Protein Alignment Spred and Spred2

DIOPT Version :9

• Sequence 1: NP_001260979.1
• Gene: Spred / 36643
• FlyBaseID: FBgn0020767
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_006514519.1
• Gene: Spred2 / 114716
• MGIID: 2150019
• Length: 427
• Species: Mus musculus
• Alignment Length: 457
• Identity: 148/457 - (32%)
• Similarity: 215/457 - (47%)
• Gaps: 96/457 - (21%)

  Fly     6 ESD-FLVTVRAQVMTRDESTEGWLPLAGGGLANVSIRKRARLSPLASGHD-YIIYGQRISDQSVI 68
            :|| ::|.|:|.|||||:|:.||.|..|||::.|.:.|  .:.|..:|.. ::|:|:|..|:.|:
Mouse    25 DSDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCK--VMHPEGNGRSGFLIHGERQKDKLVV 87

  Fly    69 LSCVINRDLKYYKVMPTFHHWRAGKQRNGLTFQTAADARAFDKGVLRAYNELIDGLAKSNPTIIC 133
            |.|.:.:||.|.|..||||||:...::.|||||:.|||||||:||.:|..:||:|...|:.|
Mouse    88 LECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIEDLIEGSTTSSST--- 149

  Fly   134 PPLTKYDSVGEDDVFMTLDLPVESESLQKIHSSPEGSEKSHKSVSNNSDSE-----KLPPPPIHY 193
              |.....:|:||||.|   ..:|.|     :|.:..|.:.:::|:.:..|     .|.|.|:.:
Mouse   150 --LHNEAELGDDDVFTT---ATDSSS-----NSSQKREPTTRTISSPTSCEHRKIYTLDPYPMDH 204

  Fly   194 ISTDKTSATTSP----PDAPPASAAPSPATAGQIAASENY-----------------SYVTLT-- 235
            ...|:....:.|    |:........:|.....:...|:|                 |||...
Mouse   205 YHPDQRLPRSYPQVTFPEDDEEIVRINPREKIWMTGYEDYRHAPVRGKYLDTTEDADSYVRFAKG 269

  Fly   236 -AVHHDYNYPVVD--------QPVGAQVLNARRESISALKKRNALEAAQAMAAAQTAAGGGLACR 291
             ...|:|.||.||        .|.|:.:......:.|..:|.|.
Mouse   270 EVPKHEYTYPYVDSSDFGFGEDPKGSVIKTQPPRAKSRRRKENG--------------------- 313

  Fly   292 DGGSGKPLHKPNVSDILKKETRLRCRYCHELYSEDFNRRGACEYAPDAFRSGYECISGMGCARCM 356
                                .|.||.||.::::.:.||||.|:.||||.|:....:|.|.||..|
Mouse   314 --------------------ERSRCVYCRDMFNHEENRRGHCQDAPDAVRTCIRRVSCMWCADSM 358

  Fly   357 IYHCMSDAEGETAQHPCDCSASEAGCSKRWLGLAILSLFVPCLWCYPPLRACHLAGIHCGLCGGQ 421
            :||||||.||:... ||.|..|:.....||:.|..||...||:.||.||||||..|:.|..|||:
Mouse   359 LYHCMSDPEGDYTD-PCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACHRCGVMCRCCGGK 422

  Fly   422 HK 423
            ||
Mouse   423 HK 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spred	NP_001260979.1	EVH1_SPRED-like	9..122	CDD:269978	52/113 (46%)
		Sprouty	315..413	CDD:282994	46/97 (47%)
Spred2	XP_006514519.1	EVH1_SPRED-like	29..141	CDD:269978	52/113 (46%)
		Sprouty	316..414	CDD:368340	46/98 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832312
Domainoid	1	1.000	113	1.000	Domainoid score	I6113
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H24918
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3389
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45705
OrthoDB	1	1.010	-	-		D331423at33208
OrthoFinder	1	1.000	-	-		FOG0002271
OrthoInspector	1	1.000	-	-		otm44280
orthoMCL	1	0.900	-	-		OOG6_108509
Panther	1	1.100	-	-	O	PTHR11202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6309
SonicParanoid	1	1.000	-	-		X1007
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940