DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rpn6 and PSMD11

DIOPT Version :9

Sequence 1:	NP_725412.2	Gene:	Rpn6 / 36638	FlyBaseID:	FBgn0028689	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001257411.1	Gene:	PSMD11 / 5717	HGNCID:	9556	Length:	422	Species:	Homo sapiens

Alignment Length:	424	Identity:	288/424 - (67%)
Similarity:	348/424 - (82%)	Gaps:	4/424 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 MAGATL--FERAQALSSVNREEQDSSLLNKLVRDQEGAENDEERIRIKEQGILQQGELYKQEGKA 80
            ||.|.:  |:|||:|.|.:||.....|.:.:.||.:  |||||.:::|||.||:.|.|..:.|:|
Human     1 MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQ--ENDEEAVQVKEQSILELGSLLAKTGQA 63

  Fly    81 KELADLIKVTRPFLSSISKAKAAKLVRSLVDMFLDMDAGTGIEVQLCKDCIEWAKQEKRTFLRQS 145
            .||..|:|..||||:||||||||:|||||:|:||||:|.||.||:||.:||||||.||||||||:
Human    64 AELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSEKRTFLRQA 128

  Fly   146 LEARLIALYFDTALYTEALALGAQLLRELKKLDDKNLLVEVQLLESKTYHALSNLPKARAALTSA 210
            |||||::|||||..|.|||.||:||||||||:|||.|||||||||||||||||||||||||||||
Human   129 LEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSA 193

  Fly   211 RTTANAIYCPPKVQGALDLQSGILHAADERDFKTAFSYFYEAFEGFDSVDSVKALTSLKYMLLCK 275
            ||||||||||||:|..||:||||:|||:|:|:|||:|||||||||:||:||.||:||||||||||
Human   194 RTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCK 258

  Fly   276 IMLGQSDDVNQLVSGKLAITYSGRDIDAMKSVAEASHKRSLADFQAALKEYKKELAEDVIVQAHL 340
            |||...:||..|||||||:.|:||..:|:|.||:||..||||||:.||.:|:.||.:|.|:..||
Human   259 IMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTHL 323

  Fly   341 GTLYDTMLEQNLCRIIEPYSRVQVAHVAESIQLPMPQVEKKLSQMILDKKFSGILDQGEGVLIVF 405
            ..|||.:|||||.|:|||:||||:.|::..|:|....||:|||||||||||.|||||||||||:|
Human   324 AKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLIIF 388

  Fly   406 EETPVDKTYERVLETIQSMGKVVDTLYQKAKKLS 439
            :|.|||||||..|||||:|.||||:||.|||||:
Human   389 DEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn6	NP_725412.2	RPN6	18..438	CDD:227488	286/421 (68%)
Rpn6	NP_725412.2	PCI	302..406	CDD:279707	64/103 (62%)
PSMD11	NP_001257411.1	RPN6	17..421	CDD:227488	278/405 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147408
Domainoid	1	1.000	248	1.000	Domainoid score	I2148
eggNOG	1	0.900	-	-		E1_COG5159
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2108
Inparanoid	1	1.050	562	1.000	Inparanoid score	I1088
Isobase	1	0.950	-	0	Normalized mean entropy	S570
OMA	1	1.010	-	-		QHG53498
OrthoDB	1	1.010	-	-		D1052430at2759
OrthoFinder	1	1.000	-	-		FOG0003528
OrthoInspector	1	1.000	-	-		oto89440
orthoMCL	1	0.900	-	-		OOG6_101896
Panther	1	1.100	-	-	LDO	PTHR10678
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2408
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720