DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jef and AgaP_AGAP003204

DIOPT Version :9

Sequence 1:	NP_001246323.1	Gene:	jef / 36634	FlyBaseID:	FBgn0033958	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	XP_312908.4	Gene:	AgaP_AGAP003204 / 1273877	VectorBaseID:	AGAP003204	Length:	722	Species:	Anopheles gambiae

Alignment Length:	749	Identity:	493/749 - (65%)
Similarity:	581/749 - (77%)	Gaps:	50/749 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PFGAPAGGAGYGQQGYGYEQQATGGYDQGMNYGIEPQQQAAGYGPPGARPRVDVEATGEVDPNLY 84
            ||....|| ||| .|.|||:|             :|||:........|||.||.||.|||||.||
Mosquito     3 PFSNDYGG-GYG-GGNGYEEQ-------------QPQQEIPMRTQGVARPMVDPEAMGEVDPTLY 52

  Fly    85 PEAKDSTHKVRGHSDILEMFFGASTERELIPVKSFYFFFYAAFGSLFPLMGVYFKQMGMNPGQCG 149
            |:||:||||:||.||||||.|| |.::||:|||:||||||:||||||||||||||||||||||||
Mosquito    53 PQAKESTHKIRGKSDILEMLFG-SVDQELLPVKTFYFFFYSAFGSLFPLMGVYFKQMGMNPGQCG 116

  Fly   150 ILVGMRPFVEFLSAPFWGSYADRCRQGKRLLLGSLACWVLFTIPLSFIRPEAINCIERRNATDFV 214
            :|:|.|||||||||||||||||||::||.|||.|||.|::||:||.||:|.|.:||||:|||||.
Mosquito   117 LLIGTRPFVEFLSAPFWGSYADRCKKGKMLLLASLAAWIIFTLPLGFIQPPATSCIERKNATDFE 181

  Fly   215 LTYTRTKRDLSAMYEQ---EHLDMGTGTMPADEALEEAEAAHSRHKRSLLLPRIDAGISPVHINF 276
            |...:..|.|....::   |.|..|.....:..:....|.|        ..|...||:||:.:::
Mosquito   182 LRTPQVPRILKRSIDESMLEELSFGKYATDSGSSFTRVERA--------ARPVAAAGVSPLDVSY 238

  Fly   277 VSNYDDKYHRDYVTPIFSSMVYRTPDIQKAFFLLLLVILIGEFFSAPAITLADSAVITLLGEDAD 341
            .:|:::|.|||:|:|:|||:||||.|||||||||||:::|||||||||||||||||||:||||||
Mosquito   239 ANNFNEKLHRDWVSPLFSSIVYRTADIQKAFFLLLLLVIIGEFFSAPAITLADSAVITILGEDAD 303

  Fly   342 KYGHQRMFGSLGWGISMFLVGIALDHSTSFSNHPCGAGNKEKNYNICFSIFSVLMTCAIISASKI 406
            :|||||||||||||::||.|||||||||:|.:||||...:||||.|||:.|||||..|:|||::|
Mosquito   304 RYGHQRMFGSLGWGLAMFFVGIALDHSTAFPDHPCGPEKQEKNYTICFATFSVLMGAALISATQI 368

  Fly   407 TFKYDPIDEQLAAQQQAQFVDPNKRAEEESMN-QLAAQLNLPSL-AVGSGSAASGACAGGVSSFL 469
            .||||..:.|...|.:..   |.:...||.|. |||.||.|||| |.|:|              :
Mosquito   369 QFKYDYSEPQEPVQVEKV---PQELTHEEQMQAQLAQQLQLPSLAATGTG--------------M 416

  Fly   470 ATGHQPQPHIGAESKVFAQTAKELPEWMTVLTHFKDLKTASFLFVAWFMGFGIGLIFTFLFWHLQ 534
            |:...|...:||::|:||||.:|:|||:|||..||:||.||||||||||||||||||||||||||
Mosquito   417 ASAAPPPAALGAQTKMFAQTTREMPEWVTVLKQFKNLKCASFLFVAWFMGFGIGLIFTFLFWHLQ 481

  Fly   535 DYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYISYLTNPWMVLP 599
            ||||:||||||||||||:||||||||||||||||||||||||||:||:|||||||||.|||.|||
Mosquito   482 DYGGSPTLFGVASVINHISEIFAYFFSFRLITQIGHVKVLCLGLVGNILRFLYISYLKNPWWVLP 546

  Fly   600 FELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIHHGLGRGCGAIIGGMFVTYYGTTTTF 664
            ||.||||||||||||.|||||||||:|||:||||||||:||||||||||:||||||||:|||.||
Mosquito   547 FEFMQGITHAAVWAACCSYIAHNTPQHLRSSAQGVLQGLHHGLGRGCGAVIGGMFVTYFGTTATF 611

  Fly   665 RWYGIACLFVLGFFIFVNFYRKEQGFISEIPVTEDPHQVAEETSHLAPHGVPSNPIPRALSNSRL 729
            |.||:.|:.||..|:|:|||||::|||||||.|||||||||||:|||||||||||||||||::||
Mosquito   612 RGYGVICILVLAAFVFINFYRKDEGFISEIPTTEDPHQVAEETAHLAPHGVPSNPIPRALSSTRL 676

  Fly   730 NEM---NPNGGPYGTYQTTGGNLDIPGANPHNPF 760
            ||:   |.:.| |||||||||.||:||..|.|||
Mosquito   677 NEIGQQNVDNG-YGTYQTTGGALDVPGGAPKNPF 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jef	NP_001246323.1	MFS	125..187	CDD:304372	53/61 (87%)
		MFS	508..>681	CDD:119392	149/172 (87%)
		MFS_1	511..>701	CDD:284993	163/189 (86%)
AgaP_AGAP003204	XP_312908.4	MFS_1_like	80..154	CDD:289593	63/73 (86%)
		MFS	455..>628	CDD:119392	149/172 (87%)
		MFS_1	458..>628	CDD:284993	147/169 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	761	1.000	Domainoid score	I357
eggNOG	1	0.900	-	-		E1_KOG3762
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9784
Inparanoid	1	1.050	980	1.000	Inparanoid score	I949
OMA	1	1.010	-	-		QHG47931
OrthoDB	1	1.010	-	-		D290600at33208
OrthoFinder	1	1.000	-	-		FOG0005424
OrthoInspector	1	1.000	-	-		oto109533
Panther	1	1.100	-	-	LDO	PTHR16172
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4359
TreeFam	1	0.960	-	-
	13	12.940