DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spred and spred2b

DIOPT Version :9

Sequence 1:	NP_001260979.1	Gene:	Spred / 36643	FlyBaseID:	FBgn0020767	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_998399.1	Gene:	spred2b / 793290	ZFINID:	ZDB-GENE-040426-2342	Length:	413	Species:	Danio rerio

Alignment Length:	455	Identity:	162/455 - (35%)
Similarity:	219/455 - (48%)	Gaps:	82/455 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EGHESD--FLVTVRAQVMTRDESTEGWLPLAGGGLANVSIRKRARLSPLASGHDYIIYGQRISDQ 65
            |.|.:|  ::|.|:|.|||||:|:.|||...||||:.|.:.| ...:.|....|::|:|:|:.|:
Zfish     4 ETHPNDDSYIVRVKAVVMTRDDSSGGWLAQEGGGLSRVGVCK-VMPAELTGRSDFLIHGERLKDK 67

  Fly    66 SVILSCVINRDLKYYKVMPTFHHWRAGKQRNGLTFQTAADARAFDKGVLRAYNELIDGLAKSNPT 130
            .|||.|.:.:||.|.|..||||||:...::.|||||:.|||||||:||.:|..:|.:|...|:.|
Zfish    68 QVILECFVRKDLIYTKATPTFHHWKVDNKKCGLTFQSPADARAFDRGVRKALEDLTEGSTTSSST 132

  Fly   131 IICPPLTKYDSVGEDDVFMTLDLPVESESLQKIHSSPEGSEKSHKSVSNNSDSEKLP-------P 188
                 |.....:|:||||.|......:.|.:|.||:        :.|:.::..|..|       .
Zfish   133 -----LQNEAELGDDDVFTTATDSSSNSSQKKDHST--------QLVATSTFYEPHPHRCILQYR 184

  Fly   189 PPIHYISTDKTSATTSPPDAPPASAAPSPATAGQIAASENY----------------SYVTLT-- 235
            ||..|....|.|....|.: .......:|.....|...|:|                |||.::
Zfish   185 PPERYTLDQKFSRNLFPFE-DEEIVRINPRERWMITGYEDYRYAAVPDKFIQPEDSDSYVQISKN 248

  Fly   236 -AVHHDYNYPVVDQPVGAQVLNARRESISALKKRNALEAAQAMAAAQTAAGGGLACRDGGSGKPL 299
             .|.|||.||.|..|...|         ..||:                     .| .|||....
Zfish   249 DPVKHDYTYPYVPSPDFTQ---------CDLKR---------------------PC-GGGSTVVS 282

  Fly   300 HKPNVSDILK----KE--TRLRCRYCHELYSEDFNRRGACEYAPDAFRSGYECISGMGCARCMIY 358
            .:|. :.|||    ||  .|.||.||.::::.:.||||.|..|||..|:....:|.|.||..|:|
Zfish   283 TQPR-AFILKGKRRKEDGERSRCVYCRDMFNHEENRRGQCHDAPDPIRTCIHRVSFMWCADSMLY 346

  Fly   359 HCMSDAEGETAQHPCDCSASEAGCSKRWLGLAILSLFVPCLWCYPPLRACHLAGIHCGLCGGQHK 423
            |||||.||:.:. ||.|..||.....||..|..|::..|||.|||||..||..|:.||.|||:||
Zfish   347 HCMSDPEGDYSD-PCSCDTSEERFCLRWTALLGLAMLAPCLCCYPPLHGCHRCGVACGCCGGKHK 410

Fly 424 423
Zfish 411 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spred	NP_001260979.1	EVH1_SPRED-like	9..122	CDD:269978	54/112 (48%)
Spred	NP_001260979.1	Sprouty	315..413	CDD:282994	45/97 (46%)
spred2b	NP_998399.1	EVH1_SPRED-like	12..124	CDD:269978	54/112 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..163		14/45 (31%)
		Sprouty	302..397	CDD:282994	44/95 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575156
Domainoid	1	1.000	118	1.000	Domainoid score	I5814
eggNOG	1	0.900	-	-		E1_KOG4590
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H24918
Inparanoid	1	1.050	250	1.000	Inparanoid score	I3218
OMA	1	1.010	-	-		QHG45705
OrthoDB	1	1.010	-	-		D331423at33208
OrthoFinder	1	1.000	-	-		FOG0002271
OrthoInspector	1	1.000	-	-		otm24224
orthoMCL	1	0.900	-	-		OOG6_108509
Panther	1	1.100	-	-	O	PTHR11202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6309
SonicParanoid	1	1.000	-	-		X1007
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800