DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spred and spred1

DIOPT Version :9

Sequence 1:	NP_001260979.1	Gene:	Spred / 36643	FlyBaseID:	FBgn0020767	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001008037.1	Gene:	spred1 / 493399	XenbaseID:	XB-GENE-482851	Length:	406	Species:	Xenopus tropicalis

Alignment Length:	456	Identity:	153/456 - (33%)
Similarity:	220/456 - (48%)	Gaps:	91/456 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EGHESDFLVTVRAQVMTRDESTEGWLPLAGGGLANVSIRKRARLSPLAS-GHDYIIYGQRISDQS 66
            |....|....|||.|||||:|:.|||.|.||||::|::.|  .|.|..| |.:::::|:|:.|::
Frog     4 EQEPDDSYARVRAVVMTRDDSSGGWLQLGGGGLSSVTVSK--TLQPGDSGGTEFLVHGERLRDKT 66

  Fly    67 VILSCVINRDLKYYKVMPTFHHWRAGKQRNGLTFQTAADARAFDKGVLRAYNELIDGLAKSNPTI 131
            |:|.||:.|||.|.||.|||||||.|.::.|||||:.|||||||:|:.||..:|..||..|
Frog    67 VVLECVLRRDLVYNKVTPTFHHWRIGDKKFGLTFQSPADARAFDRGIRRAIEDLSQGLPAS---- 127

  Fly   132 IC----------PPLTKYD--SVGEDDVFMTLDLPVESESLQK---IHSSPEGSEKSHKSVSNNS 181
             |          |.:.|.|  |...:|.|...| .:.:|.|.:   |..||..:....::..:|
Frog   128 -CHGESETSEDGPQVNKEDHYSTHNNDHFFRSD-SIPTEELYRTSVIRPSPFENLNPRRAYIHN- 189

  Fly   182 DSEKLPPPPIHYIS--TDKTSATTSPPDAPPASAAPSPATAGQIAASENYSYVTLTAVHHDYNYP 244
               ::|..||.::|  .:......:|.|                         .:...:.||.:|
Frog   190 ---QVPLKPIRHVSFQDEDEIVRINPRD-------------------------MIIRRYADYRHP 226

  Fly   245 VV-------DQPVGAQVLNARRESISALKKRNALEAAQAMAAAQTAAGGGLACRDG-GSGKPLH- 300
            .:       ::|          |.::...|.::.:.:...:.|..        ||. ...||:.
Frog   227 DIFRNDVDREEP----------EDVTFFTKTDSKKPSYLYSPANG--------RDSLKEQKPVEV 273

  Fly   301 -KPNVSDILKKETRLR-------CRYCHELYSEDFNRRGACEYAPDAFRSGYECISGMGCARCMI 357
             |...:..|||....:       |.||.|.::.:.|.||.|:.|||..:.....:|.|.||..|:
Frog   274 CKIQPTSSLKKSKGKKEDGEHSSCVYCQERFNHEENGRGKCQDAPDPIQRCIYQVSCMLCAESML 338

  Fly   358 YHCMSDAEGETAQHPCDCSASEAGCSKRWLGLAILSLFVPCLWCYPPLRACHLAGIHCGLCGGQH 422
            ||||||:||:.:. ||.|.||:.....|||.|..||...||:.||.||||||..|..||.|||:|
Frog   339 YHCMSDSEGDYSD-PCSCDASDENLCLRWLALITLSFIAPCMCCYLPLRACHHCGEMCGCCGGKH 402

  Fly   423 K 423
            |
Frog   403 K 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spred	NP_001260979.1	EVH1_SPRED-like	9..122	CDD:269978	60/113 (53%)
Spred	NP_001260979.1	Sprouty	315..413	CDD:282994	45/104 (43%)
spred1	NP_001008037.1	EVH1_SPRED-like	10..122	CDD:269978	60/113 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..154		7/34 (21%)
		Sprouty	297..390	CDD:368340	44/93 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5832
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	251	1.000	Inparanoid score	I3139
OMA	1	1.010	-	-		QHG45705
OrthoDB	1	1.010	-	-		D331423at33208
OrthoFinder	1	1.000	-	-		FOG0002271
OrthoInspector	1	1.000	-	-		otm49455
Panther	1	1.100	-	-	LDO	PTHR11202
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1007
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080