DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spred and Spred3

DIOPT Version :9

Sequence 1:	NP_001260979.1	Gene:	Spred / 36643	FlyBaseID:	FBgn0020767	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_891557.3	Gene:	Spred3 / 101809	MGIID:	2142186	Length:	408	Species:	Mus musculus

Alignment Length:	466	Identity:	150/466 - (32%)
Similarity:	198/466 - (42%)	Gaps:	114/466 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LVTVRAQVMTRDESTEGWLPLAGGGLANVSIRKRARLSP---LASGHDYIIYGQRISDQSVILSC 71
            :|.|||.||.||:|:.||||:.||||:.||:.:.....|   ...|| |:|:|:|:.||...|.|
Mouse     1 MVRVRAVVMARDDSSGGWLPVGGGGLSQVSVCRVRGARPEGGARQGH-YVIHGERLRDQKTTLEC 64

  Fly    72 VINRDLKYYKVMPTFHHWRAGKQRNGLTFQTAADARAFDKGVLRAYNELIDGLAKSNPTIICPPL 136
            .:...|.|.||.|.||||..|..:.|||||:.|:|..|.|.:|.|...|..|           .|
Mouse    65 TLRPGLVYNKVNPIFHHWSLGDCKFGLTFQSPAEADEFQKSLLAALAALSRG-----------SL 118

  Fly   137 TKYDSVGEDDVFMTLDLPVESESLQKIHSSPEGSEKSHKSVSNNSDSEKLPPPPIHYISTDKTSA 201
            |                |..|.|    .|||            :.|:.:.|.|...::.:|.:|:
Mouse   119 T----------------PSSSSS----SSSP------------SQDTAETPCPLTSHVDSDSSSS 151

  Fly   202 TT---SPPDAPPA---SAAPSP-ATAGQIAASENYSYVTLTAVHHDYNYPVVDQP------VGAQ 253
            .:   :||.||.|   |||..| ||..|...|...||..|..      :..:.:|      .|:|
Mouse   152 HSRQETPPTAPIATVESAAAFPLATPPQRRRSSAQSYPPLLP------FTGIPEPSESLAGAGSQ 210

  Fly   254 VLNAR-----RES------------ISALKKRNAL----------------EAAQAMAAAQTAAG 285
            ...:|     |.|            :....|..||                |||.....|:...|
Mouse   211 GWGSRGYEDYRRSGPPPPPLALSTCVVRFAKTGALRGAALGPPVSLPAPLTEAAPPAPPARPPPG 275

  Fly   286 GGLACRDGGSGKPLHKPNVSDILKKETRLRCRYCHELYSEDFNRRGA-CEYAPDAFRSGYECISG 349
            .|          |...|..:. .:.|...||.:|..|:....:.||. |..|||..|.....:|.
Mouse   276 PG----------PTPAPAKAS-PEAEEAARCVHCRALFRRRADGRGGRCAEAPDPGRLLVRRLSC 329

  Fly   350 MGCARCMIYHCMSDAEGETAQHPCDCSASEAGCSKRWLGLAILSLFVPCLWCYPPLRACHLAGIH 414
            :.||..::|||:|||||:.:. ||.|.......:.||..||.|||.||||.||.||||||.....
Mouse   330 LWCAESLLYHCLSDAEGDFSD-PCACEPGHPRPAARWAALAALSLAVPCLCCYAPLRACHWVAAR 393

  Fly   415 CGL--CGGQHK 423
            ||.  |||:|:
Mouse   394 CGCAGCGGRHE 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spred	NP_001260979.1	EVH1_SPRED-like	9..122	CDD:269978	52/114 (46%)
Spred	NP_001260979.1	Sprouty	315..413	CDD:282994	44/98 (45%)
Spred3	NP_891557.3	EVH1_SPRED-like	2..105	CDD:269978	48/103 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..226		35/145 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..286		8/39 (21%)
		Sprouty	294..391	CDD:368340	44/97 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832314
Domainoid	1	1.000	113	1.000	Domainoid score	I6113
eggNOG	1	0.900	-	-		E1_KOG4590
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3389
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45705
OrthoDB	1	1.010	-	-		D331423at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11202
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1007
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.960