DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spred and SPRED3

DIOPT Version :9

Sequence 1:	NP_001260979.1	Gene:	Spred / 36643	FlyBaseID:	FBgn0020767	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001035987.1	Gene:	SPRED3 / 399473	HGNCID:	31041	Length:	410	Species:	Homo sapiens

Alignment Length:	457	Identity:	142/457 - (31%)
Similarity:	188/457 - (41%)	Gaps:	94/457 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LVTVRAQVMTRDESTEGWLPLAGGGLANVSIRKRARLSP---LASGHDYIIYGQRISDQSVILSC 71
            :|.|||.||.||:|:.||||:.||||:.||:.:.....|   ...|| |:|:|:|:.||...|.|
Human     1 MVRVRAVVMARDDSSGGWLPVGGGGLSQVSVCRVRGARPEGGARQGH-YVIHGERLRDQKTTLEC 64

  Fly    72 VINRDLKYYKVMPTFHHWRAGKQRNGLTFQTAADARAFDKGVLRAYNELIDGLAKSNPTIICPPL 136
            .:...|.|.||.|.||||..|..:.|||||:.|:|..|.|.:|.|...|  |.....|:
Human    65 TLKPGLVYNKVNPIFHHWSLGDCKFGLTFQSPAEADEFQKSLLAALAAL--GRGSLTPS------ 121

  Fly   137 TKYDSVGEDDVFMTLDLPVESESLQKIHSSPEGSEKSHKSVSNNSDSEKLPPPPIHYISTDKTSA 201
                                               .|..|.|.:.|:.:.|.|...::.:|.:|:
Human   122 -----------------------------------SSSSSSSPSQDTAETPCPLTSHVDSDSSSS 151

  Fly   202 TTSPPDAPPASAAP----------SPATAGQIAASENYSYVTL---TAV---------------- 237
            .:.....|.|:|||          .|.|..|...|...||..|   |.:
Human   152 HSRQETPPSAAAAPIITMESASGFGPTTPPQRRRSSAQSYPPLLPFTGIPEPSEPLAGAGGLGWG 216

  Fly   238 ---HHDYNYPVVDQPVGAQVLNARRESISALKKRNALEAAQAMAAAQTAAGGGLACRDGGSGKPL 299
               :.||.......|:.......|.....||:.. ||....|:.|..|.     |.......:|.
Human   217 GRGYEDYRRSGPPAPLALSTCVVRFAKTGALRGA-ALGPPAALPAPLTE-----AAPPAPPARPP 275

  Fly   300 HKPNVSDILKK-----ETRLRCRYCHELYSEDFNRRGA-CEYAPDAFRSGYECISGMGCARCMIY 358
            ..|..|....|     |...||.:|..|:....:.||. |..|||..|.....:|.:.||..::|
Human   276 PGPGPSSAPAKASPEAEEAARCVHCRALFRRRADGRGGRCAEAPDPGRLLVRRLSCLWCAESLLY 340

  Fly   359 HCMSDAEGETAQHPCDCSASEAGCSKRWLGLAILSLFVPCLWCYPPLRACHLAGIHCGL--CGGQ 421
            ||:|||||:.:. ||.|.......:.||..||.|||.||||.||.||||||.....||.  |||:
Human   341 HCLSDAEGDFSD-PCACEPGHPRPAARWAALAALSLAVPCLCCYAPLRACHWVAARCGCAGCGGR 404

  Fly   422 HK 423
            |:
Human   405 HE 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spred	NP_001260979.1	EVH1_SPRED-like	9..122	CDD:269978	52/114 (46%)
Spred	NP_001260979.1	Sprouty	315..413	CDD:282994	44/98 (45%)
SPRED3	NP_001035987.1	EVH1_SPRED-like	2..105	CDD:269978	48/103 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..210		22/133 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..288		7/34 (21%)
		Sprouty	296..400	CDD:398746	46/104 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142466
Domainoid	1	1.000	109	1.000	Domainoid score	I6342
eggNOG	1	0.900	-	-		E1_KOG4590
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3401
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45705
OrthoDB	1	1.010	-	-		D331423at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11202
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1007
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	9.000