DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mspo and fat-spondin

DIOPT Version :9

Sequence 1:	NP_001286427.1	Gene:	mspo / 36632	FlyBaseID:	FBgn0020269	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_477435.1	Gene:	fat-spondin / 36919	FlyBaseID:	FBgn0026721	Length:	763	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	128/540 - (23%)
Similarity:	204/540 - (37%)	Gaps:	138/540 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 YYTDDPSPVSNLNPTASLATPPATQPAPQTGCTLDRLAVYKVVLHTYWTRELFPKHYPDWRPTAQ 147
            ::.||    .||: |......|....|.:..|..|. |.|..|....|:.|..||.||.......
  Fly   160 WFADD----GNLS-TVICERKPDAAAAQKECCACDE-AKYSFVFEGIWSNETHPKDYPFAIWLTH 218

  Fly   148 WTKTLGRTHNANYALYHIGQPATAAVKQFAESGRTDLLDSNAGEQQQVQMQLQSQMQAGKSPSGG 212
            ::..:|.:|.:|::.:.....|||..:..||.|....|::   |.:....:|::.::|.......
  Fly   219 FSDVIGASHESNFSFWGENHIATAGFRSLAEWGSPAALET---ELRANGPKLRTLIKAAGLWYPN 280

  Fly   213 ISSGTTSFNATAASTATPTGGSGGSGGSGGSGGTGTTTAERSVFDEFSMPAIPMGAGRSEAKVFV 277
            ::..|:|                                                      |..|
  Fly   281 VNQNTSS------------------------------------------------------KFRV 291

  Fly   278 DSNHSLVSLMTRIVPSPDWFIGVDSFELCVGG-SWIDTVTVELDPLDAGTDNGFTFTAPNWPTEP 341
            |..|..|||::...|||||.:|:...:||... ||.:::..:|.|.|||||:|.::.:||..|:|
  Fly   292 DRKHPKVSLVSMFGPSPDWVVGISGLDLCTEDCSWKESMDFDLFPWDAGTDSGISYMSPNSETQP 356

  Fly   342 QGVIYRITSRYPGHPAGSFYYPKSKRLPPIATFQFIKLKEYELSEVFNIAEDDRKYETVQTQTHL 406
            ...:||||:.||..|...||.|||:.:.|:|.....:.|      :.:...||...:.:|.:...
  Fly   357 PERMYRITTMYPEDPRAPFYNPKSREMTPLAKLYLRREK------IVSRNCDDEFLQALQLEVSD 415

  Fly   407 DAEHNHVEMN---------NELSASIERE-RQTEQQQLQQNDDERQRIRSQLLAKMNPIYGSNNS 461
            |||.......         :..|.|..:. |...:|.|.....::.:...||:||
  Fly   416 DAEEQDTRAECRVGDYSAWSPCSVSCGKGIRMRSRQYLYPAAADQNKCARQLVAK---------- 470

  Fly   462 LQPAPGQVVSVVPKNDKHAILQSIASSYRRAADASDANASKPTPSAIGGGKAGGAVGGGAATRRR 526
                 ...|:.:|:     .....|.|..|..|..:..|:  :.|.:|....|..:
  Fly   471 -----EMCVAAIPE-----CADGPAQSKDRDDDEGENLAN--SQSLVGSNGEGAGL--------- 514

  Fly   527 SSAQRRRDCRVSHWSEWTACSKSCGVGEMHRYRKVIKHGKRGGRQCP---ALQQSKW----CGTE 584
                    |:.|.||.|:.||.|||:|...|.|..:.|  .|.::||   .::::|.    |..|
  Fly   515 --------CKTSPWSVWSECSASCGIGITMRTRTFVNH--LGRKRCPHITIVEKNKCMRPDCTYE 569

  Fly   585 R------NCHGSQTYFNWSD 598
            :      .|..||    |||
  Fly   570 QVELPDPQCPTSQ----WSD 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mspo	NP_001286427.1	Spond_N	120..363	CDD:283999	62/243 (26%)
mspo	NP_001286427.1	TSP1	537..588	CDD:214559	19/63 (30%)
fat-spondin	NP_477435.1	Reeler	24..172	CDD:260081	5/16 (31%)
		Spond_N	191..378	CDD:283999	62/243 (26%)
		TSP1	428..473	CDD:214559	9/59 (15%)
		TSP1	518..566	CDD:214559	17/49 (35%)
		TSP1	581..627	CDD:214559	5/9 (56%)
		Kunitz_BPTI	643..694	CDD:278443
		TSP1	714..763	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3539
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11311
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920