DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn6 and Psmd11

DIOPT Version :9

Sequence 1:	NP_725412.2	Gene:	Rpn6 / 36638	FlyBaseID:	FBgn0028689	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_848731.2	Gene:	Psmd11 / 69077	MGIID:	1916327	Length:	422	Species:	Mus musculus

Alignment Length:	424	Identity:	288/424 - (67%)
Similarity:	348/424 - (82%)	Gaps:	4/424 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 MAGATL--FERAQALSSVNREEQDSSLLNKLVRDQEGAENDEERIRIKEQGILQQGELYKQEGKA 80
            ||.|.:  |:|||:|.|.:||.....|.:.:.||.:  |||||.:::|||.||:.|.|..:.|:|
Mouse     1 MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQ--ENDEEAVQVKEQSILELGSLLAKTGQA 63

  Fly    81 KELADLIKVTRPFLSSISKAKAAKLVRSLVDMFLDMDAGTGIEVQLCKDCIEWAKQEKRTFLRQS 145
            .||..|:|..||||:||||||||:|||||:|:||||:|.||.||:||.:||||||.||||||||:
Mouse    64 AELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSEKRTFLRQA 128

  Fly   146 LEARLIALYFDTALYTEALALGAQLLRELKKLDDKNLLVEVQLLESKTYHALSNLPKARAALTSA 210
            |||||::|||||..|.|||.||:||||||||:|||.|||||||||||||||||||||||||||||
Mouse   129 LEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSA 193

  Fly   211 RTTANAIYCPPKVQGALDLQSGILHAADERDFKTAFSYFYEAFEGFDSVDSVKALTSLKYMLLCK 275
            ||||||||||||:|..||:||||:|||:|:|:|||:|||||||||:||:||.||:||||||||||
Mouse   194 RTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCK 258

  Fly   276 IMLGQSDDVNQLVSGKLAITYSGRDIDAMKSVAEASHKRSLADFQAALKEYKKELAEDVIVQAHL 340
            |||...:||..|||||||:.|:||..:|:|.||:||..||||||:.||.:|:.||.:|.|:..||
Mouse   259 IMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTHL 323

  Fly   341 GTLYDTMLEQNLCRIIEPYSRVQVAHVAESIQLPMPQVEKKLSQMILDKKFSGILDQGEGVLIVF 405
            ..|||.:|||||.|:|||:||||:.|::..|:|....||:|||||||||||.|||||||||||:|
Mouse   324 AKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLIIF 388

  Fly   406 EETPVDKTYERVLETIQSMGKVVDTLYQKAKKLS 439
            :|.|||||||..|||||:|.||||:||.|||||:
Mouse   389 DEPPVDKTYEAALETIQNMSKVVDSLYSKAKKLT 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn6	NP_725412.2	RPN6	18..438	CDD:227488	286/421 (68%)
Rpn6	NP_725412.2	PCI	302..406	CDD:279707	64/103 (62%)
Psmd11	NP_848731.2	RPN6	17..421	CDD:227488	278/405 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837337
Domainoid	1	1.000	248	1.000	Domainoid score	I2146
eggNOG	1	0.900	-	-		E1_COG5159
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2108
Inparanoid	1	1.050	563	1.000	Inparanoid score	I1079
Isobase	1	0.950	-	0	Normalized mean entropy	S570
OMA	1	1.010	-	-		QHG53498
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003528
OrthoInspector	1	1.000	-	-		oto93011
orthoMCL	1	0.900	-	-		OOG6_101896
Panther	1	1.100	-	-	LDO	PTHR10678
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1205
SonicParanoid	1	1.000	-	-		X2408
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740