAGLRSAMGAGFCYINDLTVIQSTQGMYKYLERCFSDFKQR---GFVVGYDTRGQVTSSC 146

  Fly   126 NSKRFAQLIATVFLNNDFKVFLFTRMIPTPFIPFTVVTLQCLAGIVVTASHNVKEDNGIKVYWSN 190
            :|:|.|:|.|.|.|..|..|:||:|.:||||:|:.|..|:.:||:::|||||.|||||.||||..
Human   147 SSQRLAKLTAAVLLAKDVPVYLFSRYVPTPFVPYAVQKLKAVAGVMITASHNRKEDNGYKVYWET 211

  Fly   191 GAQAMAPHDQRIHDYMMNNLEPKPSSWETSLVLDHPLVEDPYRQIYPLFYEALKTLIPPIYLETN 255
            |||..:|||:.|...:...:||...||..:||...||..||.:.|...:.|.||.:.  .|.|.|
Human   212 GAQITSPHDKEILKCIEECVEPWNGSWNDNLVDTSPLKRDPLQDICRRYMEDLKKIC--FYRELN 274

  Fly   256 ECSQLRFIYTALHGVGYPFMREAFYQARLKPVIPVVEQKEADPEFPTLVKPNPEEGKEALKLAIK 320
            ..:.|:|::|:.||||:.:::.||.....||.|||.|||:.||:|.|:..||||||:..|:|:::
Human   275 SKTTLKFVHTSFHGVGHDYVQLAFKVFGFKPPIPVPEQKDPDPDFSTVKCPNPEEGESVLELSLR 339

  Fly   321 KADAEHCTLVLANDPDVDRLAVAELDPRGRWKLFNGNELGALLGWWALENYKTRTPKPA-VTNCI 384
            .|:.|:..:|||.|||.||||.|||...|.||:|.||||.||.|||..:.:|....:.| |.|..
Human   340 LAEKENARVVLATDPDADRLAAAELQENGCWKVFTGNELAALFGWWMFDCWKKNKSRNADVKNVY 404

  Fly   385 MIATLVSSRILAAMARVEGFIFVEGMPSFPWMAHRALELEKSGRTVLFAFEECFGYMFGMSLPDK 449
            |:||.|||:||.|:|..|||.|.|.:|.|.|:..|.::|.::|:.|||||||..|::.|.|:.||
Human   405 MLATTVSSKILKAIALKEGFHFEETLPGFKWIGSRIIDLLENGKEVLFAFEESIGFLCGTSVLDK 469

  Fly   450 DGIGAAMQLASMACYLRSTRNVTLIEKLREIYDTYGYHSSISSVYMADSPETITSVFDHLRNFTD 514
            ||:.||:.:|.||.|| .|.|:||.::|.::|:.||||.|.:|.::...|.||.|:|:.||||..
Human   470 DGVSAAVVVAEMASYL-ETMNITLKQQLVKVYEKYGYHISKTSYFLCYEPPTIKSIFERLRNFDS 533

  Fly   515 EEGYPKFILDEEFEVVHIRDLTIGLDTSFSDGKARMPVTPDAQLITFTFTNGYVVTLRSAPNDIK 579
            .:.||||.  ..|.::|:||:|.|.|:|..:.|:.:||:.::|:|||||.||.|.|||::..:.|
Human   534 PKEYPKFC--GTFAILHVRDVTTGYDSSQPNKKSVLPVSKNSQMITFTFQNGCVATLRTSGTEPK 596

  Fly   580 IKLNAEICGLPEEKQWEELHDKLNRMTNAVVEEFLQPEENGL 621
            ||..||:|..|::.....|.::|.::.:|::|.||||.:|||
Human   597 IKYYAEMCASPDQSDTALLEEELKKLIDALIENFLQPSKNGL 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgm2b	NP_610992.2	PTZ00150	26..621	CDD:240294	267/622 (43%)
PGM2L1	XP_011543255.1	PTZ00150	24..642	CDD:240294	269/623 (43%)