Protein Alignment jef and MFSD6L

DIOPT Version :9

• Sequence 1: NP_001246323.1
• Gene: jef / 36634
• FlyBaseID: FBgn0033958
• Length: 762
• Species: Drosophila melanogaster
• Sequence 2: NP_689812.3
• Gene: MFSD6L / 162387
• HGNCID: 26656
• Length: 586
• Species: Homo sapiens
• Alignment Length: 659
• Identity: 135/659 - (20%)
• Similarity: 239/659 - (36%)
• Gaps: 159/659 - (24%)

  Fly   111 RELIPVKSFYFFFYAAFGSLFPLMGVYFKQMGMNPGQCGILVGMRPFVEFLSAPFWGSYADRCRQ 175
            |.|...|.|:.........:.|.:.:|.:|:|:.....|.|:|.:..:....||.....|...|:
Human    11 RALGVAKLFHLVCGVREACVTPFLTLYLRQLGLAAPWVGTLMGTKHLIAAFWAPVCAFLAKSYRK 75

  Fly   176 GKRLLLGSLACWVLFTIPLSFIRPEAINCI-------ERRNATDFV------LTYTRTKRDLSAM 227
            .:.||:|||...|..::.:..:.|...|.:       ....:||.:      :..|..:...|:.
Human    76 RRALLIGSLLGSVGASLLMVLVPPVDKNRVHFPCNGSSGLTSTDALPGVTLPVNITSAQESASSH 140

  Fly   228 YEQEHLDM---GTGTMPADEALEEAEAAH---------SRHKRSLLLPRIDAGIS--PVHINF-- 276
            ..:...::   |....|.:...|.....|         :|.....||..:.:|:.  |..:.|
Human   141 PAKRTAEVEMPGFRNPPGESDRETFRDLHVYLAPSVEGARTTSQALLHPVTSGLKDHPWEVTFEV 205

  Fly   277 ----------------VSNYDDKYHRDYVTPIFSSMVYRTPDIQKAFFLLLLVILIGEFFSAPAI 325
                            .:|......:.:...:....:.||      |.|.|..:...|..:||..
Human   206 VKTALPLLPGGKGPGNPANLSGTKGKAWAFDLSLEALRRT------FILSLGSVAFWELLTAPLE 264

  Fly   326 TLADSAVITLLG--EDADKYGHQRMFGSLGW-----GISMFLVGIALDHSTSFSNHPCGAGNKEK 383
            .:||.::...|.  :..|:|....::..||.     ||:. ||| .|| ....::.|.|.
Human   265 QVADDSLYEFLDFVDATDRYRSLWVWRLLGMSAGVCGITA-LVG-QLD-CFLMTSGPRGV----- 321

  Fly   384 NYNICFSIFSVLMTCAIISASKITFKYDPIDEQLAAQQQAQFVDPN-KRAEEESMNQLAAQLNLP 447
               :.|..:||:.|.|::.:  |.|.. ||.:|.         :|: ||.:..|:
Human   322 ---VHFYGYSVVSTLALLVS--IAFPI-PICQQW---------EPSYKRVKALSI---------- 361

  Fly   448 SLAVGSGSAASGACAGGVSSFLATGHQPQPHIGAESKVFAQTAKELPEWMTVLTHFKDLKTASFL 512
                          .||           .||:    .:.|.|        |||
Human   362 --------------VGG-----------DPHL----ILLAST--------TVL------------ 377

  Fly   513 FVAWFMGFGIGLIFTFLFWHLQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLG 577
                 :|..:..:..|||||::|:|....:.|.:..::.:.||..:.|...|:.::....::.||
Human   378 -----VGAIVSTVQNFLFWHMKDHGSGELVMGFSVALSLLGEILLHPFKATLLRKLSRTGLVGLG 437

  Fly   578 LIGNVLRFLYISYLTNPWMVLPFELMQGITHAAVW---AASCSYIAHNTPKHLRASAQGVLQGIH 639
            |.....:.||.|:|.:.|.|||.:::..|::.|:|   .||...:|  ||:..|| ...:.:|..
Human   438 LSCLAGQLLYYSFLWSWWSVLPIQILSAISNRALWWAVGASVEDLA--TPRMERA-LSALFRGHF 499

  Fly   640 HGLGRGCGAIIGGMFVTYYGTTTTFRWYGIACLFVLGFFIFVNFYRKEQGFIS-------EIPVT 697
            :|.|...|:.:||..|..:.....::...:|.|..|...:.:......:..|.       |:..|
Human   500 YGSGCSLGSFVGGFVVMRFSLAVLYQACCVALLLWLALLLSIQRRLPRERKIKYSKLLSMEVSDT 564

  Fly   698 EDPHQVAEE 706
            .|..|..|:
Human   565 SDSEQGTEQ 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jef	NP_001246323.1	MFS	125..187	CDD:304372	16/61 (26%)
		MFS	508..>681	CDD:119392	44/175 (25%)
		MFS_1	511..>701	CDD:284993	48/199 (24%)
MFSD6L	NP_689812.3	MFS	<28..87	CDD:304372	16/58 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	133..160		3/26 (12%)
		MFS	368..>529	CDD:119392	46/192 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3762
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810