DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mspo and Spon1

DIOPT Version :9

Sequence 1:	NP_001286427.1	Gene:	mspo / 36632	FlyBaseID:	FBgn0020269	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_663559.1	Gene:	Spon1 / 233744	MGIID:	2385287	Length:	807	Species:	Mus musculus

Alignment Length:	694	Identity:	155/694 - (22%)
Similarity:	240/694 - (34%)	Gaps:	215/694 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 FISNPSIYAYSVENQPDERESRDNNIKFAAEHGN----LNSNSNLNRNYYYTDDPSPVSNL---N 95
            |:||..:   :|......|.:|......|...|.    |.::....|..|:.|:.|....|   :
Mouse   124 FMSNCPV---AVTESTPRRRTRIQVFWIAPPTGTGCVILKASIVQKRIIYFQDEGSLTKKLCEQD 185

  Fly    96 PTASLATPPATQPAPQTGCTLDRLAVYKVVLHTYWTRELFPKHYPDWRPTAQWTKTLGRTHNANY 160
            ||....|     ..|...|.....|.|::..:..|:.:..||.||  |....|:..:|.:|:.||
Mouse   186 PTLDGVT-----DRPILDCCACGTAKYRLTFYGNWSEKTHPKDYP--RRANHWSAIIGGSHSKNY 243

  Fly   161 ALYHIGQPATAAVKQFAESGRTDLLDSNAGEQQQ---VQMQLQSQMQAGKSPSGGISSGTTSFNA 222
            .|:..|..|:..|||.||.|....::....:|..   ..::.::|..|.:           ..|.
Mouse   244 VLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQ-----------PVNV 297

  Fly   223 TAASTATPTGGSGGSGGSGGSGGTGTTTAERSVFDEFSMPAIPMGAGRSEAKVFVDSNHSLVSLM 287
            .||.:|                             |||                ||....|:|.:
Mouse   298 RAAPSA-----------------------------EFS----------------VDRTRHLMSFL 317

  Fly   288 TRIVPSPDWFIGVDSFELCVGG-SWIDTVTVELDPLDAGTDNGFTFTAPNWPTEPQGVIYRITSR 351
            |.:.|||||.:|:.:.:||... .|:..|..:|.|.|||||:|.|:.:||.||.||..|..:||.
Mouse   318 TMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTSL 382

  Fly   352 YPGHPAGSFYYPKSKRLPPIATFQFIKLKEYELSEVFNIAED-----------DRKYETVQTQTH 405
              .||...||.|:...:..:|.....::.  ...|..||..|           :.|.|....:|.
Mouse   383 --DHPQSPFYDPEGGSITQVARVVIERIA--RKGEQCNIVPDNVDDIVADLAPEEKDEDDTPETC 443

  Fly   406 LDAEHNHVEMNNELSASIERERQTEQQQLQQ----------------------NDDE-------- 440
            :.:  |....:...|::.|:.::..|:.|:.                      :|::
Mouse   444 IYS--NWSPWSACSSSTCEKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSE 506

  Fly   441 ---------------RQRIRSQLLAKMNPIYGS--------------NNSLQPAPGQVVSVVPKN 476
                           |.|.|   ..|..|..||              |....|:...|......:
Mouse   507 WITWSPCSVSCGMGMRSRER---YVKQFPEDGSVCMLPTEETEKCTVNEECSPSSCLVTEWGEWD 568

  Fly   477 D-----------KHAILQ-SIASSYRRAADASDANA----------------SKPTPSAIGGGKA 513
            |           :|.::: |.|......|:.|.|..                |:.:..::..||
Mouse   569 DCSATCGMGMKKRHRMVKMSPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGK- 632

  Fly   514 GGAVGGGAATRRR---------------SSAQRRR------DCRVSHWSEWTACSKSCGVGEMHR 557
                  |..||:|               ..|::..      ||.:|.||:|:.|:||||.|.|.|
Mouse   633 ------GMRTRQRMLKSLAELGDCNEDLEQAEKCMLPECPIDCELSEWSQWSECNKSCGKGHMIR 691

  Fly   558 YRKVIKHGKRGGRQCPALQQSKWCGTERNCHGSQTY--FNWSDS 599
            .|.:....:.||..||...|.|.|.| |.|..|.:.  ..|.::
Mouse   692 TRTIQMEPQFGGVPCPETVQRKKCRT-RKCLRSPSVQKLRWREA 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mspo	NP_001286427.1	Spond_N	120..363	CDD:283999	69/246 (28%)
mspo	NP_001286427.1	TSP1	537..588	CDD:214559	22/50 (44%)
Spon1	NP_663559.1	Reeler	43..182	CDD:260081	13/60 (22%)
		Spond_N	205..392	CDD:283999	69/246 (28%)
		TSP_1	446..494	CDD:278517	5/49 (10%)
		TSP_1	505..554	CDD:278517	8/51 (16%)
		TSP_1	562..610	CDD:278517	7/47 (15%)
		TSP_1	618..665	CDD:278517	8/53 (15%)
		TSP_1	672..720	CDD:278517	22/48 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..752		0/3 (0%)
		TSP_1	758..807	CDD:278517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3539
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3762
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850