DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spred and Vasp

DIOPT Version :9

Sequence 1:	NP_001260979.1	Gene:	Spred / 36643	FlyBaseID:	FBgn0020767	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_038937655.1	Gene:	Vasp / 361517	RGDID:	1311542	Length:	378	Species:	Rattus norvegicus

Alignment Length:	322	Identity:	78/322 - (24%)
Similarity:	129/322 - (40%)	Gaps:	59/322 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RAQVMTRDESTEGWLPLAGGGLANVSIRKRARLSPLASGHDYIIYGQRIS-DQSVILSCVINRDL 77
            ||.||..|:|.:.||| ||.|....|   |.::....:.:.:.:.|:::. ||.|:::|.|.|.:
  Rat    12 RATVMLYDDSNKRWLP-AGTGPQAFS---RVQIYHNPTANSFRVVGRKLQPDQQVVINCAIIRGV 72

  Fly    78 KYYKVMPTFHHWRAGKQRNGLTFQTAADARAFDKGVLRAYNELIDGLAKSNPTIICPPLTKYDSV 142
            ||.:..|.||.||..:|..||.|.:..||..|..|:..|...|..|   ..|....||
  Rat    73 KYNQATPIFHQWRDARQVWGLNFGSKEDAAQFAIGMANALEALEGG---GPPPAPAPP------- 127

  Fly   143 GEDDVFMTLDLPVESESLQKIHSSPEGSEKSHKSVSNNSDSEKLP---------------PPPIH 192
                .:.|.:.| ..|.|::....||..|   :.|||.......|               |||..
  Rat   128 ----AWSTQNGP-SPEELEQQKRQPEHLE---RRVSNAGGPPAPPAGGPPPPPGPPPPPGPPPPP 184

  Fly   193 YISTDKTSAT-----TSPPDAPPASAAPSPATAGQ----IAASENYSYVTLTAVHHDYNYPVVDQ 248
            .:.....|..     .:||.|||...|..|::.|.    :||:...:.:...:...:.:    ..
  Rat   185 GLPPSGVSGAGHGTGVAPPPAPPLPTAQGPSSGGSGAPGLAAAIAGAKLRKVSKQEEAS----GG 245

  Fly   249 PVGAQVLNAR------RESISAL--KKRNALEAAQAMAAAQTAAGGGLACRDGGSGKPLHKP 302
            |:..:..|:|      .|.::|:  ::|.|.:..:.....::|:......|.....:|:.:|
  Rat   246 PLAPKAENSRGTGGGLMEEMNAMLARRRKATQVGEKPPKDESASQEESEARIPAQSEPVRRP 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spred	NP_001260979.1	EVH1_SPRED-like	9..122	CDD:269978	38/108 (35%)
Spred	NP_001260979.1	Sprouty	315..413	CDD:282994
Vasp	XP_038937655.1	EVH1_Ena_VASP-like	7..115	CDD:269918	37/106 (35%)
		WH2_hVASP-like	217..243	CDD:409225	3/25 (12%)
		VASP_tetra	342..375	CDD:400912
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810