DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgm2b and SPCC1840.05c

DIOPT Version :9

Sequence 1:	NP_610992.2	Gene:	Pgm2b / 36649	FlyBaseID:	FBgn0033969	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_588504.1	Gene:	SPCC1840.05c / 2538920	PomBaseID:	SPCC1840.05c	Length:	587	Species:	Schizosaccharomyces pombe

Alignment Length:	605	Identity:	211/605 - (34%)
Similarity:	341/605 - (56%)	Gaps:	40/605 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IKNWVMWDRNEATLQQVTEAVRDQDWKALRVRLCHRITYLTTGLRGVMRAGFDSLNDVVIIEVAQ 96
            :..|...|::|.|..:|::.::.:|:..|:..:..||.:.|:|||..:.|||..:|.:.:|:.:|
pombe     9 VDEWFKLDQDETTRNEVSQLIKAEDYATLKQIMHPRIGFGTSGLRAEIGAGFARMNCLTVIQASQ 73

  Fly    97 GICAYLVDAYPSIQKRQTQGVVVGYDGRYNSKRFAQLIATVFLNNDFKVFLFTRMIPTPFIPFTV 161
            |...||:...||..|   .|||:|:|.|:.|..||:|.|.|||...||.:.|..::.||.:||.|
pombe    74 GFAEYLLQTVPSAAK---LGVVIGHDHRHKSNTFARLTAAVFLQKGFKTYFFDHLVHTPLVPFAV 135

  Fly   162 VTLQCLAGIVVTASHNVKEDNGIKVYWSNGAQAMAPHDQRIHDYMMNNLEPKPSSWETSLVLDHP 226
            .||...||:::|||||....||.||||.||...:.|||:.|...:..||  .|.:|:.:||.:|.
pombe   136 KTLGTAAGVMITASHNPAAYNGYKVYWGNGCAIIPPHDKGIAACIEKNL--TPITWDKNLVENHK 198

  Fly   227 LVEDPY-----RQIYPLFYEALKTLIPPIYLETN---ECSQLRFIYTALHGVGYPFMREAFYQ-A 282
            |.:..:     :..:...:|        .:.|.|   |...|:|:||.:||||.||:..|.:. .
pombe   199 LADRDFAVGLLKNYWSQLHE--------FHSENNFSLEMKSLKFVYTPIHGVGLPFVTSALHLFG 255

  Fly   283 RLKPVIPVVEQKEADPEFPTLVKPNPEEGKEALKLAIKKADAEHCTLVLANDPDVDRLAVAELDP 347
            ....:|.|..|...:|:|||:..||||| :.||.||.::|||...:.|||.|||.||.|.|| ..
pombe   256 EQGDMISVPLQDSPNPDFPTVKFPNPEE-EGALDLAYEQADANGISYVLATDPDADRFAFAE-KI 318

  Fly   348 RGRWKLFNGNELGALLGWWALENYKTRTPKPAVTNCIMIATLVSSRILAAMARVEGFIFVEGMPS 412
            .|.|:.|.|:|:|.:|.::..:.|| ...|| :.:..:::|.|||.::.:||:||||..||.:..
pombe   319 NGAWRRFTGDEVGCILAYFIFQEYK-NVGKP-IDDFYVLSTTVSSAMVKSMAKVEGFHHVETLTG 381

  Fly   413 FPWMAHRALELEKSGRTVLFAFEECFGYMFGMSLPDKDGIGAAMQLASMACYLRSTRNVTLIEKL 477
            |.|:.::||||||.|:.:..|:||..|||.|..:.||||:.|.:....:...|: .:|:::.|..
pombe   382 FKWLGNKALELEKQGKFIGLAYEEALGYMVGSIVRDKDGVNALITFLHLLKRLQ-LQNLSITEVF 445

  Fly   478 REIYDTYGYHSSISSVYMADSPETITSVFDHLRNFTDEEGYPKFILDEEFEVVHIRDLTIGLDTS 542
            .::...|||:::.:|.:::.....:.::.|.||::..:.|||..:..:  ::.::||||.|.|:|
pombe   446 EQMSKKYGYYTTQNSYFLSRDTPKLRALVDALRHYDTKSGYPATLGSK--KITNVRDLTTGYDSS 508

  Fly   543 FSDGKARMPVTPDAQLITFTFTNGYVV-TLRSAPNDIKIKLNAEICGLPEEKQWEELHDKLNRMT 606
            .:||||.:||:..:..:||...||.|: |:|::..:.|:|.  .||.     :...|.|.:...|
pombe   509 STDGKATLPVSKSSDNVTFELENGEVIMTIRTSGTEPKLKF--YICA-----RGHSLEDSIKNAT 566

  Fly   607 ---NAVVEEFLQPEENGLTD 623
               .|:..|:..|::|||.:
pombe   567 EVKQAIKSEWFHPQQNGLEE 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgm2b	NP_610992.2	PTZ00150	26..621	CDD:240294	209/601 (35%)
Pgm2b	NP_610992.2	PGM2	67..607	CDD:100092	198/552 (36%)
SPCC1840.05c	NP_588504.1	PTZ00150	1..587	CDD:240294	211/605 (35%)
SPCC1840.05c	NP_588504.1	PGM2	44..570	CDD:100092	198/552 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	145	1.000	Domainoid score	I1145
eggNOG	1	0.900	-	-		E1_COG1109
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6693
Inparanoid	1	1.050	422	1.000	Inparanoid score	I344
OMA	1	1.010	-	-		QHG53730
OrthoFinder	1	1.000	-	-		FOG0002126
OrthoInspector	1	1.000	-	-		otm47138
orthoMCL	1	0.900	-	-		OOG6_100912
Panther	1	1.100	-	-	O	PTHR45745
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1578
TreeFam	1	0.960	-	-
	13	12.830