DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spred and spred3

DIOPT Version :9

Sequence 1:	NP_001260979.1	Gene:	Spred / 36643	FlyBaseID:	FBgn0020767	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_002939298.2	Gene:	spred3 / 100496277	XenbaseID:	XB-GENE-487918	Length:	424	Species:	Xenopus tropicalis

Alignment Length:	444	Identity:	148/444 - (33%)
Similarity:	222/444 - (50%)	Gaps:	50/444 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ESDFLVTVRAQVMTRDESTEGWLPLAGGGLANVSIRKRARLSPLASGHDYIIYGQRISDQSVILS 70
            :.|::|.|||.||.||:|:.||:|:.||||::|.|.| .|....:...||:|.|:|:.||:.||.
Frog     2 DRDYIVRVRAVVMCRDDSSGGWVPMGGGGLSHVMICK-VRRPETSHQRDYLIRGERLRDQTTILE 65

  Fly    71 CVINRDLKYYKVMPTFHHWRAGKQRNGLTFQTAADARAFDKGVLRAYNELIDG-LAKSNPTIICP 134
            ||:.:.|.|.|..|.||||:..:.:.|||||:.|||..|::.|..|..||.:| |:.|:.:....
Frog    66 CVLKKGLVYNKANPIFHHWKVEESKFGLTFQSPADAVTFERSVQAAMEELAEGSLSHSSSSSSSS 130

  Fly   135 PLTKYDSVGEDDVFMTLDLPVESESLQKIHSSPEGSEKSHKSVSNNSDSEKLPPPPIHYISTDKT 199
            ..|:.::...:|.     ||:.::|....:|..|...|....|::.|.|......|:    ::..
Frog   131 SSTREEAEALEDA-----LPLHTDSESSSNSRKEMLPKHITIVTSESSSSCYVRSPV----SEDF 186

  Fly   200 SATTSPPDAPPASAAP-------------SPATAGQIAASENYSYVTLTAVHHDYNYPVV---DQ 248
            ..:|.|..:|...:.|             |......:..|:.|         .||....:   :|
Frog   187 GFSTGPSVSPTTQSQPLQRLSFHDEEELESINPCKDLWVSKGY---------EDYRRAALQRTEQ 242

  Fly   249 PVGAQVLNARRESISALKKRNALEAAQAMAAAQTAAGGGL-------ACRDGGSGKPLHKPNVSD 306
            |.....::.::.|.|..|:|:   ...|.....|.:.|.|       :||..|:..|..|.:.:.
Frog   243 PKSDLRVHFQKASGSKAKERH---FPGATGTTLTESEGPLKDPSASPSCRIHGTPSPKSKEHANV 304

  Fly   307 ILKKET-RLRCRYCHELYSEDFNRRGACEYAPDAF-RSGYECISGMGCARCMIYHCMSDAEGETA 369
            :.:.:| ..||.||.::::.:.|.||.|:.|||.. |..|: :|.|.||..::||||||:|||.:
Frog   305 LGEDDTATARCVYCRDVFTSEENGRGQCQDAPDPIGRCVYQ-LSCMWCAESLLYHCMSDSEGEYS 368

  Fly   370 QHPCDCSASEAGCSKRWLGLAILSLFVPCLWCYPPLRACHLAGIHCGLCGGQHK 423
            . ||.|.........||..|..|||.|||:.||.||||||..|.|||.|||:||
Frog   369 D-PCSCDPGHPHFCVRWAALVALSLVVPCMCCYLPLRACHWCGEHCGCCGGKHK 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spred	NP_001260979.1	EVH1_SPRED-like	9..122	CDD:269978	52/112 (46%)
Spred	NP_001260979.1	Sprouty	315..413	CDD:282994	46/98 (47%)
spred3	XP_002939298.2	EVH1_SPRED-like	5..117	CDD:269978	52/112 (46%)
spred3	XP_002939298.2	Sprouty	314..408	CDD:368340	45/95 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5832
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	251	1.000	Inparanoid score	I3139
OMA	1	1.010	-	-		QHG45705
OrthoDB	1	1.010	-	-		D331423at33208
OrthoFinder	1	1.000	-	-		FOG0002271
OrthoInspector	1	1.000	-	-		otm49455
Panther	1	1.100	-	-	O	PTHR11202
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1007
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080