DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn6 and psmd11b

DIOPT Version :9

Sequence 1:	NP_725412.2	Gene:	Rpn6 / 36638	FlyBaseID:	FBgn0028689	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_955886.1	Gene:	psmd11b / 322265	ZFINID:	ZDB-GENE-030131-984	Length:	422	Species:	Danio rerio

Alignment Length:	424	Identity:	283/424 - (66%)
Similarity:	344/424 - (81%)	Gaps:	4/424 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 MAGATL--FERAQALSSVNREEQDSSLLNKLVRDQEGAENDEERIRIKEQGILQQGELYKQEGKA 80
            ||.|.:  |:|||:|.|.:| .....:.:.:|| ::..|:|||.:|:|||.||:.|.|..:.|:|
Zfish     1 MAAAAVVEFQRAQSLISTDR-NASIDIFHSIVR-RDVQEDDEEAVRVKEQSILELGSLLAKTGQA 63

  Fly    81 KELADLIKVTRPFLSSISKAKAAKLVRSLVDMFLDMDAGTGIEVQLCKDCIEWAKQEKRTFLRQS 145
            .||..|:|..||||.||||||||:|||||:|:||||:|.||.||:||.:||||||.||||||||:
Zfish    64 AELGGLLKFVRPFLISISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKAEKRTFLRQA 128

  Fly   146 LEARLIALYFDTALYTEALALGAQLLRELKKLDDKNLLVEVQLLESKTYHALSNLPKARAALTSA 210
            ||||||:|||||..|.|||.|.:|||:||||:|||.|||||||||||||||||||||||||||||
Zfish   129 LEARLISLYFDTKRYQEALQLESQLLQELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSA 193

  Fly   211 RTTANAIYCPPKVQGALDLQSGILHAADERDFKTAFSYFYEAFEGFDSVDSVKALTSLKYMLLCK 275
            ||||||||||||:|.|||:||||.|||:|:|:|||:|||:|||||:||:||.:|:|:||||||||
Zfish   194 RTTANAIYCPPKLQAALDMQSGITHAAEEKDWKTAYSYFFEAFEGYDSIDSPRAVTALKYMLLCK 258

  Fly   276 IMLGQSDDVNQLVSGKLAITYSGRDIDAMKSVAEASHKRSLADFQAALKEYKKELAEDVIVQAHL 340
            |||...::|..|:||||.:.|:||..||:|.:|:||..||||||:.||.||.|||.:|.|:..||
Zfish   259 IMLSLPEEVQALISGKLGLRYAGRQTDALKCIAQASKNRSLADFEKALTEYTKELRDDPIINTHL 323

  Fly   341 GTLYDTMLEQNLCRIIEPYSRVQVAHVAESIQLPMPQVEKKLSQMILDKKFSGILDQGEGVLIVF 405
            ..|||.:|||||.|:|||:||||:.|:|..|:|....||:|||||||||||.|||||||.|||:|
Zfish   324 AKLYDNLLEQNLIRVIEPFSRVQITHIAGLIKLSKNDVERKLSQMILDKKFHGILDQGEDVLIIF 388

  Fly   406 EETPVDKTYERVLETIQSMGKVVDTLYQKAKKLS 439
            ||.|||||||..|||||:|.||||:||.|||||:
Zfish   389 EEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn6	NP_725412.2	RPN6	18..438	CDD:227488	281/421 (67%)
Rpn6	NP_725412.2	PCI	302..406	CDD:279707	66/103 (64%)
psmd11b	NP_955886.1	RPN6	17..421	CDD:227488	273/405 (67%)
psmd11b	NP_955886.1	PCI	285..389	CDD:279707	66/103 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581235
Domainoid	1	1.000	245	1.000	Domainoid score	I2139
eggNOG	1	0.900	-	-		E1_COG5159
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2108
Inparanoid	1	1.050	559	1.000	Inparanoid score	I1066
OMA	1	1.010	-	-		QHG53498
OrthoDB	1	1.010	-	-		D1052430at2759
OrthoFinder	1	1.000	-	-		FOG0003528
OrthoInspector	1	1.000	-	-		otm24692
orthoMCL	1	0.900	-	-		OOG6_101896
Panther	1	1.100	-	-	LDO	PTHR10678
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1205
SonicParanoid	1	1.000	-	-		X2408
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800