DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spred and vaspb

DIOPT Version :9

Sequence 1:	NP_001260979.1	Gene:	Spred / 36643	FlyBaseID:	FBgn0020767	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_005173736.1	Gene:	vaspb / 550487	ZFINID:	ZDB-GENE-030131-7118	Length:	445	Species:	Danio rerio

Alignment Length:	392	Identity:	92/392 - (23%)
Similarity:	152/392 - (38%)	Gaps:	97/392 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RAQVMTRDESTEGWLPLAGGGLANVSIRKRARLSPLASGHDYIIYGQRI-SDQSVILSCVINRDL 77
            ||.||..|:.::.|:| ||.|....|   |.::....:.:.:.:.|::: :||.|:::|.|.:.|
Zfish    10 RATVMIYDDGSKKWVP-AGTGPQAFS---RVQIYHNPTNNAFRVVGRKMQTDQQVVINCPIVKGL 70

  Fly    78 KYYKVMPTFHHWRAGKQRNGLTFQTAADARAFDKGVLRAYNELI---DGLAKSNPTIICPPLTKY 139
            ||.:..|.||.||..:|..||.|.:..||..|..|::.|.:.|.   ||...:.|....|
Zfish    71 KYNQATPNFHQWRDARQVWGLNFGSKEDAALFANGMMHALDVLSSIPDGGYSARPVSNGP----- 130

  Fly   140 DSVGEDDVFMTLDLP-VESESLQKIHSSPEGSEKSHKSVSNNSDSEK-------------LPP-P 189
             |..|.:....|:.. :|.:..:::....:..|:..:........|:             :|| |
Zfish   131 -SPEELEQQRRLEQQRLEQQERERLERERQERERQERERQERERQERERQERERPVASVVIPPAP 194

  Fly   190 PIHYISTDKTSATTSPP---------------------DAPPASAAPSPATAGQ----------- 222
            |   ::.....|...||                     .|||..|.|.|::.|.
Zfish   195 P---LAPGGPPAPPGPPPPPGPPPSGPPPPPGPPPSGGGAPPPPAPPLPSSGGSDGGGGPGGGGG 256

  Fly   223 IAASENYSYVTLTAVHHDYNYPVVDQPVGAQVLNARRESISALKK---RNALEAAQAMAAAQTAA 284
            :||:  .:...|..|..|      |...|..|.:| ..|::|.|.   ||::    :|.:.....
Zfish   257 LAAA--LAAAKLRKVPKD------DAGGGGGVASA-AASVAAPKADSGRNSV----SMPSGGGGG 308

  Fly   285 GGGLACRDGGSGKPLHKPNVSDILKKETRLRCR------YCHELYSEDFNRRGACEYAPDAFRSG 343
            |||     ||.|..| ...:|.||.:..:...:      ...|..::|.:.:|     |..||..
Zfish   309 GGG-----GGGGGGL-MGEMSAILARRRKAADKGEKPPPKAEEPANDDSDTQG-----PGDFRRP 362

  Fly   344 YE 345
            :|
Zfish   363 WE 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spred	NP_001260979.1	EVH1_SPRED-like	9..122	CDD:269978	36/111 (32%)
Spred	NP_001260979.1	Sprouty	315..413	CDD:282994	7/37 (19%)
vaspb	XP_005173736.1	EVH1_Ena_VASP-like	5..114	CDD:269918	35/107 (33%)
vaspb	XP_005173736.1	VASP_tetra	411..441	CDD:285929
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810