DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jef and MFSD6

DIOPT Version :9

Sequence 1:	NP_001246323.1	Gene:	jef / 36634	FlyBaseID:	FBgn0033958	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	NP_001362915.1	Gene:	MFSD6 / 54842	HGNCID:	24711	Length:	791	Species:	Homo sapiens

Alignment Length:	694	Identity:	252/694 - (36%)
Similarity:	373/694 - (53%)	Gaps:	125/694 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 ELIPVKSFYFFFYAAFGSLFPLMGVYFKQMGMNPGQCGILVGMRPFVEFLSAPFWGSYADRCRQG 176
            :|:..|.||||||:|:|||:||:.||:||:||:|.|.|:|||:|.|:||.||||||..|||.::|
Human    67 DLLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKG 131

  Fly   177 KRLLLGSLACWVLFTIPLSFIRPEAINCIER-------RNA-------------TDFVLTYTRTK 221
            |.:||.||.|||||.:.:.|::|..:.|:.:       .||             |.| ||.:...
Human   132 KIVLLFSLLCWVLFNLGIGFVKPATLRCVPKIRPTTHPTNASHQLTILPTNSSFTSF-LTISPKM 195

  Fly   222 RDLSAMYEQEHLDMGTGTMP------ADEALEEAEAAHSRHKRSLLLPRIDAGISPVHINFVSNY 280
            |:...:.|.......|.|:|      ::..|:......:.....|.|....|  :||....|:
Human   196 REKRNLLETRLNVSDTVTLPTAPNMNSEPTLQPQTGEITNRMMDLTLNSSTA--TPVSPGSVT-- 256

  Fly   281 DDKYHRDYVTPIFSS----------MVYRTPDIQKAFFLLLLVILIGEFFSAPAITLADSAVITL 335
                 ::..|.|.::          :||...:::..|.::|:|::|||||||.::|:.|:..:..
Human   257 -----KETTTVIVTTTKSLPSDQVMLVYDQQEVEAIFLVILVVVIIGEFFSASSVTIVDTVTLQY 316

  Fly   336 LGEDADKYGHQRMFGSLGWGISMFLVGIALDHSTSFSNHPCGAGNKE---KNYNICFSIFSVLMT 397
            ||:..|:||.|||:||||||::|..|||.:|: |.......|.|.|.   :||.|.|.:|.||||
Human   317 LGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDY-THIEVLIDGKGCKPPEYRNYQIVFIVFGVLMT 380

  Fly   398 CAIISASKITFKYDPIDEQLAAQQQAQFVDPNKRAEEESMNQLAAQLNLPSLAVGSGSAASGACA 462
            .|:|.|::..|:|:            .|.:.:.:.:|         :.:|.:...:.:.:|
Human   381 MALIVATQFRFRYN------------HFKNDDSKGKE---------VEIPQVERNNSTESS---- 420

  Fly   463 GGVSSFLATGHQPQPHIGAESKVFAQTAKELPEWMTVLTHFKDL-------KTASFLFVAWFMGF 520
                       :..|...:.|:.|               :|.||       :..|.|||||||||
Human   421 -----------EETPTTTSHSQAF---------------NFWDLIKLLCSVQYGSVLFVAWFMGF 459

  Fly   521 GIGLIFTFLFWHLQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRF 585
            |.|.:||||:|||:|..||.|||||.||::||||:.|||||.:||..|||::||.:||..|..|:
Human   460 GYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARY 524

  Fly   586 LYISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIHHGLGRGCGAII 650
            :|||||.|.|.|||.|::||:||||:|||..||::...|..||.||||:|||:|.||||||||:|
Human   525 IYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMI 589

  Fly   651 GGMFVTYYGTTTTFRWYGIACLFVLGFFIFVNFY-----RKEQGFISE-IPVTEDPHQVA----- 704
            ||:.|.|:|...|||..|:|||.:|..|..:.:.     .:::..::| |||...|..:|
Human   590 GGVLVNYFGAAATFRGIGMACLVILLLFALIQWLAVPDEEEDKTMLAERIPVPSSPVPIATIDLV 654

  Fly   705 -EETSHLAPHGVPSNPIPRALSNSRLNEMNP-----NGGPYGTY 742
             ::|..:.|...|..|..:........::|.     :..|:.|:
Human   655 QQQTEDVMPRIEPRLPPKKTKHQEEQEDVNKPAWGVSSSPWVTF 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jef	NP_001246323.1	MFS	125..187	CDD:304372	37/61 (61%)
		MFS	508..>681	CDD:119392	105/172 (61%)
		MFS_1	511..>701	CDD:284993	108/195 (55%)
MFSD6	NP_001362915.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..47
		MFS_MFSD6	70..622	CDD:340893	238/613 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..427		3/34 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..687		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	723..791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157827
Domainoid	1	1.000	396	1.000	Domainoid score	I759
eggNOG	1	0.900	-	-		E1_KOG3762
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9784
Inparanoid	1	1.050	412	1.000	Inparanoid score	I1860
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47931
OrthoDB	1	1.010	-	-		D290600at33208
OrthoFinder	1	1.000	-	-		FOG0005424
OrthoInspector	1	1.000	-	-		oto90595
orthoMCL	1	0.900	-	-		OOG6_104266
Panther	1	1.100	-	-	LDO	PTHR16172
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4359
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770