Protein Alignment Spred and Spred3

DIOPT Version :10

• Sequence 1: NP_001260979.1
• Gene: Spred / 36643
• FlyBaseID: FBgn0020767
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_891557.3
• Gene: Spred3 / 101809
• MGIID: 2142186
• Length: 408
• Species: Mus musculus
• Alignment Length: 466
• Identity: 150/466 - (32%)
• Similarity: 198/466 - (42%)
• Gaps: 114/466 - (24%)

  Fly    10 LVTVRAQVMTRDESTEGWLPLAGGGLANVSIRKRARLSP---LASGHDYIIYGQRISDQSVILSC 71
            :|.|||.||.||:|:.||||:.||||:.||:.:.....|   ...|| |:|:|:|:.||...|.|
Mouse     1 MVRVRAVVMARDDSSGGWLPVGGGGLSQVSVCRVRGARPEGGARQGH-YVIHGERLRDQKTTLEC 64

  Fly    72 VINRDLKYYKVMPTFHHWRAGKQRNGLTFQTAADARAFDKGVLRAYNELIDGLAKSNPTIICPPL 136
            .:...|.|.||.|.||||..|..:.|||||:.|:|..|.|.:|.|...|..|           .|
Mouse    65 TLRPGLVYNKVNPIFHHWSLGDCKFGLTFQSPAEADEFQKSLLAALAALSRG-----------SL 118

  Fly   137 TKYDSVGEDDVFMTLDLPVESESLQKIHSSPEGSEKSHKSVSNNSDSEKLPPPPIHYISTDKTSA 201
            |                |..|.|    .|||            :.|:.:.|.|...::.:|.:|:
Mouse   119 T----------------PSSSSS----SSSP------------SQDTAETPCPLTSHVDSDSSSS 151

  Fly   202 TT---SPPDAPPA---SAAPSP-ATAGQIAASENYSYVTLTAVHHDYNYPVVDQP------VGAQ 253
            .:   :||.||.|   |||..| ||..|...|...||..|..      :..:.:|      .|:|
Mouse   152 HSRQETPPTAPIATVESAAAFPLATPPQRRRSSAQSYPPLLP------FTGIPEPSESLAGAGSQ 210

  Fly   254 VLNAR-----RES------------ISALKKRNAL----------------EAAQAMAAAQTAAG 285
            ...:|     |.|            :....|..||                |||.....|:...|
Mouse   211 GWGSRGYEDYRRSGPPPPPLALSTCVVRFAKTGALRGAALGPPVSLPAPLTEAAPPAPPARPPPG 275

  Fly   286 GGLACRDGGSGKPLHKPNVSDILKKETRLRCRYCHELYSEDFNRRGA-CEYAPDAFRSGYECISG 349
            .|          |...|..:. .:.|...||.:|..|:....:.||. |..|||..|.....:|.
Mouse   276 PG----------PTPAPAKAS-PEAEEAARCVHCRALFRRRADGRGGRCAEAPDPGRLLVRRLSC 329

  Fly   350 MGCARCMIYHCMSDAEGETAQHPCDCSASEAGCSKRWLGLAILSLFVPCLWCYPPLRACHLAGIH 414
            :.||..::|||:|||||:.:. ||.|.......:.||..||.|||.||||.||.||||||.....
Mouse   330 LWCAESLLYHCLSDAEGDFSD-PCACEPGHPRPAARWAALAALSLAVPCLCCYAPLRACHWVAAR 393

  Fly   415 CGL--CGGQHK 423
            ||.  |||:|:
Mouse   394 CGCAGCGGRHE 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spred	NP_001260979.1	EVH1_SPRED-like	9..122	CDD:269978	52/114 (46%)
		Sprouty	313..419	CDD:461589	46/108 (43%)
Spred3	NP_891557.3	EVH1_SPRED-like	2..105	CDD:269978	48/103 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..226		35/145 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..286		8/39 (21%)
		Sprouty	294..398	CDD:461589	46/104 (44%)