DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spred and evlb

DIOPT Version :9

Sequence 1:	NP_001260979.1	Gene:	Spred / 36643	FlyBaseID:	FBgn0020767	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_021324059.1	Gene:	evlb / 402929	ZFINID:	ZDB-GENE-040426-1804	Length:	403	Species:	Danio rerio

Alignment Length:	347	Identity:	80/347 - (23%)
Similarity:	136/347 - (39%)	Gaps:	87/347 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RAQVMTRDESTEGWLPLAGG--GLANVSIRKRARLSPLASGHDYIIYGQRISDQSVILSCVINRD 76
            ||.||..|::::.|:|:..|  |.:.::|...      .:.:.:.:.|.::.||.|:::..|.:.
Zfish    36 RASVMVYDDTSKKWVPIKPGQQGFSRINIYHN------TTSNTFRVVGVKLQDQQVVINYSIVKG 94

  Fly    77 LKYYKVMPTFHHWRAGKQRNGLTFQTAADARAFDKGVLRAYNEL--------IDGLAKSNPTIIC 133
            |||.:..||||.||..:|..||.|.:..:|..|...:|.|.|.|        :...|::.|:
Zfish    95 LKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNVLSSQDGGPAVQRQAQNGPS--- 156

  Fly   134 PPLTKYDSVGEDDVFMTLDLPVESESLQ----KIH------SSPEGSE-KSHKSVSNNSDSEKLP 187
                            |.:|.|:...::    :.|      ||..||. :.|.:|.:.:....:|
Zfish   157 ----------------TEELEVQRRQMEMQQMQAHIERERRSSNSGSPFQGHPAVLSVAPPSVVP 205

  Fly   188 PPPIHYIST-DKTSATTSPPDAPPASAA------PSPATAGQIAASENYSYVTLTAVHHDYNYP- 244
            ||    :|. ........||..||..:|      |.|...|        .|....:...|.:.|
Zfish   206 PP----LSLGGPCPPPPPPPPVPPLPSAGAPPPPPPPLPVG--------GYGAHGSAQDDSSAPT 258

  Fly   245 -VVDQPVGAQVLNARR-ESISALKKRNALEAAQAMAAAQTAAGGGLACRDGGSGKPLHKPNVSDI 307
             :.....||::...:| |..||...:|        .|.:|:         ||||..:.:.|.  :
Zfish   259 GLAAMIAGAKLRRVQRPEDNSASGAKN--------DANRTS---------GGSGGLMEEMNA--L 304

  Fly   308 LKKETRLRCRYCHELYSEDFNR 329
            |.:..:.......|..::|.||
Zfish   305 LARRRKAADEKKDESQNDDLNR 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spred	NP_001260979.1	EVH1_SPRED-like	9..122	CDD:269978	34/117 (29%)
Spred	NP_001260979.1	Sprouty	315..413	CDD:282994	4/15 (27%)
evlb	XP_021324059.1	EVH1_Ena_VASP-like	31..139	CDD:269918	33/108 (31%)
evlb	XP_021324059.1	VASP_tetra	366..400	CDD:312347
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575151
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840