DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spred and spred3

DIOPT Version :9

Sequence 1:	NP_001260979.1	Gene:	Spred / 36643	FlyBaseID:	FBgn0020767	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_021323362.1	Gene:	spred3 / 568925	ZFINID:	ZDB-GENE-061207-31	Length:	540	Species:	Danio rerio

Alignment Length:	539	Identity:	155/539 - (28%)
Similarity:	219/539 - (40%)	Gaps:	164/539 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VTVRAQVMTRDESTEGWLPLAGGGLANVSIRKRARLSPLASGHDYIIYGQRISDQSVILSCVINR 75
            |.|||.|||||:|:.||:||.||||::|.|.| .|.|......:|:|.|:|:.|::.:|.|.|.:
Zfish    37 VRVRAVVMTRDDSSGGWVPLGGGGLSHVIICK-GRSSEGRGRREYVIRGERLRDRAPVLECAIQK 100

  Fly    76 DLKYYKVMPTFHHWRAGKQRNGLTFQTAADARAFDKGVLRAYNEL------------------ID 122
            .|.|.||.|.|||||..:::.|||||:.|||.:|::|:.....:|                  .|
Zfish   101 GLVYNKVNPIFHHWRVEERKFGLTFQSPADAISFERGLQSVLEKLDRGSDSPSSSTPEEGDTEDD 165

  Fly   123 GLA---------KSNPTIICPPLTKYDSVGEDDVFMTLDLPVE-------SESLQKIHSSPEGSE 171
            |.|         .|...::..|:|...|......|:.   |.|       :::..:||:.|...:
Zfish   166 GQASHTGSESSSNSRKEMLPKPITIVTSESSSTCFVR---PSEEFAYGNRTQTPAQIHTRPSQHQ 227

  Fly   172 KSHKSVSNNSDSEKLPPPPIHYISTDKTSATTSPPDAPPASAAPSPAT-------AGQIAASENY 229
            .:..:...|..|   ||||        ..|..:||.||||::..||.:       .|.:.:.:..
Zfish   228 LTQVTAVLNPPS---PPPP--------PPAPPTPPAAPPAASPLSPLSPTISLLEEGDLRSLDPC 281

  Fly   230 SYVTLTAVHHDYNYPVVDQPVGAQVLNARRESISAL----------------------------- 265
            ..:..|..:.||           :...|.|..:..|
Zfish   282 KDLWGTRGYEDY-----------RRAGATRTKVGGLTGGVVVGGGQDKSELCVVRFEKELAGVGT 335

  Fly   266 -------------KKRNA-------------------------------LEAAQAMAAAQT---A 283
                         .:||:                               :..:.|...::|   .
Zfish   336 TGCEVTVMLDTKGSQRNSSPTCMPNAVPGVPSASGSPQETGKSSPSPCCIHTSLATPRSRTRKRG 400

  Fly   284 AGGGLACR-DGGSGKPLHKPNVSDILKKETRLRCRYCHELYSEDFNRRGACEYAPDAFRSGYECI 347
            ||||.|.. |..|..|....:.|.        ||.||..::|...|.||.|..|||   ....|:
Zfish   401 AGGGEAISPDDDSSCPQGSSSCSS--------RCVYCRSVFSASENGRGRCRDAPD---PALHCL 454

  Fly   348 ---SGMGCARCMIYHCMSDAEGETAQHPCDCSASEAG-----CSKRWLGLAILSLFVPCLWCYPP 404
               :.:.||..::||||||:|||..: ||.|..|..|     |..||:.|..|||||||:.||.|
Zfish   455 RQWTCVWCAESLLYHCMSDSEGEFWE-PCSCEDSMGGRPHPLCCARWMALLALSLFVPCMCCYLP 518

  Fly   405 LRACHLAGIHCGLCGGQHK 423
            ||||...|..||.|||:||
Zfish   519 LRACLRCGERCGCCGGKHK 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spred	NP_001260979.1	EVH1_SPRED-like	9..122	CDD:269978	52/128 (41%)
Spred	NP_001260979.1	Sprouty	315..413	CDD:282994	47/105 (45%)
spred3	XP_021323362.1	EVH1_SPRED-like	37..147	CDD:269978	52/110 (47%)
spred3	XP_021323362.1	Sprouty	424..523	CDD:310077	46/110 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575160
Domainoid	1	1.000	118	1.000	Domainoid score	I5814
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	250	1.000	Inparanoid score	I3218
OMA	1	1.010	-	-		QHG45705
OrthoDB	1	1.010	-	-		D331423at33208
OrthoFinder	1	1.000	-	-		FOG0002271
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11202
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1007
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.010